BAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression
| العنوان: | BAP31, a newly defined cancer/testis antigen, regulates proliferation, migration, and invasion to promote cervical cancer progression |
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| المؤلفون: | Yuanjie Sun, Boquan Jin, Chunmei Zhang, Liang Tao, Jian Wang, Dongbo Jiang, Erle Dang, Wei Fan, Jing Wang, Zichao Li, Kun Yang, Shuya Yang, Tingting Liu, Chao-jun Song |
| المصدر: | Cell Death and Disease, Vol 9, Iss 8, Pp 1-15 (2018) Cell Death & Disease |
| بيانات النشر: | Nature Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cancer Research, Somatic cell, Immunology, Mice, Nude, Uterine Cervical Neoplasms, Kaplan-Meier Estimate, Biology, Article, Metastasis, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cell Movement, Cell Line, Tumor, Testis, medicine, Animals, Humans, RNA, Small Interfering, lcsh:QH573-671, Cell Proliferation, Cervical cancer, Cell growth, lcsh:Cytology, Liver Neoplasms, Neuropeptides, Ovary, Membrane Proteins, Cancer, Cell Biology, Cell cycle, medicine.disease, G1 Phase Cell Cycle Checkpoints, 030104 developmental biology, Monoclonal, Disease Progression, Cancer research, Cancer/testis antigens, Female, RNA Interference |
| الوصف: | Malignant tumors typically undergo an atavistic regression characterized by the overexpression of embryonic genes and proto-oncogenes, including a variety of cancer/testis antigens (CTAs) that are testis-derived and are not expressed or expressed in trace amounts in somatic tissues. Based on this theory, we established a new method to identify unknown CTAs, the spermatogenic cells-specific monoclonal antibody-defined cancer/testis antigen (SADA) method. Using the SADA method, we identified BAP31 as a novel CTA and confirmed that BAP31 expression is associated with progression and metastasis of several cancers, particularly in cervical cancer. We found that BAP31 was significantly upregulated in stage I, II, and III cervical cancer patients and highly correlated with poor clinic outcomes. We further demonstrated that BAP31 regulates cervical cancer cell proliferation by arresting the cell cycle at the G0/G1 stage and that depletion of BAP31 inhibits hyper-proliferation. Moreover, depletion of BAP31 inhibits cervical cancer cell invasion and migration by regulating the expression and subcellular localization of Drebrin, M-RIP, SPECC1L, and Nexilin, and then affect the cytoskeleton assemblage. Finally, the depletion of BAP31 prevents cervical cancer progression and metastasis in vivo. These findings provide a new method for identifying novel CTAs as well as mechanistic insights into how BAP31 regulates cervical cancer hyper-proliferation and metastasis. |
| اللغة: | English |
| تدمد: | 2041-4889 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa18066b0b1689866e67d8b1fa3a0feTest http://link.springer.com/article/10.1038/s41419-018-0824-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....baa18066b0b1689866e67d8b1fa3a0fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20414889 |
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