التفاصيل البيبلوغرافية
العنوان:
Randomized Trial of Thymectomy in Myasthenia Gravis
المؤلفون:
Wolfe, Gi , Kaminski, Hj , Aban, Ib , Minisman, G , Kuo, Hc , Marx, A , Ströbel, P , Mazia, C , Oger, J , Cea, Jg , Heckmann, Jm , Evoli, A , Nix, W , Ciafaloni, E , Antonini, G , Witoonpanich, R , King, Jo , Beydoun, Sr , Chalk, Ch , Barboi, Ac , Amato, Aa , Shaibani, Ai , Katirji, B , Lecky, Br , Buckley, C , Vincent, A , Dias Tosta, E , Yoshikawa, H , Waddington Cruz, M , Pulley, Mt , Rivner, Mh , Kostera Pruszczyk, A , Pascuzzi, Rm , Jackson, Ce , Garcia Ramos GS , Verschuuren, Jj , Massey, Jm , Kissel, Jt , Werneck, Lc , Benatar, M , Barohn, Rj , Tandan, R , Mozaffar, T , Conwit, R , Odenkirchen, J , Sonett, Jr , 3rd, Jaretzki A. , Newsom Davis, J , Cutter, Gr , MGTX study group including Cutter GR , Feese, M , Saluto, V , Rosenberg, M , Alvarez, V , Rey, L , King, J , Butzkueven, H , Goldblatt, J , Carey, J , Pollard, J , Reddel, S , Handel, N , Mccaughan, B , Pallot, L , Novis, R , Boasquevisque, C , Morato Fernandez, R , Ximenes, M , Werneck, L , Scola, R , Soltoski, P , Chalk, C , Moore, F , Mulder, D , Wadup, L , Mezei, M , Evans, K , Jiwa, T , Schaffar, A , White, C , Toth, C , Gelfand, G , Wood, S , Pringle, E , Zwicker, J , Maziak, D , Shamji, F , Sundaresan, S , Seely, A , Cea, G , Verdugo, R , Aguayo, A , Jander, S , Zickler, P , Klein, M , Weis, Ca , Melms, A , Bischof, F , Aebert, H , Ziemer, G , Thümler, B , Wilhem Schwenkmezger, T , Mayer, E , Schalke, B , Pöschel, P , Hieber, G , Wiebe, K , Clemenzi, A , Ceschin, V , Rendina, E , Venuta, F , Morino, S , Bucci, E , Durelli, Luca , Tavella, A , Clerico, Marinella , Contessa, G , Borasio, P , Servidei, S , Granone, P , Mantegazza, R , Berta, E , Novellino, L , Spinelli, L , Motomura, M , Matsuo, H , Nagayasu, T , Takamori, M , Oda, M , Matsumoto, I , Furukawa, Y , Noto, D , Motozaki, Y , Iwasa, K , Yanase, D , Ramos, Gg , Cacho, B , de la Garza, L , Lipowska, M , Kwiecinski, H , Potulska Chromik, A , Orlowski, T , Silva, A , Feijo, M , Freitas, A , Heckmann, J , Frost, A , Pan, El , Tucker, L , Rossouw, J , Drummond, F , Illa, I , Diaz, J , Leon, C , Yeh, Jh , Chiu, Hc , Hsieh, Ys , Tunlayadechanont, S , Attanavanich, S , Verschuuren, J , Straathof, C , Titulaer, M , Versteegh, M , Pels, A , Krum, Y , Leite, M , Hilton Jones, D , Ratnatunga, C , Farrugia, Me , Petty, R , Overell, J , Kirk, A , Gibson, A , Mcdermott, C , Hopkinson, D , Lecky, B , Watling, D , Marshall, D , Saminaden, S , Davies, D , Dougan, C , Sathasivam, S , Page, R , Sussman, J , Ealing, J , Krysiak, P , Amato, A , Salajegheh, M , Jaklitsch, M , Roe, K , Ashizawa, T , Smith, Rg , Zwischenberg, J , Stanton, P , Barboi, A , Jaradeh, S , Tisol, W , Gasparri, M , Haasler, G , Yellick, M , Dennis, C , Barohn, R , Pasnoor, M , Dimachkie, M , Mcvey, A , Gronseth, G , Dick, A , Kramer, J , Currence, M , Herbelin, L , Belsh, J , Li, G , Langenfeld, J , Mertz, Ma , Harrison, T , Force, S , Usher, S , Beydoun, S , Lin, F , Demeester, S , Akhter, S , Malekniazi, A , Avenido, G , Crum, B , Milone, M , Cassivi, S , Fisher, J , Heatwole, C , Watson, T , Hilbert, J , Smirnow, A , Distad, B , Weiss, M , Wood, D , Haug, J , Ernstoff, R , Cao, J , Chmielewski, G , Welsh, R , Duris, R , Gutmann, L , Pawar, G , Graeber, Gm , Altemus, P , Nance, C , Jackson, C , Grogan, P , Calhoon, J , Kittrell, P , Myers, D , Kaminski, H , Hayat, G , Naunheim, K , Eller, S , Holzemer, E , Alshekhlee, A , Robke, J , Karlinchak, B , Katz, J , Miller, R , Roan, R , Forshew, D , Kissel, J , Elsheikh, B , Ross, P , Chelnick, S , Lewis, R , Acsadi, A , Baciewicz, F , Masse, S , Massey, J , Juel, V , Onaitis, M , Lowe, J , Lipscomb, B , Thai, G , Milliken, J , Martin, V , Karayan, R , Muley, S , Parry, G , Shumway, S , Oh, S , Claussen, G , Lu, L , Cerfolio, R , Young, A , Morgan, M , Pascuzzi, R , Kincaid, J , Kesler, K , Guingrich, S , Michaels, A , Phillips, L , Burns, T , Jones, D , Fischer, C , Pulley, M , Berger, A , D'Agostino, H , Smith, L , Rivner, M , Pruitt, J , Landolfo, K , Hillman, D , Shaibani, A , Sermas, A , Ruel, R , Ismail, F , Sivak, M , Goldstein, M , Camunas, J , Bratton, J , Panitch, H , Leavitt, B , Jones, M , Wolfe, G , Muppidi, S , Vernino, S , Nations, S , Meyer, D , Gorham, N.
المصدر:
The New England journal of medicine, vol 375, iss 6
سنة النشر:
2016
مصطلحات موضوعية:
Male , medicine , medicine.medical_treatment , 030204 cardiovascular system & hematology , Medical and Health Sciences , Severity of Illness Index , law.invention , 0302 clinical medicine , Randomized controlled trial , law , Prednisone , Adolescent , Adult , Aged , Combined Modality Therapy , Female , Glucocorticoids , Hospitalization , Humans , Middle Aged , Myasthenia Gravis , Single-Blind Method , Treatment Outcome , Young Adult , Thymectomy , Medicine (all) , Young adult , MGTX Study Group , General Medicine , Settore MED/26 - NEUROLOGIA , 6.1 Pharmaceuticals , medicine.drug , medicine.medical_specialty , Clinical Trials and Supportive Activities , Autoimmune Disease , 03 medical and health sciences , Rare Diseases , Clinical Research , General & Internal Medicine , Internal medicine , Severity of illness , business.industry , Neurosciences , Evaluation of treatments and therapeutic interventions , Retrospective cohort study , medicine.disease , Myasthenia gravis , Surgery , Clinical research , adolescent , adult , aged , combined modality therapy , female , glucocorticoids , hospitalization , humans , male , middle aged , myasthenia gravis , prednisone , severity of Illness index , single-blind method , treatment outcome , young adult , thymectomy , business , 030217 neurology & neurosurgery
الوصف:
BackgroundThymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence of its benefit. We conducted a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone.MethodsWe compared extended transsternal thymectomy plus alternate-day prednisone with alternate-day prednisone alone. Patients 18 to 65 years of age who had generalized nonthymomatous myasthenia gravis with a disease duration of less than 5 years were included if they had Myasthenia Gravis Foundation of America clinical class II to IV disease (on a scale from I to V, with higher classes indicating more severe disease) and elevated circulating concentrations of acetylcholine-receptor antibody. The primary outcomes were the time-weighted average Quantitative Myasthenia Gravis score (on a scale from 0 to 39, with higher scores indicating more severe disease) over a 3-year period, as assessed by means of blinded rating, and the time-weighted average required dose of prednisone over a 3-year period.ResultsA total of 126 patients underwent randomization between 2006 and 2012 at 36 sites. Patients who underwent thymectomy had a lower time-weighted average Quantitative Myasthenia Gravis score over a 3-year period than those who received prednisone alone (6.15 vs. 8.99, P
وصف الملف:
application/pdf
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253ed893891f069ca7bfcc4b30f12214Test https://doi.org/10.1056/nejmoa1602489Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....253ed893891f069ca7bfcc4b30f12214
قاعدة البيانات:
OpenAIRE
