نتائج البحث - "Agostina Nardone"

1

Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer

المساهمون: De Angelis, C., Fu, X., Cataldo, M. L., Nardone, A., Pereira, R., Veeraraghavan, J., Nanda, S., Qin, L., Sethunath, V., Wang, T., Hilsenbeck, S. G., Benelli, M., Migliaccio, I., Guarducci, C., Malorni, L., Litchfield, L. M., Liu, J., Donaldson, J., Selenica, P., Brown, D. N., Weigelt, B., Reis-Filho, J. S., Park, B. H., Hurvitz, S. A., Slamon, D. J., Rimawi, M. F., Jansen, V. M., Jeselsohn, R., Osborne, C. K., Schiff, R.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 17

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Pyridines, Oncology and Carcinogenesis, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Palbociclib, Piperazines, 03 medical and health sciences, 0302 clinical medicine, Immune system, Breast cancer, Receptors, Breast Cancer, Genetics, Tumor Cells, Cultured, Humans, Medicine, Oncology & Carcinogenesis, Cancer, Cultured, biology, business.industry, Kinase, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, medicine.disease, Estrogen, Immune checkpoint, Tumor Cells, Good Health and Well Being, 030104 developmental biology, Receptors, Estrogen, Oncology, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Female, Cyclin-dependent kinase 6, Development of treatments and therapeutic interventions, Signal transduction, business, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8d5dea84c01cc54303c5f5ebf7c4dcTest
https://doi.org/10.1158/1078-0432.ccr-19-4191Test

2

Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer

المساهمون: Sethunath, Vidyalakshmi, Hu, Huizhong, DE ANGELIS, Carmine, Veeraraghavan, Jamunarani, Qin, Lanfang, Wang, Nichola, Simon, Lukas M, Wang, Tao, Fu, Xiaoyong, Nardone, Agostina, Pereira, Resel, Nanda, Sarmistha, Griffith, Obi L, Tsimelzon, Anna, Shaw, Chad, Chamness, Gary C, Reis-Filho, Jorge S, Weigelt, Britta, Heiser, Laura M, Hilsenbeck, Susan G, Huang, Shixia, Rimawi, Mothaffar F, Gray, Joe W, Osborne, C Kent, Schiff, Rachel

المصدر: Mol Cancer Res
Mol. Cancer Res. 17, 2318-2330 (2019)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Geranylgeranyl pyrophosphate, Receptor, ErbB-2, Farnesyl pyrophosphate, Mevalonic Acid, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Mechanistic Target of Rapamycin Complex 1, Lapatinib, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Survivin, Humans, Medicine, Phosphorylation, skin and connective tissue diseases, neoplasms, Molecular Biology, business.industry, Cell growth, Trastuzumab, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, Female, Mevalonate pathway, Growth inhibition, business, Signal Transduction, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47e32d952d195af7dec86930048dfc3Test
https://doi.org/10.1158/1541-7786.mcr-19-0756Test

3

The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance

المؤلفون: Agostina Nardone, Rachel Schiff, Henry Brown, Meghana V. Trivedi, Martin Shea, Mark Pilling, Jamunarani Veeraraghavan, Chandandeep Nagi, Rinath Jeselsohn, Carmine De Angelis, Oona Delpuech, Maria Letizia Cataldo, Tamika Mitchell, C. Kent Osborne, Mothaffar F. Rimawi, Hazel M. Weir, Gary C. Chamness, Xiaoyong Fu, Susan G. Hilsenbeck

المساهمون: Pilling, Mark [0000-0002-7446-6597], Apollo - University of Cambridge Repository, Nardone, A., Weir, H., Delpuech, O., Brown, H., De Angelis, C., Cataldo, M. L., Fu, X., Shea, M. J., Mitchell, T., Veeraraghavan, J., Nagi, C., Pilling, M., Rimawi, M. F., Trivedi, M., Hilsenbeck, S. G., Chamness, G. C., Jeselsohn, R., Osborne, C. K., Schiff, R.

