المؤلفون: Natsumi Amezawa, Yu Kawakatsu, Ikumi Tamai, Hiroshi Arakawa

المصدر: Biological and Pharmaceutical Bulletin. 43:1792-1798

مصطلحات موضوعية: 0301 basic medicine, Purine, Monosaccharide Transport Proteins, Organic Cation Transport Proteins, Pyridines, Xanthine Dehydrogenase, Anion Transport Proteins, Glucose Transport Proteins, Facilitative, Organic Anion Transporters, Pharmaceutical Science, Pharmacology, Xanthine, Madin Darby Canine Kidney Cells, Kidney Tubules, Proximal, Xenopus laevis, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Nitriles, medicine, Animals, Benzothiazoles, Rats, Wistar, Hypoxanthine, Kidney, Reabsorption, General Medicine, Recombinant Proteins, Rats, Uric Acid, Renal Elimination, Topiroxostat, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Paracellular transport, Models, Animal, Oocytes, Uric acid, Reactive Oxygen Species

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b538210229ce59762e199b1fc0d51d73Test
https://doi.org/10.1248/bpb.b20-00597Test

المؤلفون: Yusuke Masuo, Hiroshi Arakawa, Yukio Kato, Noritaka Nakamichi, Takumi Kawanishi

المصدر: Journal of Pharmaceutical Sciences. 108:3130-3137

مصطلحات موضوعية: Male, ATP Binding Cassette Transporter, Subfamily B, medicine.drug_class, Administration, Oral, Pharmaceutical Science, 02 engineering and technology, Pharmacology, digestive system, 030226 pharmacology & pharmacy, Intestinal absorption, Tyrosine-kinase inhibitor, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Oral administration, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, Intestinal Mucosa, Cholestasis, Intestinal permeability, Microvilli, Chemistry, Bile duct, Cell Membrane, Imatinib, 021001 nanoscience & nanotechnology, medicine.disease, Up-Regulation, Disease Models, Animal, medicine.anatomical_structure, Intestinal Absorption, Imatinib Mesylate, Administration, Intravenous, 0210 nano-technology, Tyrosine kinase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4379142fc0d1120bf3cd16514e184426Test
https://doi.org/10.1016/j.xphs.2019.05.017Test

المؤلفون: Ikumi Tamai, Shiho Nedachi, Ikumi Washio, Naoki Ishiguro, Takeo Nakanishi, Angelina Yukiko Staub, Hiroshi Arakawa, Hikaru Kubo

المصدر: Journal of Pharmaceutical Sciences. 108:2798-2804

مصطلحات موضوعية: Male, ATP Binding Cassette Transporter, Subfamily B, Organic Cation Transport Proteins, Pharmaceutical Science, 02 engineering and technology, Pharmacology, Kidney, Peptide Transporter 1, 030226 pharmacology & pharmacy, Kidney Tubules, Proximal, 03 medical and health sciences, chemistry.chemical_compound, Sodium-Glucose Transporter 1, 0302 clinical medicine, medicine, Animals, Humans, Pharmacokinetics, Carnitine, Rats, Wistar, Zosuquidar, Symporters, Reabsorption, Biological Transport, Transporter, Apical membrane, 021001 nanoscience & nanotechnology, Rats, HEK293 Cells, medicine.anatomical_structure, Pharmaceutical Preparations, chemistry, Ergothioneine, Efflux, 0210 nano-technology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773f701e332e9832876352ae3b400ed3Test
https://doi.org/10.1016/j.xphs.2019.03.031Test

المؤلفون: Yusuke Kato, Marie Shinohara, Yukio Kato, Tomoki Nakatsuji, Manami Mitsuta, Yuuichi Oda, Takumi Kawanishi, Sylvia Leo, Keita Iino, Hiroshi Arakawa, Hiroshi Kimura, Wataru Nihei, Kenta Shinha, Shoen Kume, Tomomi Goto, Takumi Nishiuchi, Toshiyuki Kanamori, Kosuke Inamura, Nobuaki Shiraki, Masaki Nishikawa, Taku Satoh, Karin Araya, Shinji Sugiura, Kikuo Komori, Yasuyuki Sakai

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Science, Induced Pluripotent Stem Cells, Drug Evaluation, Preclinical, 02 engineering and technology, Article, Mice, 03 medical and health sciences, Downregulation and upregulation, In vivo, Lab-On-A-Chip Devices, Pressure, Animals, Humans, Gene, media_common, Multidisciplinary, Chemistry, Biological techniques, Albumin, Metabolism, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, Coculture Techniques, In vitro, Cell biology, Human hepatocyte, 030104 developmental biology, Hepatocytes, Medicine, 0210 nano-technology, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e97fbbe5db5cadc517099519d2d84fTest
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100856406Test

المؤلفون: Takako Kato, Fumiyoshi Kasahara, Yoko Idota, Takuo Ogihara, Chihiro Miyajima, Hiroshi Arakawa, Hitoe Takahashi, Chihaya Kakinuma, Kurt Hara, Kentaro Yano

المصدر: Biological and Pharmaceutical Bulletin. 42:365-372

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Calcium alginate, Alginates, Pharmaceutical Science, Absorption (skin), Diet, High-Fat, Excretion, Feces, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Animals, Lipase, Triglycerides, Alginic acid, Pharmacology, Dose-Response Relationship, Drug, Triglyceride, biology, Chemistry, Body Weight, Lipid metabolism, General Medicine, Lipid Metabolism, Rats, 030104 developmental biology, Endocrinology, Adipose Tissue, Liver, 030220 oncology & carcinogenesis, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a2c81329485025678e94480e9c1644Test
https://doi.org/10.1248/bpb.b18-00530Test

المؤلفون: Yukio Kato, Hiroyuki Kusuhara, Françoise Gilard, Johanna Bruce, Daiki Mori, Marjorie Leduc, Hiroshi Arakawa, Atsushi Miyajima, Stéphane Poulain, Karin Araya, Taketomo Kido, Mathieu Danoy, Morgane Le Gall, Charles Plessy, Eric Leclerc, Rachid Jellali, Yasuyuki Sakai, Yannick Tauran

المساهمون: Laboratory for Integrated Micro Mechatronics Systems (LIMMS), The University of Tokyo (UTokyo)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo (UTokyo), Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), RIKEN Center for Life Science Technologies (RIKEN CLST), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Plateforme protéomique 3P5 [Institut Cochin] (3P5), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Kanazawa University (KU), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science 16H06328, ANR-16-RHUS-0005,iLite,iLite(2016), JELLALI, RACHID, iLite - - iLite2016 - ANR-16-RHUS-0005 - RHUS - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

المصدر: Biotechnology and Bioengineering
Biotechnology and Bioengineering, In press, ⟨10.1002/bit.27667⟩
Biotechnology and Bioengineering, Wiley, In press, ⟨10.1002/bit.27667⟩

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Induced Pluripotent Stem Cells, iPSCs, Bioengineering, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Biology, Proteomics, liver, 01 natural sciences, Applied Microbiology and Biotechnology, Transcriptome, 03 medical and health sciences, transcriptomics, Metabolomics, proteomics, 010608 biotechnology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Humans, Induced pluripotent stem cell, Biochip, Regeneration (biology), nanoCAGE, Cell Differentiation, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Genomics, differentiation, metabolomics, Liver regeneration, In vitro, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Liver Regeneration, Cell biology, 030104 developmental biology, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], hepatocytes, organ-on-chip, Biotechnology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023a1891bdf8ee3512105731f3d198c4Test
https://hal.utc.fr/hal-03288795/documentTest

المؤلفون: Hiroki Morishita, Kozue Okawa, Kentaro Yano, Kenta Mizoi, Takuo Ogihara, Misaki Ishii, Hiroshi Arakawa, Masaaki Ito

المصدر: PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0232438 (2020)

مصطلحات موضوعية: Side effect, Swine, Science, Aripiprazole, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pimozide, Sertraline, medicine, Animals, Humans, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, Gastrointestinal tract, Multidisciplinary, biology, Chemistry, Biological Transport, Gastrointestinal Absorption, biology.protein, Medicine, LLC-PK1 Cells, Efflux, Caco-2 Cells, 030217 neurology & neurosurgery, Drug metabolism, medicine.drug, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d5183a21cdd62f59f9796a2915ca8eTest
http://europepmc.org/articles/PMC7595425Test

