المؤلفون: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NCBI, National Center for Biotechnology Information, TALEN, transcriptional activators like effector nucleases, RNP, ribonucleoprotein, Review, Gene editing, SREBP-2, sterol regulatory element-binding protein 2, 0302 clinical medicine, AAV, adeno-associated virus, Genome editing, DDI, drug–drug interaction, CRISPR, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, HDR, homology directed repair, tracRNA, trans-activating crRNA, ADMET, absorption, distribution, metabolism, excretion and toxicity, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, CRISPR-Cas9, OATP1B, organic anion transporting polypeptides 1B, Rat model, CRISPR-Cas, clustered regularly interspaced short palindromic repeats-CRISPR-associated, pre-crRNA, pre-CRISPR RNA, Computational biology, RM1-950, 03 medical and health sciences, Animal model, Pharmacokinetics, TALE, transcriptional activator-like effector, ZFN, zinc finger nucleases, DSB, double-strand break, PAM, protospacer-associated motif, Gene knockout, BSEP, bile salt export pump, 030304 developmental biology, Drug metabolism, KO, knockout, Mechanism (biology), sgRNA, single guide RNA, crRNAs, CRISPR RNAs, WT, wild-type, HBV, hepatitis B virus, T7E I, T7 endonuclease I, NHEJ, non-homologous end joining, SD, Sprague–Dawley, OTS, off-target site, DMPK, drug metabolism and pharmacokinetics, Therapeutics. Pharmacology, HPV, human papillomaviruses

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953da916a138cd7d6b71c2e8c8f9668aTest
http://www.sciencedirect.com/science/article/pii/S2211383521000113Test

المؤلفون: Shaheen Akhtar, Joanna Bottomley, Edward Ryder, Daniel M Barrett, Michaela Bruntraeger, Sanger Mouse Genetics, James Bussell, Jonathan Burvill, Radka Platte, Debarati Sethi, Diane Gleeson

المصدر: Methods (San Diego, Calif.)

مصطلحات موضوعية: FASTQ format, Genotyping, Genotype, Genotyping Techniques, Mouse, Computational biology, Biology, Polymerase Chain Reaction, Genome, Article, General Biochemistry, Genetics and Molecular Biology, DNA sequencing, Mice, 03 medical and health sciences, PCR, polymerase chain reaction, Animals, CRISPR, CRISPR, clustered regularly interspaced short palindromic repeat, hom, homozygous, Allele, Molecular Biology, Alleles, QC, 030304 developmental biology, 0303 health sciences, fungi, 030302 biochemistry & molecular biology, sgRNA, single guide RNA, Mutant, food and beverages, High-Throughput Nucleotide Sequencing, NGS, next generation sequencing, het, heterozygous, Amplicon, WT, wild-type, Mice, Mutant Strains, QC, quality control, NHEJ, non-homologous end joining, NGS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef79b367f901763da5e833510b51bcdcTest
https://doi.org/10.1016/j.ymeth.2020.10.011Test

