Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial
| العنوان: | Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial |
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| المؤلفون: | Isabelle Chereau, Fanny Melis, Pierre-Michel Llorca, Motassem Bakri, Thierry Lucas, Yohan Souchet, Emmanuelle Pages, Sophie Morel, F. Gabayet, Celine Roussel, Catherine Massoubre, Romain Rey, Julien Dubreucq, Mégane Faraldo, Titaua Challe, Bernard Ycart, B. Arnaud, Florian Carmona, G Legrand, Sylvie Pires, Philippe Lamy, Gentiane Cambier, Romain Pommier, Mickael Bacconnier |
| المساهمون: | Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère], Centre Hospitalier Alpes Isère, Fondation FondaMental [Créteil], Réseau Handicap Psychique RéHPSY, Statistique pour le Vivant et l’Homme (SVH), Laboratoire Jean Kuntzmann (LJK), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Clermont-Ferrand, Etablissement médical de La Teppe, Centre de Réhabilitation Psychosociale et de Remédiation Cognitive, CH Drome Vivarais, Centre Hospitalier Spécialisé de la Savoie, REHALise, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Départemental de Réhabilitation Psychosociale des Glières, Centre Hospitalier le Vinatier [Bron], Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (ISC-MJ), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E) |
| المصدر: | European Psychiatry European Psychiatry, Cambridge University press, 2020, 63 (1), pp.599-610. ⟨10.1192/j.eurpsy.2020.42⟩ European Psychiatry, 2020, 63 (1), pp.599-610. ⟨10.1192/j.eurpsy.2020.42⟩ |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Physical fitness, Psychological intervention, social cognitive remediation, Social Skills, 03 medical and health sciences, 0302 clinical medicine, touchrugby, Medicine, Humans, Social Behavior, Positive and Negative Syndrome Scale, business.industry, Aggression, Physical activity, Cognition, medicine.disease, Combined Modality Therapy, Cognitive Remediation, 030227 psychiatry, 3. Good health, Exercise Therapy, schizophrenia, Psychiatry and Mental health, Schizophrenia, social function, Female, medicine.symptom, business, Psychosocial, 030217 neurology & neurosurgery, Social cognitive theory, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Clinical psychology, Follow-Up Studies, Research Article |
| الوصف: | Background.Functional capacity (FC) has been identified as a key outcome to improve real-world functioning in schizophrenia. FC is influenced by cognitive impairments, negative symptoms, self-stigma and reduced physical activity (PA). Psychosocial interventions targeting FC are still under-developed.Methods.we conducted a quasi-experimental study evaluating the effects of an exercise-enriched integrated social cognitive remediation (SCR) intervention (RemedRugby [RR]) compared with an active control group practicing Touch Rugby (TR). To our knowledge, this is the first trial to date evaluating the effectiveness of such a program provided in a real-life environment.Results.Eighty-seven people with schizophrenia were included and allocated to either the RR group (n= 57) or the TR group (n= 30) according to the routine clinical practice of the recruiting center. Outcomes were evaluated at baseline and post-treatment in both groups and after 6 months of follow-up in the RR group using standardized scales for symptom severity, social functioning, self-stigma, and a large cognitive battery. After treatment we observed moderate to large improvements in social function (Personal and Social Performance Scale [PSP],p< 0.001,d= 1.255), symptom severity (Positive and Negative Syndrome Scale [PANSS] negative,p< 0.001,d= 0.827; PANSS GP,p< 0.001,d= 0.991; PANSS positive,p= 0.009,d= 0.594), verbal abstraction (p= 0.008,d= 0.554), aggression bias (p= 0.008,d= 0.627), and self-stigma (stereotype endorsement,p= 0.019,d= 0.495; discrimination experiences,p= 0.047;d= 0.389) that were specific to the RR group and were not observed in participants playing only TR. Effects were persistent over time and even larger between post-treatment and follow-up.Conclusions.Exercise-enriched integrated SCR appears promising to improve real-life functioning in schizophrenia. Future research should investigate the potential effects of this intervention on neuroplasticity and physical fitness. |
| تدمد: | 1778-3585 0924-9338 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5275adc73dfe4cf676bf8b217603bd2bTest https://pubmed.ncbi.nlm.nih.gov/32349835Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5275adc73dfe4cf676bf8b217603bd2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17783585 09249338 |
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