نتائج البحث

1

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

المصدر: Nat Immunol

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Galectin 1, Lipopolysaccharide, Mice, chemistry.chemical_compound, 0302 clinical medicine, Alarmins, Immunology and Allergy, Caspase, Aged, 80 and over, Mice, Knockout, biology, Intracellular Signaling Peptides and Proteins, Pyroptosis, Middle Aged, Up-Regulation, Cell biology, Necroptosis, Female, Inflammation Mediators, medicine.symptom, Signal transduction, Intracellular, Signal Transduction, Adult, animal structures, Immunology, Inflammation, PTPRC, Article, 03 medical and health sciences, Sepsis, otorhinolaryngologic diseases, medicine, Animals, Humans, Aged, Macrophages, Phosphate-Binding Proteins, Endotoxemia, Mice, Inbred C57BL, Disease Models, Animal, stomatognathic diseases, RAW 264.7 Cells, 030104 developmental biology, chemistry, Case-Control Studies, biology.protein, Leukocyte Common Antigens, HeLa Cells, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd368de112bdf46f79b07a7aa7e0a0dTest
https://doi.org/10.1038/s41590-020-00844-7Test

2

YB-1 Is Altered in Pregnancy-Associated Disorders and Affects Trophoblast in Vitro Properties via Alternation of Multiple Molecular Traits

المؤلفون: Florence Fischer, Peter R. Mertens, Katja Woidacki, Violeta Stojanovska, Mario Bauer, Ana Claudia Zenclussen, Jonathan A. Lindquist, Aneri Shah

المصدر: International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 7226, p 7226 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, NF-κB, chemistry.chemical_compound, 0302 clinical medicine, Pre-Eclampsia, Cell Movement, Pregnancy, Biology (General), Spectroscopy, reproductive and urinary physiology, Gene knockdown, Fetal Growth Retardation, cold shock protein, NF-kappa B, apoptosis, General Medicine, Computer Science Applications, Cell biology, Trophoblasts, Up-Regulation, Chemistry, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, embryonic structures, Female, medicine.symptom, Adult, intrauterine growth restriction, QH301-705.5, placentation, Down-Regulation, Inflammation, Biology, In Vitro Techniques, Catalysis, Article, Cell Line, Inorganic Chemistry, preeclampsia, 03 medical and health sciences, Young Adult, Downregulation and upregulation, medicine, Humans, Secretion, RNA, Messenger, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Cell Proliferation, Organic Chemistry, Trophoblast, Placentation, Abortion, Spontaneous, Pregnancy Complications, 030104 developmental biology, chemistry, Case-Control Studies, Cancer cell, Y-Box-Binding Protein 1

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06de04b8ef3a0fd01de6d9d7d195c235Test
http://europepmc.org/articles/PMC8269420Test

3

Mitochondrial N-formyl methionine peptides associate with disease activity as well as contribute to neutrophil activation in patients with rheumatoid arthritis

المؤلفون: M. Kristen Demoruelle, J. Lee Nelson, Kevin D. Deane, Al Anoud Baddour, Christian Lood, Marie L. Feser, Bhargavi Duvvuri

المصدر: J Autoimmun

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, Neutrophils, Immunology, Inflammation, Enzyme-Linked Immunosorbent Assay, Mitochondrion, Severity of Illness Index, Formyl peptide receptor 1, Neutrophil Activation, Article, Arthritis, Rheumatoid, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Organelle, medicine, Immunology and Allergy, Humans, Clinical significance, In patient, Aged, 030203 arthritis & rheumatology, Methionine, business.industry, Middle Aged, medicine.disease, Prognosis, Mitochondria, 030104 developmental biology, chemistry, Rheumatoid arthritis, Case-Control Studies, Disease Progression, Female, Disease Susceptibility, medicine.symptom, business, Peptides, Reactive Oxygen Species, Transcriptome, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1e6151f87847ae0cfee8d255b60fe9Test
https://pubmed.ncbi.nlm.nih.gov/33713887Test

