Effects of prunus cerasus L. Seeds and juice on liver steatosis in an animal model of diet-induced obesity
| العنوان: | Effects of prunus cerasus L. Seeds and juice on liver steatosis in an animal model of diet-induced obesity |
|---|---|
| المؤلفون: | Consuelo Amantini, Maria Vittoria Micioni Di Bonaventura, Francesco Amenta, Carlotta Marini, Michele Moruzzi, Alessandro Fruganti, Carlo Polidori, Seyed Khosrow Tayebati, Andrea Marchegiani, Giulio Lupidi, Federica Maggi, Maria Gabriella Gabrielli, Daniele Tomassoni, Ilenia Martinelli, Carlo Cifani, Fabrizio Dini |
| المصدر: | Nutrients, Vol 12, Iss 1308, p 1308 (2020) Nutrients Volume 12 Issue 5 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, obesity, medicine.medical_specialty, medicine.medical_treatment, diet-induced obese rats, Adipose tissue, lcsh:TX341-641, liver, tart cherry, 03 medical and health sciences, Internal medicine, medicine, ddc:610, anthocyanins, 030109 nutrition & dietetics, Nutrition and Dietetics, biology, Chemistry, Insulin, Endoplasmic reticulum, medicine.disease, biology.organism_classification, Obesity, Prunus cerasus, 030104 developmental biology, Endocrinology, Blood pressure, Unfolded protein response, Steatosis, lcsh:Nutrition. Foods and food supply, hormones, hormone substitutes, and hormone antagonists, Food Science |
| الوصف: | The accumulation of adipose tissue increases the risk of several diseases. The fruits-intake, containing phytochemicals, is inversely correlated with their development. This study evaluated the effects of anthocyanin-rich tart cherries in diet-induced obese (DIO) rats. DIO rats were exposed to a high-fat diet with the supplementation of tart cherry seeds powder (DS) and seed powder plus juice (DJS). After 17 weeks, the DIO rats showed an increase of body weight, glycaemia, insulin, and systolic blood pressure. In the DS and DJS groups, there was a decrease of systolic blood pressure, glycaemia, triglycerides, and thiobarbituric reactive substances in the serum. In the DJS rats, computed tomography revealed a decrease in the spleen-to-liver attenuation ratio. Indeed, sections of the DIO rats presented hepatic injury characterized by steatosis, which was lower in the supplemented groups. In the liver of the DIO compared with rats fed with a standard diet (CHOW), a down-regulation of the GRP94 protein expression and a reduction of LC3- II/LC3-I ratio were found, indicating endoplasmic reticulum stress and impaired autophagy flux. Interestingly, tart cherry supplementation enhanced both unfolded protein response (UPR) and autophagy. This study suggests that tart cherry supplementation, although it did not reduce body weight in the DIO rats, prevented its related risk factors and liver steatosis. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bbff27e1562981d452701aef002f7eTest http://hdl.handle.net/11573/1496947Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b8bbff27e1562981d452701aef002f7e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |