The structures of xenorine A–C from the entomopathogenic bacterium Xenorhabdus indica
| العنوان: | The structures of xenorine A–C from the entomopathogenic bacterium Xenorhabdus indica |
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| المؤلفون: | Lie-Feng Ma, You-Min Ying, Jian-Biao Yao, Zha-Jun Zhan, Wei-Guang Shan, Wei-Wei Pang, Ling Fang, Yuan-Yuan Li, Hao-Ying Qian, Yang Zheng |
| المصدر: | Journal of Chemical Research. 41:262-265 |
| بيانات النشر: | SAGE Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Xenorhabdus indica, Natural product, biology, 010405 organic chemistry, Stereochemistry, Absolute configuration, General Chemistry, medicine.disease_cause, biology.organism_classification, 01 natural sciences, In vitro, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Product (mathematics), medicine, Density functional theory, Two-dimensional nuclear magnetic resonance spectroscopy, Bacteria |
| الوصف: | Three new compounds, xenorine A-C, along with six known compounds were isolated from the cultured broth of Xenorhabdus indica. The chemical structures of these compounds were elucidated mainly by analysis of 1D and 2D NMR and MS data. The major metabolites were dioxopiperazines. In addition, 5,6,11,11a-tetrahydro-1 H-imidazo[1′,5′:1,6]pyrido[3,4- b]indole-1,3(2 H)-dione, previously described as synthetic product, was isolated as a natural product. The absolute configuration was determined using quantum chemical time-dependent density functional theory calculations. The six known compounds showed weak in vitro immunosuppressive activity towards concanavalin-A- and lipopolysaccharide -induced proliferation of mice splenocytes. |
| تدمد: | 2047-6507 1747-5198 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a874055eda852162f3de5865c7be24b1Test https://doi.org/10.3184/174751917x14925986241016Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........a874055eda852162f3de5865c7be24b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20476507 17475198 |
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