نتائج البحث

1

Safety, Pharmacokinetics, and Pharmacodynamics of the Oral TLR8 Agonist Selgantolimod in Chronic Hepatitis B

المؤلفون: Circe McDonald, Jeffrey J. Wallin, Anh Hoa Nguyen, Diana Y. Chen, Edward Gane, Priyanka Arora, Kumar Visvanathan, Hyung Joon Kim, Young-Suk Lim, Susanna K. Tan, Anuj Gaggar, Yoon Jun Kim, Stuart K. Roberts

المصدر: Hepatology. 74:1737-1749

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Agonist, medicine.medical_specialty, Sustained Virologic Response, Nausea, medicine.drug_class, medicine.disease_cause, Placebo, Antiviral Agents, Dizziness, Gastroenterology, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Clinical endpoint, Humans, Adverse effect, Hepatitis B virus, Dose-Response Relationship, Drug, Hepatology, Interleukin-12 Subunit p40, business.industry, Headache, Middle Aged, Interleukin 1 Receptor Antagonist Protein, Pyrimidines, 030104 developmental biology, Toll-Like Receptor 8, Pharmacodynamics, Female, 030211 gastroenterology & hepatology, medicine.symptom, Hexanols, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eaee717e84933eb95f6de3ac41a3f49Test
https://doi.org/10.1002/hep.31795Test

2

Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China

المؤلفون: Ying Huang, Jiabin Chen, Xiaowen Jiang, Yaling Shi, Jide Huang, Yingyi Huang, Xing Chen

المصدر: Human Immunology

مصطلحات موضوعية: Male, 0301 basic medicine, G-CSF, Granulocyte colony-stimulating factor, Severity of Illness Index, T-Lymphocytes, Regulatory, Gastroenterology, MCP-1, Monocyte chemoattractant protein-1, 0302 clinical medicine, Immunology and Allergy, IL, Interleukin, IL-2 receptor, B-Lymphocytes, COVID-19, Coronavirus disease 2019, biology, Th1, T helper 1, Immune cells, EDTA, Ethylenediaminetetraacetic acid, General Medicine, Middle Aged, Prognosis, PBS, Phosphate-buffered saline, WBC, White blood cells, Interleukin-10, Up-Regulation, IFN, Interferon, Th2, T helper 2, Killer Cells, Natural, Interleukin 10, Cytokines, Female, medicine.symptom, Research Article, Adult, China, medicine.medical_specialty, MIP-1A, Macrophage inflammatory protein 1 alpha, Immunology, NKT cells, Natural killer T cells, Inflammation, Tregs, Regulatory T cells, macromolecular substances, 03 medical and health sciences, Immune system, Internal medicine, Severity of illness, medicine, Humans, Lymphocyte Count, Interleukin-7 receptor, Interleukin 6, Aged, Interleukin-6, SARS-CoV-2, business.industry, IP-10, Interferon gamma-induced protein 10, TNF, Tumor necrosis factor, COVID-19, NK cells, Natural killer cells, 030104 developmental biology, biology.protein, business, CD8, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a70e9df0e9f88464b7539e60bc6d2cTest
https://doi.org/10.1016/j.humimm.2020.08.006Test

3

Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans

المؤلفون: Chin Wong, Thomas Gelzleichter, Junichiro Sonoda, Amos Baruch, Linda Morrow, Suresh Dheerendra, Leslie W. Chinn, Richard Boismenu, Eric Wakshull, Maria E. Wilson, Puneet S. Arora, Shan Chen, Anjali Vaze, Johnny Gutierrez, Nicholas Lewin-Koh

