نتائج البحث

1

The F-box protein, FBXO7, is required to maintain chromosome stability in humans

المؤلفون: Ally C. Farrell, Zelda Lichtensztejn, Kirk J. McManus, Michaela C. L. Palmer, Tooba Razi, Nicole M. Neudorf

المصدر: Human Molecular Genetics. 31:1471-1486

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7109d3d5c667b6a8d37d6f46b59e5f0fTest
https://doi.org/10.1093/hmg/ddab330Test

2

Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes

المؤلفون: Xin-Ping Zhao, Isabelle Chenier, John S.D. Chan, Shao-Ling Zhang, Julie R. Ingelfinger, Michifumi Yamashita, Shuiling Zhao, Chao-Sheng Lo, Janos G. Filep, Kana N. Miyata

المصدر: Diabetologia

مصطلحات موضوعية: Blood Glucose, Male, Glycosuria, endocrine system, medicine.medical_specialty, endocrine system diseases, Increased glomerular filtration rate, Endocrinology, Diabetes and Metabolism, Blotting, Western, Angiotensinogen, Heterogeneous nuclear ribonucleoprotein F, Down-Regulation, Renal function, Blood Pressure, 030204 cardiovascular system & hematology, Real-Time Polymerase Chain Reaction, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Sodium-Glucose Transporter 2, Theophylline, Downregulation and upregulation, Internal medicine, Internal Medicine, medicine, Animals, 030304 developmental biology, Tubuloglomerular feedback, Mice, Knockout, 0303 health sciences, Heterogeneous-Nuclear Ribonucleoprotein Group F-H, business.industry, Acute Kidney Injury, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, Diabetes Mellitus, Type 1, Kidney Tubules, Endocrinology, Purinergic P1 Receptor Antagonists, Albuminuria, medicine.symptom, business, hormones, hormone substitutes, and hormone antagonists, Glomerular hyperfiltration, Glomerular Filtration Rate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22e0691c4274bf48b5e06be79b4e842Test
https://doi.org/10.1007/s00125-021-05538-9Test

3

Halogenation at the Phenylalanine Residue of Monomethyl Auristatin F Leads to a Favorable cis/trans Equilibrium and Retained Cytotoxicity

المؤلفون: Mirkka Sarparanta, Surachet Imlimthan, Iris Katariina Sokka, Filip S. Ekholm, Mikael P. Johansson, Hannu Maaheimo

المساهمون: Department of Chemistry, Doctoral Programme in Chemistry and Molecular Sciences, Helsinki Institute of Sustainability Science (HELSUS)

المصدر: Sokka, I K, Imlimthan, S, Sarparanta, M, Maaheimo, H, Johansson, M P & Ekholm, F S 2021, ' Halogenation at the phenylalanine residue of monomethyl auristatin f leads to a favorable cis/ trans equilibrium and retained cytotoxicity ', Molecular Pharmaceutics, vol. 18, no. 8, pp. 3125-3131 . https://doi.org/10.1021/acs.molpharmaceut.1c00342Test
Molecular Pharmaceutics

مصطلحات موضوعية: LINKER, Immunoconjugates, Magnetic Resonance Spectroscopy, Halogenation, Molecular Conformation, Pharmaceutical Science, auristatins, Mice, 0302 clinical medicine, NMR-spectroscopy, Neoplasms, Drug Discovery, Aminobenzoates, Antibody-drug conjugates, DRUG, Cytotoxicity, Auristatins, 0303 health sciences, Cytotoxins, Chemistry, Biological activity, Nuclear magnetic resonance spectroscopy, Structural characterization, Nmr-spectroscopy, Monomethyl auristatin F, 317 Pharmacy, 030220 oncology & carcinogenesis, Molecular Medicine, Cancer therapeutics, Oligopeptides, antibody−drug conjugates, medicine.drug, Cell Survival, Phenylalanine, antibody-drug conjugates, Antineoplastic Agents, Article, cancer therapeutics, 03 medical and health sciences, Isomerism, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Animals, Humans, VEDOTIN, 030304 developmental biology, Combinatorial chemistry, NMR, structural characterization, PET, ANTIBODY, DISCOVERY, DOLASTATIN-10, Linker, Cis–trans isomerism, Conjugate