4

FOXP3, RORγt and IL-10 cytokine profile in chronic heart failure

المؤلفون: Zahra Rahmati, S. Sadati, A. A. Amirzargar, F Najmi Varzaneh, Nima Rezaei, Zahra Rahnemoon, Mehdi Mahmoudi, Vajiheh Eskandari, Fatemeh Gorzin, Mona Hedayat

المصدر: Bratislava Medical Journal. 118:637-641

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Economics and Econometrics, Retinoic acid, Inflammation, T-Lymphocytes, Regulatory, Peripheral blood mononuclear cell, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, RAR-related orphan receptor gamma, Materials Chemistry, Media Technology, medicine, Humans, RNA, Messenger, 030212 general & internal medicine, Aged, Heart Failure, business.industry, FOXP3, Forkhead Transcription Factors, Forestry, Middle Aged, Nuclear Receptor Subfamily 1, Group F, Member 3, medicine.disease, Pathophysiology, Interleukin-10, Interleukin 10, 030104 developmental biology, chemistry, Case-Control Studies, Heart failure, Chronic Disease, Immunology, Leukocytes, Mononuclear, Th17 Cells, Female, medicine.symptom, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59aca77bdff4889abbcca9109d41a3ddTest
https://doi.org/10.4149/bll_2017_122Test

5

SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

المؤلفون: Ying Liu, Guoqing Li, Fanru Meng, Yuxuan Fang, Zhongbing Xia, Chunwang Zhang, Dan Liu, Xia Wu

المصدر: Bioscience Reports

مصطلحات موضوعية: rheumatoid arthritis, Male, 0301 basic medicine, Fibroblast-like synoviocyte, Interleukin-1beta, Apoptosis, sirtuin 1, Biochemistry, NF-κB, Arthritis, Rheumatoid, Pathogenesis, chemistry.chemical_compound, Cell Movement, skin and connective tissue diseases, Research Articles, Caspase 8, biology, Caspase 3, Cell Cycle, Synovial Membrane, Middle Aged, musculoskeletal system, Synoviocytes, Rheumatoid arthritis, Female, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Research Article, Signal Transduction, Adult, musculoskeletal diseases, Primary Cell Culture, Biophysics, Inflammation, 03 medical and health sciences, medicine, Humans, Arthroplasty, Replacement, fibroblast-like synoviocytes, Molecular Biology, Aged, Cell Proliferation, Autoimmune disease, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Sirtuin 1, Interleukin-8, Transcription Factor RelA, Cell Biology, medicine.disease, enzymes and coenzymes (carbohydrates), 030104 developmental biology, Gene Expression Regulation, chemistry, inflammation, Case-Control Studies, Cancer research, biology.protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cf91acfb3ba53d0af6a323b9aab0b4Test
https://doi.org/10.1042/bsr20180541Test

6

Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency

المؤلفون: Børre Fevang, Bente Halvorsen, Xiang Yi Kong, Kari Otterdal, Azita Rashidi, Arne Yndestad, Magnhild Eide Macpherson, Pål Aukrust, Ida Gregersen, Rolf K. Berge, Kirsten B. Holven, Silje F. Jørgensen, Tom Eirik Mollnes, Thor Ueland

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
9:9427

مصطلحات موضوعية: Male, 0301 basic medicine, lcsh:Medicine, Systemic inflammation, medicine.disease_cause, Autoimmunity, chemistry.chemical_compound, 0302 clinical medicine, Medicine, lcsh:Science, Aged, 80 and over, Multidisciplinary, biology, Molecular medicine, Reverse cholesterol transport, Middle Aged, VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710, C-Reactive Protein, Female, Tumor necrosis factor alpha, lipids (amino acids, peptides, and proteins), Primary immunodeficiency disorders, medicine.symptom, ATP Binding Cassette Transporter 1, Adult, Adolescent, Down-Regulation, Article, Autoimmune Diseases, Young Adult, 03 medical and health sciences, Humans, Dyslipidaemias, Aged, Inflammation, Activating Transcription Factor 3, Apolipoprotein A-I, business.industry, Cholesterol, Macrophages, Common variable immunodeficiency, Cholesterol, HDL, lcsh:R, Interleukin-2 Receptor alpha Subunit, VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710, medicine.disease, Common Variable Immunodeficiency, 030104 developmental biology, chemistry, Case-Control Studies, ABCA1, Immunology, Leukocytes, Mononuclear, biology.protein, Primary immunodeficiency, lcsh:Q, business, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae62c4da525e2e958087c704bc69f79aTest
https://hdl.handle.net/1956/21257Test

7

Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome

المؤلفون: Antonio Moschetta, Natasha Scialpi, Massimiliano Copetti, Marilidia Piglionica, Giuseppe Di Tullio, Giusi Graziano, Michele Vacca, Marica Cariello, Giuseppe Palasciano, Simona D'Amore, Jennifer Härdfeldt, Carlo Sabbà

المساهمون: Vacca, Michele [0000-0002-1973-224X], Apollo - University of Cambridge Repository

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Physiology, Lipopolysaccharide Receptors, Down-Regulation, Inflammation, 03 medical and health sciences, chemistry.chemical_compound, Physiology (medical), Internal medicine, microRNA, medicine, ABCA1 Gene, Humans, 3' Untranslated Regions, Cells, Cultured, Metabolic Syndrome, Binding Sites, biology, Chemistry, Cholesterol, Three prime untranslated region, Reverse cholesterol transport, Cholesterol, HDL, nutritional and metabolic diseases, Biological Transport, Middle Aged, medicine.disease, MicroRNAs, 030104 developmental biology, Endocrinology, ABCA1, Case-Control Studies, biology.protein, Leukocytes, Mononuclear, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, Metabolic syndrome, Cardiology and Cardiovascular Medicine, Transcriptome, ATP Binding Cassette Transporter 1

وصف الملف: application/msword

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38878d037454f8a0c9eadab4cd05f41Test

8

Ectopic lipid accumulation: potential role in tubular injury and inflammation in diabetic kidney disease

المؤلفون: Jialu Liu, Wenxia Yang, Fuyou Liu, Shumin Zhang, Xuejing Zhu, Mengru Zeng, Yuzhang Han, Ying Luo, Shikun Yang, Li Xiao, Lin Sun, Yu Liu, Hao Wu

المصدر: Clinical science (London, England : 1979). 132(22)

مصطلحات موضوعية: 0301 basic medicine, Adult, Blood Glucose, Male, medicine.medical_specialty, Inflammation, Peripheral blood mononuclear cell, Perilipin-2, Cell Line, Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, Acetylglucosaminidase, medicine, Animals, Humans, Diabetic Nephropathies, Creatinine, Nephritis, Tumor Necrosis Factor-alpha, Lipid metabolism, General Medicine, Transfection, Lipid Droplets, Middle Aged, medicine.disease, Lipid Metabolism, Lipids, Sterol regulatory element-binding protein, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, Kidney Tubules, chemistry, Diabetes Mellitus, Type 2, Case-Control Studies, Leukocytes, Mononuclear, Tumor necrosis factor alpha, Female, medicine.symptom, Inflammation Mediators, Sterol Regulatory Element Binding Protein 1, Biomarkers, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9197d5efb0094220ce9e91c6c1ea37f4Test
https://pubmed.ncbi.nlm.nih.gov/30348828Test

9

Factors associated with increased irisin levels in the type 1 diabetes mellitus

المؤلفون: Mustafa Kaplan, Mehmet Fettah Arikan, K. Erdogan, Mahmut Yüksel, Ihsan Ates, Nisbet Yilmaz, Serdar Güler, Canan Topcuoglu

