Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
| العنوان: | Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease |
|---|---|
| المؤلفون: | David Rodriguez-Luna, Soledad Pérez-Sánchez, Pere Cardona Portela, Joan Montaner, Olalla Pancorbo, Rocío Vera, Silvia Tur, Maria Del Mar Freijo, Anna Bonaterra-Pastra, José Luis Sánchez-Quesada, Andrea Rivas-Urbina, Lucia Lebrato-Hernández, Juan F. Arenillas, Núria Puig, Sofia Fernández-de-Retana, Maite Martínez-Zabaleta, Sonia Benitez, Mar Hernández-Guillamon, Francesc Pujadas |
| المساهمون: | Institut Català de la Salut, [Bonaterra-Pastra A, Fernández-de-Retana S, Hernández-Guillamon M] Laboratori de recerca neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rivas-Urbina A, Puig N, Benítez S] Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau (IIB Sant Pau), Barcelona, Spain. [Pancorbo O, Rodríguez-Luna D] Grup de Recerca en Ictus, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Pujadas F] Unitat de Demència, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Montaner J] Laboratori de recerca neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Stroke Unit, Virgen del Rocío University Hospital, Sevilla, Spain. Department of Neurology, Virgen Macarena University Hospital, Sevilla, Spain. Stroke Research Program, Institute of Biomedicine of Sevilla, IBiS, Sevilla, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Biomedicines Volume 9 Issue 1 Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Dipòsit Digital de la UB Universidad de Barcelona Scientia Biomedicines, Vol 9, Iss 72, p 72 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Apolipoprotein E, Very low-density lipoprotein, Lipoproteïnes, Medicine (miscellaneous), Proteinas, Amino Acids, Peptides, and Proteins::Proteins::Lipoproteins [CHEMICALS AND DRUGS], 0302 clinical medicine, Alzheimer, Enfermedad de, Senile plaques, lcsh:QH301-705.5, Nervous System Diseases::Central Nervous System Diseases::Brain Diseases [DISEASES], Otros calificadores::Otros calificadores::/metabolismo [Otros calificadores], medicine.diagnostic_test, Lípidos, Other subheadings::Other subheadings::/metabolism [Other subheadings], Amyloidosis, Alzheimer's disease, Lipids, Lipoproteïnes de la sang - Metabolisme, Lipid profile, lipid profile, Neurology, Cervell - Malalties, aminoácidos, péptidos y proteínas::proteínas::lipoproteínas [COMPUESTOS QUÍMICOS Y DROGAS], 3207.11 Neuropatología, lipids (amino acids, peptides, and proteins), Cerebral amyloid angiopathy, Alzheimer’s disease, medicine.medical_specialty, Lipoproteins, Article, General Biochemistry, Genetics and Molecular Biology, s disease, 03 medical and health sciences, Lipoprotein composition, Internal medicine, Parenchyma, mental disorders, medicine, cardiovascular diseases, Cerebro - Enfermedades, Alzheimer’, cerebral amyloid angiopathy, Intracerebral hemorrhage, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales [ENFERMEDADES], business.industry, lipoprotein composition, Proteins, nutritional and metabolic diseases, medicine.disease, 030104 developmental biology, Endocrinology, Malaltia d'Alzheimer, Apolipoproteins, lcsh:Biology (General), Amiloïdosi, business, apolipoproteins, 030217 neurology & neurosurgery, Lipoprotein |
| الوصف: | Producción Científica Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer’s disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation. Instituto de Salud Carlos III y Fondo Europeo de Desarrollo Regional (FEDER) - (grant PI13/00364, PI16/00471, PI14/01134 and PI17/00275) Instituto de Salud Carlos III - (grant FI17/00031) Instituto de Salud Carlos III, Programa Miguel Servet - (grant CPII17/00010) Instituto de Salud Carlos III - (project RD16/0019/0021) Generalitat de Catalunya - (Grupo 2017-SGR-1149) |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2227-9059 |
| DOI: | 10.3390/biomedicines9010072 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc639fcb01043ee096414c21da75b296Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bc639fcb01043ee096414c21da75b296 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22279059 |
|---|---|
| DOI: | 10.3390/biomedicines9010072 |