المصدر: British Journal of Cancer

مصطلحات موضوعية: Cancer Research, Indoles, Neoplasms, Hormone-Dependent, Breast Neoplasms, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, MCF-7 Cell, 0302 clinical medicine, Breast cancer, Cinnamate, In vivo, medicine, Animals, Humans, Receptor, skin and connective tissue diseases, Fulvestrant, Cancer, Cell Proliferation, Estradiol, Animal, Cell growth, Estrogens, medicine.disease, Estrogen, Metastatic breast cancer, 3. Good health, Tamoxifen, Oncology, chemistry, Receptors, Estrogen, Indole, Cell culture, Cinnamates, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, MCF-7 Cells, Heterografts, Female, Growth inhibition, Heterograft, Breast Neoplasm, Human, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1307add3c66d5075ec69b579adb4aedTest
http://europepmc.org/articles/PMC6353941Test

4

Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity

المؤلفون: Xiaoyong Fu, Radhika D. Dandekar, Maureen G. Mancini, Rachel Schiff, Suzanne A. W. Fuqua, Guowei Gu, Carmine De Angelis, Agostina Nardone, Fabio Stossi, Clifford Stephan, Hans E. Johansson, Mark T. Bedford, Michael A. Mancini, Wei Xu

المساهمون: Stossi, Fabio, D Dandekar, Radhika, G Mancini, Maureen, Gu, Guowei, W Fuqua, Suzanne A, Nardone, Agostina, DE ANGELIS, Carmine, Fu, Xiaoyong, Schiff, Rachel, T Bedford, Mark, Xu, Wei, E Johansson, Han, C Stephan, Clifford, A Mancini, Michael

المصدر: Nucleic Acids Research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7ce7b2aa4beefcace2eb49798c5df5Test
https://hdl.handle.net/11588/891821Test

5

A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer

المساهمون: Thangavel, Hariprasad, De Angelis, Carmine, Vasaikar, Suha, Bhat, Raksha, Jolly, Mohit Kumar, Nagi, Chandandeep, Creighton, Chad J, Chen, Fengju, Dobrolecki, Lacey E, George, Jason T, Kumar, Tanya, Abdulkareem, Noor Mazin, Mao, Sufeng, Nardone, Agostina, Rimawi, Mothaffar, Osborne, C Kent, Lewis, Michael T, Levine, Herbert, Zhang, Bing, Schiff, Rachel, Giuliano, Mario, Trivedi, Meghana V

المصدر: Journal of Clinical Medicine
Volume 8
Issue 11
Journal of Clinical Medicine, Vol 8, Iss 11, p 1772 (2019)

مصطلحات موضوعية: False discovery rate, RPPA, patient-derived xenograft, lcsh:Medicine, circulating tumor cells, circulating tumor cell, Article, Transcriptome, CTC cluster, 03 medical and health sciences, transcriptomics, 0302 clinical medicine, Circulating tumor cell, Breast cancer, Centre for Biosystems Science and Engineering, medicine, B-cell lymphoma 2, Triple-negative breast cancer, 030304 developmental biology, 0303 health sciences, business.industry, lcsh:R, apoptosis, General Medicine, transcriptomic, Gene signature, medicine.disease, apoptosi, 3. Good health, Lymphoma, 030220 oncology & carcinogenesis, Cancer research, triple-negative breast cancer, Immunohistochemistry, CTC clusters, business

وصف الملف: application/pdf; application/zip

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79d31cd7705c3a50e6d75fb9541f82dTest

6

Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis

المؤلفون: Chandandeep Nagi, Hariprasad Thangavel, Mario Giuliano, Lacey E. Dobrolecki, Agostina Nardone, Carmine De Angelis, Meghana V. Trivedi, Michael T. Lewis, Rachel Schiff, Jackie L. Stilwell, C. Kent Osborne, Debashish Sahay, Sina Hedayatpour, Raksha Bhat, Eric P. Kaldjian, Mothaffar F. Rimawi, Arturo Ramirez

المساهمون: Ramirez, A. B., Bhat, R., Sahay, D., De Angelis, C., Thangavel, H., Hedayatpour, S., Dobrolecki, L. E., Nardone, A., Giuliano, M., KHALIL RODRIGUEZ, Nagi, Rimawi, M., Osborne, C. K., Lewis, M. T., Stilwell, J. L., Kaldjian, E. P., Schiff, R., Trivedi, M. V.