المساهمون: Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü

المصدر: Endocrine Regulations, Vol 51, Iss 1, Pp 1-7 (2017)

مصطلحات موضوعية: 0301 basic medicine, Male, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Insulin Antibodies, pgc1α, medicine.disease_cause, Autoimmunity, PGC1-α, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Glutamate Decarboxylase, Creatinine, Female, medicine.symptom, Adult, medicine.medical_specialty, HbA1c, 030209 endocrinology & metabolism, Inflammation, Enzyme-Linked Immunosorbent Assay, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Young Adult, ianti glutamic acid decarboxylase, Internal medicine, Diabetes mellitus, medicine, Humans, Risk factor, Autoantibodies, Glycated Hemoglobin, Type 1 diabetes, Fibronectin Type III Domain Containing 5, business.industry, Case-control study, nutritional and metabolic diseases, RC648-665, medicine.disease, Fibronectins, 030104 developmental biology, Diabetes Mellitus, Type 1, chemistry, Hyperglycemia, Case-Control Studies, Multivariate Analysis, Linear Models, Hemoglobin, business, IAnti-Glutamic Acid Decarboxylase

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4f112b01260ba5da9a0d737b569048Test
https://pubmed.ncbi.nlm.nih.gov/28222023Test

10

Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans

المؤلفون: Christopher R. Parish, J. Dennis Wilson, Helen E. Thomas, Fui Jiun Choong, Barbara Ludwig, Andrew F. Ziolkowski, Charmaine J. Simeonovic, Sarah K. Popp, Stefan R. Bornstein, Thomas W.H. Kay, Lora Starrs, Craig Freeman, Thomas Loudovaris, Debra J. Brown, Alberto Pugliese

المساهمون: University of Zurich, Simeonovic, Charmaine J

المصدر: PLoS ONE, Vol 13, Iss 2, p e0191360 (2018)
PLoS ONE

مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system diseases, medicine.medical_treatment, 10265 Clinic for Endocrinology and Diabetology, lcsh:Medicine, Biochemistry, White Blood Cells, chemistry.chemical_compound, Endocrinology, Spectrum Analysis Techniques, 0302 clinical medicine, Animal Cells, Medicine and Health Sciences, Insulin, Child, lcsh:Science, Cells, Cultured, Staining, Multidisciplinary, geography.geographical_feature_category, Chemistry, Cell Staining, Drugs, Heparan sulfate, Flow Cytometry, Islet, 3. Good health, medicine.anatomical_structure, Spectrophotometry, Child, Preschool, Disease Progression, Female, Cytophotometry, Anatomy, Cellular Types, medicine.symptom, Beta cell, Biliary Disorders, Research Article, Adult, medicine.medical_specialty, endocrine system, Adolescent, Endocrine Disorders, Immune Cells, Immunology, Endocrine System, 030209 endocrinology & metabolism, Inflammation, 610 Medicine & health, Gastroenterology and Hepatology, 1100 General Agricultural and Biological Sciences, Research and Analysis Methods, Sensitivity and Specificity, Islets of Langerhans, Young Adult, 03 medical and health sciences, Exocrine Glands, 1300 General Biochemistry, Genetics and Molecular Biology, Internal medicine, Diabetes Mellitus, medicine, Humans, Heparanase, Pancreas, Pharmacology, Diabetic Endocrinology, geography, 1000 Multidisciplinary, Blood Cells, Heparin, Pancreatic islets, lcsh:R, Biology and Life Sciences, Infant, Cell Biology, medicine.disease, Hormones, Diabetes Mellitus, Type 1, 030104 developmental biology, Specimen Preparation and Treatment, Metabolic Disorders, Case-Control Studies, lcsh:Q, Heparitin Sulfate, Insulitis, Biomarkers

وصف الملف: pone.0191360.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b710034fc5ae324ee64bd93770d4b09fTest
http://europepmc.org/articles/PMC5802856?pdf=renderTest

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