Screening for the presence of scleroedema adultorum of Buschke in patients with diabetes mellitus: newly diagnosed patients had a high prevalence of dyslipidaemia
| العنوان: | Screening for the presence of scleroedema adultorum of Buschke in patients with diabetes mellitus: newly diagnosed patients had a high prevalence of dyslipidaemia |
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| المؤلفون: | Beáta Bódis, Viktória Csonka, Dániel Kovács, Nelli Farkas, Cecília Varjú, László Czirják, Endre Kálmán |
| المصدر: | Lipids in Health and Disease Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Dyslipidaemia, medicine.medical_specialty, RC620-627, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Clinical nutrition, Type 2 diabetes, 030204 cardiovascular system & hematology, Scleroedema, Non-alcoholic fatty liver disease (NAFLD), 030207 dermatology & venereal diseases, 03 medical and health sciences, Diabetes mellitus, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, Fibromucinous thickening, Prevalence, Humans, Mass Screening, Medicine, Nutritional diseases. Deficiency diseases, Scleroderma-like, Stroke, Dyslipidemias, Skin, Scleredema Adultorum, business.industry, Research, Biochemistry (medical), Hypertriglyceridemia, Type 2 Diabetes Mellitus, Odds ratio, Middle Aged, medicine.disease, Lipids, Logistic Models, Diabetes Mellitus, Type 2, Cohort, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business |
| الوصف: | Background Scleroedema adultorum of Buschke is a rare disorder characterized by fibromucinous thickening of the dermis that manifests mainly at the nape of the neck and on the upper back and shoulders. This study screened patients with diabetes mellitus for skin hardening caused by scleroedema adultorum of Buschke and characterized the clinical and laboratory findings in patients with newly identified cases, with a focus on lipid metabolism abnormalities and vascular complications. Methods Out of 113 consecutive patients with diabetes, 11 (9.7%) new scleroedema patients, all with type 2 diabetes, were found. Their clinical and laboratory data were compared to those of the rest of the screened patients and to those of a cohort of 15 patients with scleroedema and diabetes who were already being treated in a tertiary clinical centre at the University of Pécs. Results Higher proportions of patients with dyslipidaemia, hypertriglyceridemia (P P P = 0.021, P P P P = 0.003) were independent predictors of scleroedema in patients with diabetes mellitus. Conclusions Diabetes patients with scleroedema had more severe dyslipidaemia and higher occurrence of vascular complications compared to those without scleroedema. In addition to poorly controlled type 2 diabetes mellitus requiring insulin treatment, high non-HDL-C levels may be another contributing factor to the development of scleroedema. Trial registration NCT04335396. |
| تدمد: | 1476-511X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e42b092ab263012bcb32bf5dc458ceTest https://doi.org/10.1186/s12944-021-01473-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f1e42b092ab263012bcb32bf5dc458ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1476511X |
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