المؤلفون: Henk M.W. Verheul, Tanja D. de Gruijl, Marco B. Polee, Paul Hamberg, Charlotte M. Huijts, Maartje Los, Inge M. Werter, Sinéad. M. Lougheed, Hans van Vliet, John B. A. G. Haanen, Helgi H. Helgason, Metin Tascilar

المساهمون: Internal medicine, Medical oncology, CCA - Cancer biology and immunology, AII - Cancer immunology, Medical oncology laboratory, Academic Medical Center

المصدر: Werter, I M, Huijts, C M, Lougheed, S M, Hamberg, P, Polee, M B, Tascilar, M, Los, M, Haanen, J B A G, Helgason, H H, Verheul, H M, de Gruijl, T D, van der Vliet, H J & Dutch WIN-O Consortium 2019, ' Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus ', Cancer Immunology, Immunotherapy, vol. 68, no. 5, pp. 787-798 . https://doi.org/10.1007/s00262-019-02313-zTest
Cancer Immunology, Immunotherapy, 68(5), 787-798. Springer Science and Business Media Deutschland GmbH
Cancer Immunology Immunotherapy, 68, 5, pp. 787-798
Cancer immunology, immunotherapy, 68(5), 787-798. Springer Science and Business Media Deutschland GmbH
Cancer Immunology Immunotherapy, 68, 787-798

مصطلحات موضوعية: Oncology, Male, Cancer Research, Renal Cell/drug therapy, Everolimus/therapeutic use, T-Lymphocytes, Phases of clinical research, TOR Serine-Threonine Kinases/metabolism, T-Lymphocytes, Regulatory, Tyrosine-kinase inhibitor, chemistry.chemical_compound, Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2], 0302 clinical medicine, Immunology and Allergy, Medicine, TOR Serine-Threonine Kinases, Middle Aged, Kidney Neoplasms, Vascular endothelial growth factor, Kidney Neoplasms/drug therapy, Treatment Outcome, Cyclophosphamide/therapeutic use, Female, Immunosuppressive Agents, medicine.drug, medicine.medical_specialty, Cyclophosphamide, medicine.drug_class, Immunology, T-Lymphocytes, Regulatory/immunology, 03 medical and health sciences, Immune system, Internal medicine, Humans, Everolimus, Carcinoma, Renal Cell, PI3K/AKT/mTOR pathway, Aged, Cell Proliferation, business.industry, Carcinoma, Interim analysis, Survival Analysis, chemistry, Carcinoma, Renal Cell/drug therapy, Immunosuppressive Agents/therapeutic use, Regulatory/immunology, business, 030215 immunology, Follow-Up Studies

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b177ecb737553601b0a3e3e00e7159Test
https://pubmed.ncbi.nlm.nih.gov/30756132Test

المؤلفون: Ludmila Prudkin, José Baselga, Amelia Barnett, Leire Arreal, María L. Martínez-Chantar, Alejo Efeyan, Arkaitz Carracedo, Elena Castro, Violeta Serra, Yinan Zhang, David Pirman, Ylenia Cendon, Teresa Macarulla, Patricia Zúñiga-García, Rosa Farràs, José M. Mato, Rosa Barrio, Inés Cristina Torres, Julen Tomás-Cortázar, Juan Anguita, Juan M. Falcón-Pérez, Alfredo Caro-Maldonado, Gina Lein, Josep Tabernero, Ana Loizaga-Iriarte, Amaia Zabala-Letona, James D. Sutherland, Jose Jimenez, David Olmos, Mikel Azkargorta, Naiara Beraza, Carlos Cordon-Cardo, Pilar Sanchez-Mosquera, Ajinkya Revandkar, Paolo Nuciforo, Felix Elortza, Ruzica Bago, Isabel Lacasa-Viscasillas, Stuart Murray, Miguel Unda, Natalia Martín-Martín, Verónica Torrano, Mireia Castillo-Martin, Ana M. Aransay, Itziar Fernández-Domínguez, Antonio Gentilella, Sebastiaan M. Van Liempd, Brendan D. Manning, Aitziber Ugalde-Olano, Pilar Ximénez-Embún, Andrea Alimonti, Lorea Valcarcel-Jimenez, Javier Muñoz, Sonia Fernández-Ruiz, Diana Cabrera, Amaia Arruabarrena-Aristorena, Michelle Clasquin, Katya Marjon, Phong Quang, Marco Piva, Ana R. Cortazar, George Thomas, Kevin R Marks, Ianire Astobiza

المصدر: NATURE
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Nature, vol. 547, no. 7661, pp. 109-113
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
Nature
Dipòsit Digital de la UB
Universidad de Barcelona

مصطلحات موضوعية: 0301 basic medicine, Male, Adenosylmethionine Decarboxylase, S-Adenosylmethionine, mTORC1, Biology, Oncogenicity, Mechanistic Target of Rapamycin Complex 1, Article, 03 medical and health sciences, chemistry.chemical_compound, Prostate cancer, Mice, Phosphatidylinositol 3-Kinases, Downregulation and upregulation, Protein kinases, Neoplasms, medicine, Polyamines, Animals, Humans, Metabolomics, Everolimus, Cell Proliferation, Multidisciplinary, Càncer de pròstata, Cell growth, Protein Stability, TOR Serine-Threonine Kinases, PTEN Phosphohydrolase, Cancer, Prostatic Neoplasms, Adenosylmethionine Decarboxylase/immunology, Adenosylmethionine Decarboxylase/metabolism, Enzyme Activation, Everolimus/therapeutic use, Multiprotein Complexes/antagonists & inhibitors, Multiprotein Complexes/metabolism, PTEN Phosphohydrolase/metabolism, Phosphatidylinositol 3-Kinases/metabolism, Polyamines/metabolism, Prostatic Neoplasms/drug therapy, Prostatic Neoplasms/metabolism, Prostatic Neoplasms/pathology, S-Adenosylmethionine/analogs & derivatives, S-Adenosylmethionine/metabolism, TOR Serine-Threonine Kinases/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism, medicine.disease, 3. Good health, Proteïnes quinases, 030104 developmental biology, chemistry, Biochemistry, Multiprotein Complexes, Cancer cell, Cancer research, biological phenomena, cell phenomena, and immunity, Polyamine, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c46ce2fd07391467ea991e3f352e43cTest
https://ddd.uab.cat/pub/artpub/2017/pmc_28658205/pmc_28658205.pdfTest