Anti-apoptotic peptide for long term cardioprotection in a mouse model of myocardial ischemia–reperfusion injury
| العنوان: | Anti-apoptotic peptide for long term cardioprotection in a mouse model of myocardial ischemia–reperfusion injury |
|---|---|
| المؤلفون: | S. Barrere-Lemaire, Anne Vincent, Christian Barrère, Bernard Lebleu, Christophe Piot, Prisca Boisguerin, Joël Nargeot, Aurélie Covinhes, Laura Gallot, Catherine Sportouch |
| المساهمون: | Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), LabEx Ion Channel Science and Therapeutics, Clinique du Millénaire - Oc Santé [Montpellier], Oc Santé [Montpellier], LPHI - Laboratory of Pathogen Host Interactions (LPHI), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en Biologie cellulaire de Montpellier (CRBM), Guerineau, Nathalie C. |
| المصدر: | Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-75154-x⟩ Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-75154-x⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, [SDV]Life Sciences [q-bio], lcsh:Medicine, Peptide, Apoptosis, Myocardial Reperfusion Injury, 030204 cardiovascular system & hematology, Pharmacology, Article, Target validation, 03 medical and health sciences, Mice, 0302 clinical medicine, Reperfusion therapy, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Troponin I, medicine, Animals, Myocardial infarction, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Cardioprotection, chemistry.chemical_classification, Multidisciplinary, Ejection fraction, business.industry, lcsh:R, medicine.disease, Peptide Fragments, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, chemistry, lcsh:Q, business, Reperfusion injury |
| الوصف: | Reperfusion therapy during myocardial infarction (MI) leads to side effects called ischemia–reperfusion (IR) injury for which no treatment exists. While most studies have targeted the intrinsic apoptotic pathway to prevent IR injury with no successful clinical translation, we evidenced recently the potent cardioprotective effect of the anti-apoptotic Tat-DAXXp (TD) peptide targeting the FAS-dependent extrinsic pathway. The aim of the present study was to evaluate TD long term cardioprotective effects against IR injury in a MI mouse model. TD peptide (1 mg/kg) was administered in mice subjected to MI (TD; n = 21), 5 min prior to reperfusion, and were clinically followed-up during 6 months after surgery. Plasma cTnI concentration evaluated 24 h post-MI was 70%-decreased in TD (n = 16) versus Ctrl (n = 20) mice (p***). Strain echocardiography highlighted a 24%-increase (p****) in the ejection fraction mean value in TD-treated (n = 12) versus Ctrl mice (n = 17) during the 6 month-period. Improved cardiac performance was associated to a 54%-decrease (p**) in left ventricular fibrosis at 6 months in TD (n = 16) versus Ctrl (n = 20). In conclusion, targeting the extrinsic pathway with TD peptide at the onset of reperfusion provided long-term cardioprotection in a mouse model of myocardial IR injury by improving post-MI cardiac performance and preventing cardiac remodeling. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac8b9a94382c6fc0ff74df04e94012fTest https://hal.archives-ouvertes.fr/hal-02996282Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4ac8b9a94382c6fc0ff74df04e94012f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|