المؤلفون: Liwu Fu, Hong Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1400-1411 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: FANCD2, Fanconi anemia protein, DFS, disease-free survival, HNC, head and neck cancer, Cancer therapy, Review, medicine.disease_cause, SCC, squamous cell carcinoma, Metastasis, εPKC, epsilon protein kinase C, 0302 clinical medicine, NAD, nicotinamide adenine dinucleotide, Polymorphism (computer science), PdG, N2-propano-2′-deoxyguanosine, EC, esophageal cancer, General Pharmacology, Toxicology and Pharmaceutics, FA, Fanconi anemia, Cancer, TGF-β, transforming growth factor β, 0303 health sciences, Progression, GCA, gastric cancer, NRF2, nuclear factor erythroid 2 (NF-E2)-related factor 2, ccRCC, clear-cell renal cell carcinomas, NHEJ, non-homologous end-joining, PC, pancreatic cancer, 030220 oncology & carcinogenesis, CRC, colorectal cancer, NeG, 1,N2-etheno-dGuo, PBMC, peripheral blood mononuclear cell, ALD, alcoholic liver disease, CSCs, cancer stem cells, OvCa, ovarian cancer, COUP-TF, chicken ovalbumin upstream promoter-transcription factor, BCa, bladder cancer, NF-κB, nuclear factor-κB, Single-nucleotide polymorphism, Acetaldehyde, RM1-950, 4-HNE, 4-hydroxy-2-nonenal, OS, overall survival, 03 medical and health sciences, NSCLC, non-small-cell lung, medicine, SNP, MN, micronuclei, Polymorphism, ALDH2, 030304 developmental biology, LCSCs, liver cancer stem cells, MDA, malondialdehyde, business.industry, ALDH2, aldehyde dehydrogenase 2, MDR, multi-drug resistance, OPC, oropharyngeal cancer, HDACs, histone deacetylases, medicine.disease, AMPK, AMP-activated protein kinase, VHL, von Hippel-Lindau, Tumor progression, REV1, Y-family DNA polymerase, NER, nucleotide excision repair pathway, NRRE, nuclear receptor response element, Tumorigenesis, Cancer research, NCEs, normochromic erythrocytes, Therapeutics. Pharmacology, HR, homologous recombination, HCC, hepatocellular carcinoma, business, Carcinogenesis, HNF-4, hepatocyte nuclear factor 4

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd88ae6dedbdf2435fcfad1324d1900Test
https://doi.org/10.1016/j.apsb.2021.02.008Test

المؤلفون: Shikang Liang, Tom L. Blundell, Amanda K. Chaplin, Aleš Hnízda, Antonia Kefala Stavridi, Robert Appleby

المساهمون: Liang, Shikang [0000-0002-6930-7882], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository

المصدر: Progress in Biophysics and Molecular Biology

مصطلحات موضوعية: Materials science, DNA End-Joining Repair, Spatial organisation, DNA Repair, Cryo-electron microscopy, DNA repair, Double-strand breaks, 030303 biophysics, Biophysics, KBM, Ku-binding motif, Computational biology, Article, 03 medical and health sciences, chemistry.chemical_compound, DNA-PK, DNA-dependent protein kinase, PAXX, Paralog of XRCC4 and XLF, XLF, XRCC4-Like Factor, Stages, Strings, Humans, DSB, double-strand break, DNA Breaks, Double-Stranded, Orchestration (computing), vWA, von Willebrand factor type A, cryo-EM, cryo-electron microscopy, PTIP, Pax transcription-activation-domain interacting protein, Molecular Biology, NHEJ, Cryo-EM, IR, ionising radiation, Scaffolds, 0303 health sciences, 53BP1, p53-binding protein 1, Cryoelectron Microscopy, X-ray diffraction, Non-homologous end joining, enzymes and coenzymes (carbohydrates), chemistry, DNA-PKcs, DNA-PK catalytic subunit, NHEJ, non-homologous end joining, X-ray crystallography, PNKP, polynucleotide kinase, APLF, aprataxin and PNKP-like factor, BRCT, BRCA1 C-Terminus domain, lncRNA, long noncoding RNA, HR, homologous recombination, DNA, CTR, C-terminal region

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca43e6e448ffae277c09ed2c9f19bd34Test
https://www.repository.cam.ac.uk/handle/1810/316479Test

المؤلفون: Danielle G. Passos-Silva, Elizângela Almeida Rocha, Dawidson Assis Gomes, Joao P. Vieira-da-Rocha, Richard McCulloch, Carlos Renato Machado, Isabela Cecília Mendes