المؤلفون: Yuichi Torisu, Masayuki Kato, Kazuki Sumiyama, Masanori Nakano, Kazuki Takakura, Keisuke Kanazawa, Shintaro Tsukinaga, Yosuke Kawahara, Yuji Kinoshita, Hirobumi Toyoizumi, Nana Shimamoto, Hiroshi Arakawa, Seita Koyama, Keiichi Ikeda, Youichi Tomita, Takahiro Abe, Masafumi Chiba

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Self Expandable Metallic Stents, lcsh:Medicine, Risk Assessment, Article, Bile duct cancer, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Self-expandable metallic stent, Interquartile range, Biliary tract disease, Pancreatic cancer, Humans, Medicine, Pancreatic disease, lcsh:Science, Gastrointestinal diseases, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, Multidisciplinary, business.industry, lcsh:R, Stent, Middle Aged, medicine.disease, Surgery, Biliary Tract Neoplasms, 030104 developmental biology, Quartile, Multivariate Analysis, Feasibility Studies, Regression Analysis, Female, lcsh:Q, business, Plastics, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf52c21b3bce3ab21819fbe3d2b7f06Test
https://doi.org/10.1038/s41598-020-70081-3Test

المؤلفون: Hiroshi Arakawa, Hiroyuki Kusuhara, Yukio Kato, Eric Leclerc, Mathieu Danoy, Karin Araya, Yasuyuki Sakai, Charles Plessy, Taketomo Kido, Yannick Tauran, Stéphane Poulain, Sachi Kato, Atsushi Miyajima, Daiki Mori

المساهمون: Laboratory for Integrated Micro Mechatronics Systems (LIMMS), The University of Tokyo (UTokyo)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de Ressources Biologiques - [Nancy] (CRB Nancy), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), RIKEN Center for Life Science Technologies (RIKEN CLST), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), The University of Tokyo (UTokyo), Laboratory of Pharmacokinetics, Kanazawa University (KU), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Biomécanique et génie biomédical (BIM), Centre National de la Recherche Scientifique (CNRS)

المصدر: Differentiation
Differentiation, Elsevier, 2020, 114, pp.36-48. ⟨10.1016/j.diff.2020.05.006⟩

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Epithelial-Mesenchymal Transition, [SDV]Life Sciences [q-bio], Induced Pluripotent Stem Cells, Drug Evaluation, Preclinical, Oncostatin M, Biology, Transcriptome, Cytochrome P-450 CYP2C8, 03 medical and health sciences, 0302 clinical medicine, Cytochrome P-450 CYP1A2, medicine, Cytochrome P-450 CYP3A, Humans, NRF1, Induced pluripotent stem cell, Molecular Biology, Transcription factor, ComputingMilieux_MISCELLANEOUS, Cell Proliferation, Nuclear Respiratory Factor 1, Liver cell, Cell Differentiation, Cell Biology, Liver regeneration, 3. Good health, HNF1A, Cell biology, Liver Regeneration, Cytochrome P-450 CYP2B6, 030104 developmental biology, medicine.anatomical_structure, Sp3 Transcription Factor, Cytochrome P-450 CYP2D6, Liver, Hepatocyte, Hepatocytes, 030217 neurology & neurosurgery, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8899b305bcd2553191fab92d8eea1680Test
https://hal.archives-ouvertes.fr/hal-02884044Test

المؤلفون: Kyoko Ondo, Miki Nakajima, Masataka Nakano, Hiroshi Arakawa, Tatsuki Fukami

المصدر: Biochemical pharmacology. 175

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Monosaccharide Transport Proteins, Glucuronidation, Endoplasmic Reticulum, digestive system, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Glucuronides, Humans, Glucuronosyltransferase, Pharmacology, Gene knockdown, Chemistry, Endoplasmic reticulum, HEK 293 cells, Transporter, Molecular biology, Glucuronosyltransferase activity, 030104 developmental biology, HEK293 Cells, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Microsome, Hepatocytes, Uridine Diphosphate Glucuronic Acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3028a8440d0bed4880f16d4b1c61e1Test
https://pubmed.ncbi.nlm.nih.gov/32179043Test