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Male, 0301 basic medicine, obesity, Medical Sciences, FGF21, Adipose tissue, Mice, 0302 clinical medicine, Weight loss, Homeostasis, Medicine, Multidisciplinary, biology, Middle Aged, Biological Sciences, Adipose Tissue, Female, Adiponectin, Antibody, medicine.symptom, FGF21 receptor activation, Adult, Agonist, medicine.medical_specialty, Adolescent, medicine.drug_class, 030209 endocrinology & metabolism, Antibodies, Food Preferences, Young Adult, 03 medical and health sciences, Internal medicine, Weight Loss, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 1, Aged, business.industry, Fibroblast growth factor receptor 1, Body Weight, medicine.disease, Obesity, Fibroblast Growth Factors, stomatognathic diseases, Macaca fascicularis, 030104 developmental biology, Endocrinology, biology.protein, food preference, business, metabolism, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1e6fc5999a3fd66bc3ad16e368b18Test
https://doi.org/10.1073/pnas.2012073117Test

4

Structural Alterations in Deep Brain Structures in Type 1 Diabetes

المؤلفون: Antonietta Canna, Pavel Filip, Elizabeth R. Seaquist, Amir Moheet, Petr Bednarik, Xiufeng Li, Anjali Kumar, Evan Olawsky, Lynn E. Eberly, Heidi Gröhn, Silvia Mangia

المصدر: Diabetes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1ae40dea36315feffa31a00a6b7b5fTest
https://doi.org/10.2337/db19-1100Test

5

Ryanodine Receptor 1-Related Myopathies: Quantification of Intramuscular Fatty Infiltration from T1-Weighted MRI

المؤلفون: Christopher Grunseich, M. Waite, Joshua J. Todd, Aneesh Patankar, Jessica W Witherspoon, Katherine G. Meilleur, Irene C Chrismer, Xuemin Zhang, Muslima S Razaqyar, Tokunbor A. Lawal, Minal Jain, Magalie Emile-Backer, Chia-Ying Liu

المصدر: Journal of Neuromuscular Diseases

مصطلحات موضوعية: Adult, Male, Research Report, 0301 basic medicine, medicine.medical_specialty, Adolescent, Ryanodine receptor 1, Muscle disorder, muscle disorders, muscle disease manifestations, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Muscular Diseases, Internal medicine, T1 weighted, Humans, computer-assisted image analysis, Medicine, skeletal muscle, Child, Muscle, Skeletal, Myopathy, Leg, medicine.diagnostic_test, business.industry, Ryanodine receptor, Significant difference, Ryanodine Receptor Calcium Release Channel, Magnetic resonance imaging, Middle Aged, Magnetic Resonance Imaging, central core myopathy, 030104 developmental biology, Neurology, Ambulatory, Cardiology, Female, Neurology (clinical), Fatty infiltration, medicine.symptom, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d4f37ce32baafb3c372f647ecc21e3Test
https://doi.org/10.3233/jnd-200549Test

6

Safety, pharmacokinetics, and preliminary efficacy of the PARP inhibitor talazoparib in Japanese patients with advanced solid tumors: phase 1 study

المؤلفون: Yasutoshi Kuboki, Yuko Mori, Yoichi Naito, Takahiro Kogawa, Nobuaki Matsubara, Shigeyuki Toyoizumi, Takashi Nagasawa, Kenichi Harano, Masafumi Ikeda, Natsuki Hori

المصدر: Investigational New Drugs

مصطلحات موضوعية: Adult, 0301 basic medicine, medicine.medical_specialty, Maximum Tolerated Dose, Anemia, Talazoparib, Cmax, Antineoplastic Agents, Phase 1, Poly(ADP-ribose) Polymerase Inhibitors, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Asian People, Japan, Pharmacokinetics, Phase I Studies, Neoplasms, Internal medicine, medicine, Maculopapular rash, Clinical endpoint, Humans, Pharmacology (medical), Neoplasm Metastasis, Adverse effect, Stomatitis, Aged, Pharmacology, Dose-Response Relationship, Drug, business.industry, Middle Aged, medicine.disease, PARP inhibitor, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Phthalazines, Safety, Neoplasm Grading, medicine.symptom, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ed123337d8369dfb1f4c651d0abc67Test
https://doi.org/10.1007/s10637-021-01120-7Test

7

Heparin cofactor II reduces albuminuria

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2172-2182 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Urine, 030204 cardiovascular system & hematology, 0302 clinical medicine, Diabetic Nephropathies, Heparin cofactor II, Confounding, Thrombin, Articles, General Medicine, Middle Aged, Clinical Science and Care, Creatinine, Regression Analysis, Original Article, Female, medicine.symptom, medicine.drug, Adult, medicine.medical_specialty, Receptors, Proteinase-Activated, Inflammation, Fatty Acid-Binding Proteins, Protease‐Activated Receptors, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Albumins, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Albuminuria, Aged, business.industry, Albumin, RC648-665, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Protease-Activated Receptors, business, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49f18135c3ed880879b918fba3ed84fTest
https://doi.org/10.1111/jdi.13602Test

8

Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients

المؤلفون: Weiyang Zhong, Rui Chen, Xiaoji Luo, Xinjie Liang, Tianji Huang

المصدر: Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-7 (2020)
Journal of Orthopaedic Surgery and Research

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, Time Factors, lcsh:Diseases of the musculoskeletal system, Intervertebral Disc Degeneration, Gastroenterology, Body Mass Index, 0302 clinical medicine, lcsh:Orthopedic surgery, Risk Factors, Orthopedics and Sports Medicine, Child, Aged, 80 and over, Lumbar Vertebrae, Incidence (epidemiology), Venous blood, Middle Aged, Low back pain, Type 1 diabetes, Female, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Adolescent, 03 medical and health sciences, Young Adult, Sex Factors, Lumbar disc degeneration, Internal medicine, medicine, Humans, Risk factor, Aged, Retrospective Studies, Glycated Hemoglobin, business.industry, Retrospective cohort study, medicine.disease, lcsh:RD701-811, 030104 developmental biology, Diabetes Mellitus, Type 1, Orthopedic surgery, Surgery, lcsh:RC925-935, business, Body mass index, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9696b2335750df3eab4d38ba1c954021Test
http://link.springer.com/article/10.1186/s13018-020-01784-6Test

9

The Hypoxic Response Expression as a Survival Biomarkers in Treatment-Naive Advanced Breast Cancer

المؤلفون: Andi Fachruddin Benyamin, Andi Asadul Islam, Irwan Gunawan, Mochammad Hatta

المصدر: Asian Pacific Journal of Cancer Prevention : APJCP

مصطلحات موضوعية: Adult, 0301 basic medicine, Oncology, medicine.medical_specialty, Population, Breast Neoplasms, survival, carbonic anhydrase IX, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, Humans, Medicine, RNA, Messenger, Hypoxia, education, Aged, tumor hypoxia, Aged, 80 and over, Univariate analysis, education.field_of_study, Tumor hypoxia, business.industry, Proportional hazards model, Hazard ratio, General Medicine, Middle Aged, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Survival Analysis, Metastatic breast cancer, hypoxia-Inducible Factor 1, 030104 developmental biology, HIF1A, 030220 oncology & carcinogenesis, medicine.symptom, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa18e787dcfe51ca86780512b62d4a6Test
https://doi.org/10.31557/apjcp.2020.21.3.629Test

10

A novel GPR143 mutation in a Chinese family with X-linked ocular albinism type 1

المؤلفون: Wei Liu, Xuhui Gao, Tie-cheng Liu, Maonian Zhang, Xuan Cheng, Runpu Li, Aiai Dai

المصدر: Molecular Medicine Reports

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Cancer Research, medicine.medical_specialty, China, Visual acuity, ocular albinism type 1, genetic structures, Adolescent, Fundus (eye), Biochemistry, 03 medical and health sciences, Exon, 0302 clinical medicine, Asian People, Ophthalmology, G protein-coupled receptor 143 gene, Genetics, Medicine, Humans, Family, X-linked recessive inheritance, Eye Proteins, Molecular Biology, Aged, Membrane Glycoproteins, business.industry, Articles, Middle Aged, medicine.disease, Albinism, Ocular, eye diseases, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Decreased Visual Acuity, Mutation (genetic algorithm), Mutation, Albinism, Molecular Medicine, Ocular albinism type 1, Female, sense organs, medicine.symptom, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092c7cb281e8c69d6ce8e73d895645feTest
http://europepmc.org/articles/PMC6896309Test

تنقيح النتائج