Improving clinical paediatric research and learning from COVID-19: recommendations by the Conect4Children expert advice group
| العنوان: | Improving clinical paediatric research and learning from COVID-19: recommendations by the Conect4Children expert advice group |
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| المؤلفون: | Ramanan, Athimalaipet V., Modi, Neena, de Wildt, Saskia N., Aurich, Beate, Bakhtadze, Sophia, Sirvent, Francisco J. Bautista, Cabañas, Fernando, Campbell, Lisa, Casanova, Michaela, Charlton, Philippa, Crandall, Wallace, Eichler, Irmgard, Fregonese, Laura, Hawcutt, Daniel B., Iveli, Pablo, Jaki, Thomas, Jocic-Jakubi, Bosanka, Johnson, Mats, Kaguelidou, Florentina, Karadag, Bülent, Kelly, Lauren E., Lim, Ming, Moreno, Carmen, Neumann, Eva, Ollivier, Cécile, Oualha, Mehdi, Raffaeli, Genny, Ribeiro, Maria A., Roilides, Emmanuel, de Rojas, Teresa, Simón, Alba Rubio San, Ruperto, Nicolino, Scarpa, Maurizio, Schwab, Matthias, Siapkara, Angeliki, Singh, Yogen, Smits, Anne, Striano, Pasquale, Urru, Silvana A. M., Vivarelli, Marina, de Wildt, Saskia, Zivkoviz, Zorica |
| المساهمون: | Pediatric Surgery, Ramanan A. V. , Modi N., de Wildt S. N. , Aurich B., Bakhtadze S., Sirvent F. J. B. , Cabañas F., Campbell L., Casanova M., Charlton P., et al. |
| المصدر: | Pediatric Research Pediatric research Pediatric Research, 91, 1069-1077 Pediatric Research, 91, 5, pp. 1069-1077 CORE (RIOXX-UK Aggregator) PubMed Central ORCID Microsoft Academic Graph OpenAIRE Pediatric Research, 91(5), 1069-1077. Lippincott Williams & Wilkins |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Expert advice, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, Sağlık Bilimleri, Pediatrics, Clinical Medicine (MED), Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases, Special Article, 03 medical and health sciences, 0302 clinical medicine, Health Sciences, Health care, Humans, Klinik Tıp (MED), 030212 general & internal medicine, Pediatrics, Perinatology, and Child Health, Pediatri, Perinatoloji ve Çocuk Sağlığı, Child, Pandemics, Internal Medicine Sciences, Klinik Tıp, business.industry, Research, COVID-19, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Public relations, Tıp, 3. Good health, Europe, Clinical research, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Medicine, PEDİATRİ, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business |
| الوصف: | Background The COVID-19 pandemic has had a devastating impact on multiple aspects of healthcare, but has also triggered new ways of working, stimulated novel approaches in clinical research and reinforced the value of previous innovations. Conect4children (c4c, www.conect4children.org) is a large collaborative European network to facilitate the development of new medicines for paediatric populations, and is made up of 35 academic and 10 industry partners from 20 European countries, more than 50 third parties, and around 500 affiliated partners. Methods We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equity. Findings We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equityWe provide examples of research innovation, and follow this with recommendations to improve the efficiency of future trials, drawing on industry perspectives, regulatory considerations, infrastructure requirements and parent–patient–public involvement. We end with a comment on progress made towards greater international harmonisation of paediatric research and how lessons learned from COVID-19 studies might assist in further improvements in this important area. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1530-0447 0031-3998 |
| DOI: | 10.1038/s41390-021-01587-3 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b66934452d4194eab14fdeb325f7d9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....51b66934452d4194eab14fdeb325f7d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15300447 00313998 |
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| DOI: | 10.1038/s41390-021-01587-3 |