المصدر: DNA Repair

مصطلحات موضوعية: Alkylation, DNA Repair, RAD51, DNA damage response, Biochemistry, DNA Adducts, chemistry.chemical_compound, 0302 clinical medicine, ICL, interstrand crosslink, kDNA, kinetoplast DNA, BER, base excision repair, 0303 health sciences, biology, PCF, procyclic form, Cell cycle, Cell biology, MMS, methyl methanesulfonate, 030220 oncology & carcinogenesis, Kinetoplast, BSF, bloodstream form, Mitochondrial DNA, DNA damage, DNA repair, Life cycle, Trypanosoma brucei brucei, Replication, MMR, mismatch repair, Trypanosoma brucei, Trypanosome, Article, PI, propidium iodide, 03 medical and health sciences, NER, nucleotide excision repair, parasitic diseases, TLS, translesion synthesis, Molecular Biology, DR, direct repair, 030304 developmental biology, Cell Cycle Checkpoints, Cell Biology, DNA, Protozoan, biology.organism_classification, Oxidative Stress, chemistry, NHEJ, non-homologous end joining, DSBs, double strand breaks, Rad51 Recombinase, HR, homologous recombination, nDNA, nuclear DNA, VSG, variant surface glycoprotein, Repair, DNA, DNA Damage

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865a1261c26a5c5116370ba7eff05f6eTest
https://doi.org/10.1016/j.dnarep.2018.11.005Test

المؤلفون: Hongquan Guo, Xinfeng Liu, Juanji Li, Xiaolei Shi, Yi Xie, Pengfei Xu, Yunzi Li, Qian Liu, Rui Sun, Ye Hong, Mengna Peng, Gelin Xu

المصدر: Redox Biology
Redox Biology, Vol 18, Iss, Pp 158-172 (2018)

مصطلحات موضوعية: 0301 basic medicine, BRCT, BRCA1 C-terminal, GPX3, glutathione peroxidase 3, 4-HNE, 4-hydroxynonenol, OGD, oxygen-glucose deprivation, GCLM, glutamate-cysteine ligase regulator subunit, Iba-1, ionized calcium-binding adapter molecule-1, Clinical Biochemistry, SOD1, superoxide dismutase 1, HO-1, heme oxygenase 1, medicine.disease_cause, Biochemistry, NPCs, neural precursor cells, CaMKII, calcium/calmodulin-dependent protein kinase II, Lipid peroxidation, chemistry.chemical_compound, CA1, cornu ammonis 1, NSCs, neural stem cells, 3-NT, 3-nitrotyrosine, XRE, xenobiotic responsive element, skin and connective tissue diseases, lcsh:QH301-705.5, BER, base excision repair, GFP, green fluorescent protein, PSD95, postsynaptic density protein 95, chemistry.chemical_classification, lcsh:R5-920, DCX, doublecortin, ALS, amyotrophic lateral sclerosis, NRF2, nuclear factor (erythroid-derived 2)-like 2, GPX4, glutathione peroxidase 4, 8-OHDG, 8-hydroxy-2′-deoxyguanosine, Signal transduction, lcsh:Medicine (General), Ischemia/Reperfusion, Research Paper, NQO1, NAD(P)H dehydrogenase (quinone 1), DNA damage, DNA repair, Ischemia, I/R, ischemia/reperfusion, CNS, central nervous system, GCLC, glutamate-cysteine ligase catalytic, NRF2, 03 medical and health sciences, ROS, reactive oxygen species, NER, nucleotide excision repair, medicine, MCAO, middle cerebral artery occlusion, SOD2, superoxide dismutase 2, Reactive oxygen species, AD, Alzheimer disease, Organic Chemistry, GFAP, glial fibrillary acidic protein, BRCA1, medicine.disease, ARE, antioxidative response element, 030104 developmental biology, lcsh:Biology (General), chemistry, NHEJ, non-homologous end joining, Oxidative stress, BRCA1, breast cancer susceptibility protein 1, DSBs, double strand breaks, Cancer research, HR, homologous recombination, Reperfusion injury

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e034e7c5102b1e7cd98f372f511aacTest
https://doi.org/10.1016/j.redox.2018.06.012Test

المؤلفون: Anja A. Kühl, Monique R. Bernsen, Winfried Brenner, M. Welzel, Richard P. Baum, Samantha Exner, Eva J. Koziolek, Jakob Albrecht, Dagmar Sedding, Patricia Grabowski, Christian Fischer, Fränze Schmidt, Teresa Hartung, Joost C. Haeck, Franziska Briest, Carsten Grötzinger

