The role of cadherin genes in five major psychiatric disorders: A literature update
| العنوان: | The role of cadherin genes in five major psychiatric disorders: A literature update |
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| المؤلفون: | Hannah Yates, Ziarih Hawi, Mark A. Bellgrove, Janette Tong, Beth Patricia Johnson, Callum Dark |
| المصدر: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 177:168-180 |
| بيانات النشر: | Wiley, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Candidate gene, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine, Humans, Genetic Predisposition to Disease, Psychiatry, Genetics (clinical), Genetics, Cadherin, Mental Disorders, Genomics, Cadherins, medicine.disease, 3. Good health, Psychiatry and Mental health, 030104 developmental biology, Autism spectrum disorder, Schizophrenia, Major depressive disorder, Literature survey, 030217 neurology & neurosurgery, Genome-Wide Association Study, Adherens junction organization |
| الوصف: | Converging evidence from candidate gene, genome-wide linkage, and association studies support a role of cadherins in the pathophysiology of five major psychiatric disorders including attention deficit hyperactivity disorder, autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). These molecules are transmembrane proteins which act as cell adhesives by forming adherens junctions (AJs) to bind cells within tissues. Members of the cadherin superfamily are also involved in biological processes such as signal transduction and plasticity that have been implicated in the etiology of major psychiatric conditions. Although there are over 110 genes mapped to the cadherin superfamily, our literature survey showed that evidence of association with psychiatric disorders is strongest for CDH7, CHD11, and CDH13. Gene enrichment analysis showed that those cadherin genes implicated in psychiatric disorders were overrepresented in biological processes such as in cell-cell adhesion (GO:0007156 & GO:0098742) and adherens junction organization (GO:0034332). Further, cadherin genes were also mapped to processes that have been linked to the development of psychiatric disorders such as nervous system development (GO:0007399). To further understand the role of cadherin SNPs implicated in psychiatric disorders, we utilized an in silico computational pipeline to functionally annotate associated variants. This analysis yielded eight variants mapped to PCDH1-13, CDH7, CDH11, and CDH13 that are predicted to be biologically functional. Functional genomic evaluation is now required to understand the molecular mechanism by which these variants might confer susceptibility to psychiatric disorders. |
| تدمد: | 1552-485X 1552-4841 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cb1f7f8ffb3d9c0097723665d76667Test https://doi.org/10.1002/ajmg.b.32592Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....15cb1f7f8ffb3d9c0097723665d76667 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1552485X 15524841 |
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