Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial
| العنوان: | Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial |
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| المؤلفون: | Soldevila-Domenech, Natalia, Boronat, Anna, Mateus Rodríguez, Julian Andrés, Diaz-Pellicer, Patricia, Matilla, Iris, Pérez-Otero, Marta, Aldea-Perona, Ana, de la Torre, Rafael, Universitat Autònoma de Barcelona |
| المصدر: | Nutrients Volume 11 Issue 9 Nutrients, Vol 11, Iss 9, p 2241 (2019) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Antioxidant, medicine.medical_treatment, Alcohol, Wine, Antioxidants, Cytochrome P-450 CYP2A6, chemistry.chemical_compound, CYP2A6, Biotransformation, Hydroxytyrosol, Food science, polygenic activity score, Nutrition and Dietetics, Cross-Over Studies, Chemistry, alcohol, CYP2D6, food and beverages, Beer, Phenylethyl Alcohol, Cytochrome P-450 CYP2D6, behavior and behavior mechanisms, Female, lcsh:Nutrition. Foods and food supply, hydroxytyrosol, Adult, Genotype, Polygenic activity score, lcsh:TX341-641, Article, 03 medical and health sciences, Young Adult, Tyrosol, medicine, Humans, 030109 nutrition & dietetics, Metabolism, 030104 developmental biology, human activities, metabolism, Food Science, tyrosol |
| الوصف: | Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by CYP2A6 and CYP2D6 polymorphic enzymes. We investigated in humans the rate of this bioconversion after beer and red wine (RW) intake. In a single blind, randomized, crossover, controlled clinical trial (n = 20 healthy subjects), we evaluated TYR absorption and biotransformation into HT following a single dose of (i) RW, (ii) Indian pale ale beer (IPA), (iii) blonde beer, and (iv) non-alcoholic beer (free). Individuals were genotyped for CYP2A6 and CYP2D6, and a polygenic activity score (PAS) was derived. RW triggered the highest increase in total TYR recovered, followed by IPA, blonde, and free beers. Although the HT content in beer was minimal, an increase in HT production was observed in all beers following TYR in a dose-response manner, confirming TYR to HT biotransformation. Sex differences were identified in the rate of the conversion following RW. PAS scores correlated linearly with the recoveries of HT (HT:TYR ratios) after RW intake. In conclusion, after beer and RW consumption, TYR is absorbed and endogenously biotransformed into HT. This mechanism could be modulated by sex, genetics, and matrix components. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e564fc319e399ec3bf8afbf2bb5118d6Test https://pubmed.ncbi.nlm.nih.gov/31540384Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e564fc319e399ec3bf8afbf2bb5118d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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