المساهمون: Radiology & Nuclear Medicine

المصدر: Neoplasia (New York, N.Y.)
BASE-Bielefeld Academic Search Engine
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 80-98 (2021)
Neoplasia (United States), 23(1), 80-98

مصطلحات موضوعية: Apoptosis, FOXO3a, forkheadbox protein O3a, d, day(s), Rb, retinoblastoma protein, Mice, 0302 clinical medicine, JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide, Molecular Targeted Therapy, BER, base excision repair, Bortezomib, IC50, dose of half-maximum inhibitory effect, Ga-68, Gallium-68, Drug Synergism, DSMZ, Deutsche Sammlung für Mikroorganismen und Zellen, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Neuroendocrine Tumors, G0/1/2 phase, gap phase 0/1/2, 030220 oncology & carcinogenesis, CAM, chorioallantoic membrane, (M)Bq, (Mega-)Becquerel, Original article, PRRT, peptide receptor radionuclide therapy, DNA damage, p70S6K, ribosomal protein S6 kinase, DNA repair, Antineoplastic Agents, NEN, neuroendocrine neoplasms, ERK, extracellular-signal-regulated kinase, lcsh:RC254-282, AP-sides, apurinic or apyrimidinic sites, M phase, mitosis phase, 03 medical and health sciences, SDG 3 - Good Health and Well-being, In vivo, i.v., intravenous, NER, nucleotide excision repair, GO, Gene Ontology, Humans, Combination therapy, FOXM1, forkheadbox protein M1, Cisplatin, G1/2/3, grade 1/2/3, Dose-Response Relationship, Drug, Proteasome inhibition, Cell Cycle Checkpoints, n, number, H2AX, histone H2AX, 030104 developmental biology, Proteasome, NHEJ, non-homologous end joining, g, gram, Proteasome inhibitor, HR, homologous recombination, 0301 basic medicine, Cancer Research, BRIP1, BRCA1 Interacting Protein C-Terminal Helicase 1, Chick Embryo, RPA, replication protein A, GEP-NEN, gastroenteropancreatic neuroendocrine neoplasms, SCLC, small cell lung cancer, Gene Regulatory Networks, TGF, transforming growth factor, HTCA, human tumor colony assay, Gastrointestinal Neoplasms, i.p., intraperitoneal, M, molar, Lu-177, Lutetium-177, Proteasome Inhibitors, F-18-FDG-PET, 2-deoxy-2-(F-18)fluoro-D-glucose positron emission tomography, SSTR2, somatostatin receptor 2, PI3K, phosphoinositide 3-kinase, medicine.drug, DDR, DNA damage repair, MMR, mismatch repair, SKP2, S-Phase Kinase Associated Protein 2, PARP1, poly(ADP-ribose) polymerase 1, (RT)-PCR, (real-time) polymerase chain reaction, BRCA1/2, breast cancer protein 1/2, ER, endoplasmic reticulum, ROS, reactive oxygen species, S phase, synthesis phase, Cell Line, Tumor, h, hour(s), medicine, Animals, TLS, translesion synthesis, Cell Proliferation, business.industry, DSB, double-strand breaks, PTEN, phosphatase and tensin homolog, CK2, casein kinase 2, Drug Resistance, Neoplasm, Radionuclide therapy, SSB, single-strand breaks, Cancer research, business, MRI, magnetic resonance imaging, DNA Damage, Peptide receptor radionuclide therapy (PRRT)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b0fcaaba5da9ca61e63d327232b0b4Test
http://www.scopus.com/inward/record.url?scp=85096683387&partnerID=8YFLogxKTest