المصدر: BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Cell Separation, Mice, SCID, Metastasis, Antineoplastic Agent, Mice, 0302 clinical medicine, Circulating tumor cell, Breast cancer, Single-cell analysis, Class I Phosphatidylinositol 3-Kinase, medicine.diagnostic_test, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Neoplastic Cells, Circulating, 3. Good health, Patient-derived xenografts, Oncology, 030220 oncology & carcinogenesis, Single-cell analysi, Immunohistochemistry, Keratins, Female, Single-Cell Analysis, Breast Neoplasm, Research Article, Human, Class I Phosphatidylinositol 3-Kinases, Antineoplastic Agents, Breast Neoplasms, Immunofluorescence, lcsh:RC254-282, 03 medical and health sciences, Patient-derived xenograft, Cell Line, Tumor, Genetics, medicine, Biomarkers, Tumor, Animals, Humans, Chemotherapy, Cluster of differentiation, business.industry, Animal, Circulating tumor cells, Leukocyte Common Antigen, Sequence Analysis, DNA, medicine.disease, 030104 developmental biology, Keratin, Cancer cell, Mutation, Cancer research, Leukocyte Common Antigens, business, Neoplasm Transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688296ce56fe9a1f54200af1da1bcffeTest
http://hdl.handle.net/11588/771300Test

7

Abstract GS2-01: High levels of interferon-response gene signatures are associated with de novo and acquired resistance to CDK4/6 inhibitors in ER+ breast cancer

المصدر: Cancer Research. 80:GS2-01

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::62707dc1c64c8977590881b9cb8aac63Test
https://doi.org/10.1158/1538-7445.sabcs19-gs2-01Test

8

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

المساهمون: Xu, X., De Angelis, C., Burke, K. A., Nardone, A., Hu, H., Qin, L., Veeraraghavan, J., Sethunath, V., Heiser, L. M., Wang, N., Ng, C. K. Y., Chen, E. S., Renwick, A., Wang, T., Nanda, S., Shea, M., Mitchell, T., Rajendran, M., Waters, I., Zabransky, D. J., Scott, K. L., Gutierrez, C., Nagi, C., Geyer, F. C., Chamness, G. C., Park, B. H., Shaw, C. A., Hilsenbeck, S. G., Rimawi, M. F., Gray, J. W., Weigelt, B., Reis-Filho, J. S., Osborne, C. K., Schiff, R.

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Xenograft Model Antitumor Assay, Receptor, ErbB-2, Afatinib, medicine.medical_treatment, Breast Neoplasms, Biology, Lapatinib, Antibodies, Monoclonal, Humanized, Article, Targeted therapy, 03 medical and health sciences, Mice, 0302 clinical medicine, Germline mutation, Breast cancer, Trastuzumab, Cell Line, Tumor, medicine, Animals, Humans, Molecular Targeted Therapy, skin and connective tissue diseases, Cell Proliferation, Animal, Cancer, Quinazoline, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Oncology, Receptors, Estrogen, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Immunology, Neratinib, Mutation, Cancer research, Quinazolines, Female, Breast Neoplasm, medicine.drug, Human, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb068280b301594f2965d31acd31789Test
https://europepmc.org/articles/PMC5762201Test/

9

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

المساهمون: Fu, X., Jeselsohn, R., Pereira, R., Hollingsworth, E. F., Creighton, C. J., Li, F., Shea, M., Nardone, A., De Angelis, C., Heiser, L. M., Anur, P., Wang, N., Grasso, C. S., Spellman, P. T., Griffith, O. L., Tsimelzon, A., Gutierrez, C., Huang, S., Edwards, D. P., Trivedi, M. V., Rimawi, M. F., Lopez-Terrada, D., Hilsenbeck, S. G., Gray, J. W., Brown, M., Osborne, C. K., Schiff, R.

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 113(43)

مصطلحات موضوعية: 0301 basic medicine, Hepatocyte Nuclear Factor 3-alpha, Antineoplastic Agents, Hormonal, Prognosi, Estrogen receptor, Breast Neoplasms, Biology, Transcriptome, 03 medical and health sciences, Breast cancer, Cell Line, Tumor, medicine, Humans, RNA, Small Interfering, Gene knockdown, Multidisciplinary, Pioneer factor, Interleukin-8, Estrogen Receptor alpha, medicine.disease, Prognosis, Survival Analysis, Gene Expression Regulation, Neoplastic, Tamoxifen, 030104 developmental biology, PNAS Plus, Drug Resistance, Neoplasm, Transcriptional reprogramming, Cancer research, Female, Survival Analysi, FOXA1, Estrogen receptor alpha, Breast Neoplasm, Endocrine resistance, Human, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2387c3c513051ae7743e2ef46a0318Test
https://pubmed.ncbi.nlm.nih.gov/27791031Test

10

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations

المصدر: Cancer Cell. 33:173-186.e5

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54c4d5a1d642dae3ba71160a090d4f7Test
https://doi.org/10.1016/j.ccell.2018.01.004Test

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