المؤلفون: Ryohei Yasuda, Hirofumi Nishizono, Tal Laviv

المصدر: Frontiers in Genome Editing, Vol 2 (2020)
Frontiers in Genome Editing

مصطلحات موضوعية: 0301 basic medicine, lcsh:QH426-470, Transgene, lcsh:Biotechnology, Computational biology, Review, Biology, Synapse, 03 medical and health sciences, 0302 clinical medicine, Genome editing, lcsh:TP248.13-248.65, CRISPR, Genome Editing, HDR (homology-directed repair), Cas9, HITI (homology-independent targeted integration), Mammalian brain, lcsh:Genetics, 030104 developmental biology, NHEJ (non-homologous end joining), Cell bodies, SLENDR (single-cell labeling of endogenous proteins with homology-directed repair), 030217 neurology & neurosurgery, Function (biology), iGONAD (improved-genome editing via oviductal nucleic acids delivery)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027c58a5665dd5ba08f49e23d2a47fe5Test
https://www.frontiersin.org/articles/10.3389/fgeed.2020.602970/fullTest

المؤلفون: Leszek Lisowski, Sophia H.Y. Liao, Szun S. Tay, Ian E. Alexander, Grant J Logan, Samantha L. Ginn, Claus V. Hallwirth, Markus Grompe, Anais K. Amaya, Erhua Zhu, Hilda A. Pickett, Kimberley L. Dilworth, Anthony J. Cesare, Sharon C. Cunningham, Michael Lee

المصدر: JHEP Reports, Vol 2, Iss 1, Pp-(2020)
JHEP Reports

مصطلحات موضوعية: Genetic enhancement, ITR, inverted terminal repeats, medicine.disease_cause, RTA, Real Time Analysis, BrdU, bromodeoxyuridine, AAV, adeno-associated virus, 0302 clinical medicine, Genome editing, 7 NGS, next-generation sequencing, recombinant AAV, Immunology and Allergy, CRISPR, Adeno-associated virus, HDR, homology-directed repair, 0303 health sciences, NP59 capsid, Gastroenterology, humanised FRG mice, rAAV, recombinant adeno-associated virus, 3. Good health, homology-directed repair, U6, RNA polymerase III promoter for human U6 snRNA, 030220 oncology & carcinogenesis, SaCas9, Staphylococcus aureus Cas9 nuclease, CRISPR-Cas9, Research Article, TBG, human thyroxine binding globulin promoter, Ornithine transcarbamylase, Computational biology, Biology, LSP1, liver-specific promoter, Homology directed repair, 03 medical and health sciences, synthetic capsid, PRE, mutant form of the Woodchuck hepatitis virus posttranscriptional regulatory element, InDels, insertions and deletions, PAM, protospacer adjacent motif, Internal Medicine, medicine, genome editing, lcsh:RC799-869, Gene, 030304 developmental biology, Hepatology, OTC deficiency, sgRNA, single guide RNA, WT, wild-type, FRG, Fah-/-Rag2-/-Il2rg, primary human hepatocytes, NHEJ, non-homologous end joining, lcsh:Diseases of the digestive system. Gastroenterology, pA, bovine growth hormone polyadenylation signal sequence, SV40 pA, SV40 polyadenylation signal sequence, Minigene

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db43f1b07a8924ee43c66eaf654d9a6bTest
https://pubmed.ncbi.nlm.nih.gov/32039406Test

المؤلفون: Ronald Chalmers, Michael Tellier

المصدر: DNA Repair

مصطلحات موضوعية: DNA End-Joining Repair, DSB, DNA double-strand break, DNA Repair, DNA repair, Biology, medicine.disease_cause, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Plasmid, Protein Domains, Cell Line, Tumor, Transcriptional regulation, medicine, Humans, DNA Breaks, Double-Stranded, Metnase, DNA Integration, Molecular Biology, Gene, 030304 developmental biology, Genetics, 0303 health sciences, Mutation, SETMAR, DNA double-strand break repair, DNA, Histone-Lysine N-Methyltransferase, Cell Biology, Non-homologous end joining, DNA integration, chemistry, NHEJ, non-homologous end joining, 030220 oncology & carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb42ee4bfe72e379a40f8def4c08a3cTest
http://ora.ox.ac.uk/objects/uuidTest: