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المؤلفون: Holly Robertson, Albena T. Dinkova-Kostova, John D. Hayes
المصدر: Cancers
Cancers, Vol 12, Iss 3609, p 3609 (2020)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, antioxidant, recurrent disease, Review, adaptation, medicine.disease_cause, chemotherapy, environment and public health, head and neck, 0302 clinical medicine, Cullin 3, oncogene, oxidative stress, chemoprevention, rectum, ATF4, glutathione, bladder, reactive oxygen species, NADPH generation, respiratory system, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncology, 030220 oncology & carcinogenesis, stomach, autophagy, tumour suppressor, pentose phosphate pathway, Biology, liver, lcsh:RC254-282, digestive system, NRF2, lung, 03 medical and health sciences, Downregulation and upregulation, medicine, metastasis, Protein kinase B, PI3K/AKT/mTOR pathway, bioactivation, drug resistance, oesophagus, colon, Cancer, thioredoxin, medicine.disease, KEAP1, NFE2L2, drug metabolism, initiation, 030104 developmental biology, proteasome, quinone-containing drugs, Cancer research, progression, Carcinogenesis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14afe79e3e505f682180a1993dd1f57Test
https://pubmed.ncbi.nlm.nih.gov/33276631Test -
2KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
المؤلفون: Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova
المصدر: Open Biology
Open Biology, Vol 10, Iss 6 (2020)مصطلحات موضوعية: Models, Molecular, Proteasome Endopeptidase Complex, antioxidant, NF-E2-Related Factor 2, Immunology, Inflammation, Review, Review Article, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, NRF2, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, medicine, Humans, Molecular Targeted Therapy, lcsh:QH301-705.5, cysteine, Transcription factor, anti-inflammatory, 030304 developmental biology, Clinical Trials as Topic, 0303 health sciences, Kelch-Like ECH-Associated Protein 1, biology, General Neuroscience, Ubiquitination, respiratory system, KEAP1, Cytoprotection, Cell biology, Ubiquitin ligase, lcsh:Biology (General), redox, 030220 oncology & carcinogenesis, Chronic Disease, biology.protein, medicine.symptom, Cullin, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017809c3d739b04628aa127f1f19a38Test
https://doi.org/10.1098/rsob.200105Test -
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المؤلفون: Albena T. Dinkova-Kostova, Aiten M. Soliman, Mai H. Mekkawy, Mostafa M. Ghorab, Heba M. Karam, Maureen Higgins
المصدر: European Journal of Medicinal Chemistry
مصطلحات موضوعية: Male, Antioxidant, Stereochemistry, medicine.medical_treatment, Thio, Sulfonamide, 01 natural sciences, Antioxidants, Article, Nrf2, Docking, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, medicine, NAD(P)H Dehydrogenase (Quinone), Tumor Cells, Cultured, Moiety, Animals, Inducer, Quinazolinone, 030304 developmental biology, Quinazolinones, Diiodoquinazolinone, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, General Medicine, 0104 chemical sciences, Molecular Docking Simulation, Enzyme, chemistry, Radiomodulatory, Docking (molecular), Oxidative stress, NQO1, Acetamide
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d736d50f9c5871172e527050e1895228Test
https://pubmed.ncbi.nlm.nih.gov/32502866Test -
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المصدر: Molecules, Vol 24, Iss 19, p 3593 (2019)
Moleculesمصطلحات موضوعية: 0301 basic medicine, Pharmaceutical Science, sulforaphane, Disease, Review, Bioinformatics, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Anti-Infective Agents, Isothiocyanates, Drug Discovery, Medicine, nrf2, Glucoraphanin, Clinical Trials as Topic, Molecular Structure, 3. Good health, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Sulfoxides, Chemoprotective, Molecular Medicine, allometric scaling, chemoprotection, Brassica, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Biomarkers, Tumor, Animals, Humans, Microbiome, Physical and Theoretical Chemistry, broccoli, clinical trials, business.industry, Plant Extracts, glucoraphanin, Organic Chemistry, myrosinase, toxicity, Antineoplastic Agents, Phytogenic, Bioavailability, Clinical trial, 030104 developmental biology, chemistry, Isothiocyanate, business, Sulforaphane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b2496ac3653b236a87628394c1f7d0Test
https://www.mdpi.com/1420-3049/24/19/3593Test -
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المؤلفون: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012Test
https://doi.org/10.1016/j.jcmgh.2017.11.016Test -
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المؤلفون: Luke A. J. O'Neill, Dave Speijer, Esther Lutgens, Michel van Weeghel, Annette E. Neele, Koen H.M. Prange, Saskia van der Velden, Albena T. Dinkova-Kostova, Menno P.J. de Winther, Rob C. I. Wüst, Jeroen Baardman, Maarten E. Witte, Simone Denis, Jan Van den Bossche, Elena V. Knatko, Dylan G. Ryan, Sanne G.S. Verberk, Riekelt H. Houtkooper
المساهمون: Molecular cell biology and Immunology, Physiology, Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Medical Biochemistry, AII - Inflammatory diseases, Laboratory Genetic Metabolic Diseases, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, AMS - Ageing & Morbidty, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, ARD - Amsterdam Reproduction and Development
المصدر: Cell Reports, 25(8), 2044-2052.e5. Cell Press
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Test, https://doi.org/10.1016/j.celrep.2018.10.092Test
Cell reports, 25(8), 2044-2052. Cell Press
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Testمصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, NF-E2-Related Factor 2, Citric Acid Cycle, immunometabolism, pentose phosphate pathway, Inflammation, Pentose phosphate pathway, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Nrf2, 03 medical and health sciences, 0302 clinical medicine, Immune system, SDG 3 - Good Health and Well-being, cardiovascular disease, medicine, Macrophage, Animals, lcsh:QH301-705.5, hypercholesterolemia, Chemistry, meta-inflammation, Metabolism, metabolic disease, foam cells, Cell biology, macrophages, Mice, Inbred C57BL, 030104 developmental biology, Cell metabolism, lcsh:Biology (General), inflammation, 030220 oncology & carcinogenesis, Cytokine secretion, Female, medicine.symptom, atherosclerosis, Glycolysis, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ef415f4ba7df2f11e9a8a4f10fe79fTest
https://research.vumc.nl/en/publications/18d3e0ec-b7da-4ccb-bcdd-e585bd6780daTest -
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المصدر: Phytomedicine
مصطلحات موضوعية: NF-E2-Related Factor 2, Pharmaceutical Science, Cellular homeostasis, KEAP1, Kelch-like ECH-associated protein 1, NRF2, nuclear factor erythroid 2 p45-related factor 2, HDAC, histone deacetylase, BITC, benzyl isothiocyanate, NRF2, 03 medical and health sciences, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Isothiocyanates, Cell Line, Tumor, Drug Discovery, Animals, Humans, Kinase activity, AMPK, 5′-AMP-activated protein kinase, PI3K-AKT, phosphatidylinositol 3-kinase-AKT/protein kinase B, Phosphorylation, Protein kinase A, Protein kinase B, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, 030304 developmental biology, SFN, sulforaphane, Pharmacology, 0303 health sciences, biology, NRF2, nuclear factor erythroid 2 p45-related factor 2, Chemistry, PI3K-AKT, mTOR, mechanistic target of rapamycin, TOR Serine-Threonine Kinases, HDAC6, Cell biology, Complementary and alternative medicine, 030220 oncology & carcinogenesis, Sulfoxides, biology.protein, mTOR, Molecular Medicine, Original Article, Sulforaphane, CBHA, m-carboxycinnamic acid bis-hydroxamide, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af06445f4431c6648c6a7e5f775d427Test
http://europepmc.org/articles/PMC8106549Test -
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المؤلفون: Albena T. Dinkova-Kostova, Filip Cvetko, Hiran A. Prag, Michael P. Murphy, Stuart T. Caldwell, Maureen Higgins, Takafumi Suzuki, Richard C. Hartley, Masayuki Yamamoto
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, GCLC, glutamate–cysteine ligase catalytic subunit, thiol oxidation, Mitochondrion, Biochemistry, FB, fractionation buffer, NQO1, NAD(P)H:quinone oxidoreductase-1, Mice, chemistry.chemical_compound, DNM1L, Superoxides, energy metabolism, Homeostasis, Hydrogen peroxide, Cells, Cultured, HO-1, heme oxygenase-1, NAC, N-acetyl-L-cysteine, SFN, sulforaphane, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Nrf2, nuclear factor erythroid 2–related factor 2, respiratory system, DRP1, dynamin-related protein 1, Glutathione, Mitochondria, Cell biology, CDNB, 1-chloro-2,4-dinitrobenzene, Keap1, Kelch-like ECH-associated protein 1, TRX, thioredoxin, Thioredoxin, Oxidation-Reduction, Research Article, Signal Transduction, NF-E2-Related Factor 2, reactive oxygen species (ROS), Nrf2, MitoPQ, MitoParaquat, 03 medical and health sciences, MitoCDNB, CD, concentration required to double, ROS, reactive oxygen species, PGAM5, phosphoglycerate mutase family member 5, Animals, TRXR2, TRX reductase 2, Cysteine, Sulfhydryl Compounds, redox signaling, Molecular Biology, Reactive oxygen species, 030102 biochemistry & molecular biology, Cell Biology, ACN, acetonitrile, MitoCDNB, MitoChlorodinitrobenzoic acid, GSS, GSH synthetase, MEF, mouse embryonic fibroblast, KEAP1, 030104 developmental biology, chemistry, BSA, bovine serum albumin, MitoPQ
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0523882756133409621203d90cd5225Test
https://doi.org/10.1074/jbc.ra120.016551Test -
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المؤلفون: Albena T. Dinkova-Kostova, Jean A. Quinn, Joanne Edwards, Laura Casares, Gunjit Maan, Laura Torrente, Angus W. Jackson, Silvio Bicciato, Ying Zhang, Jani Saarela, Laureano de la Vega, Evgeny Kulesskiy, Asma Oumkaltoum Rezig, Andrea Grilli
المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Biosciences
المصدر: Biomolecules, Vol 10, Iss 1365, p 1365 (2020)
Biomoleculesمصطلحات موضوعية: 0301 basic medicine, POTENT AURORA KINASE, Colorectal cancer, Drug Evaluation, Preclinical, lcsh:QR1-502, environment and public health, Biochemistry, lcsh:Microbiology, NEGATIVE REGULATION, PATHWAY, 0302 clinical medicine, Urea, Medicine, Drug screening, NRF2, SMALL-MOLECULE INHIBITOR, Hyperactivation, Kinase, Communication, TUMOR-GROWTH, respiratory system, 3. Good health, Gene Expression Regulation, Neoplastic, PHASE-I, 030220 oncology & carcinogenesis, Colorectal Neoplasms, Signal Transduction, EXPRESSION, Cell Survival, NF-E2-Related Factor 2, In silico, Aurora inhibitor, colorectal cancer, digestive system, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Humans, LUNG-CARCINOMA, drug screening, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, business.industry, medicine.disease, KEAP1, 030104 developmental biology, Drug Resistance, Neoplasm, Cell culture, Cancer cell, Cancer research, 1182 Biochemistry, cell and molecular biology, Benzimidazoles, 3111 Biomedicine, business, RESISTANCE
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db5a8ccdf6881c79812ba3a75b4bdf6Test
https://doi.org/10.3390/biom10101365Test -
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المؤلفون: Ali Gorji, Albena T Dinkova Kostova, Stjepana Kovac, Nico Melzer, Sven G. Meuth, Alexander M. Herrmann
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1935 (2017)مصطلحات موضوعية: 0301 basic medicine, Review, Pharmacology, Mitochondrion, medicine.disease_cause, Endoplasmic Reticulum, Epileptogenesis, lcsh:Chemistry, Epilepsy, 0302 clinical medicine, Adenosine Triphosphate, Calcium dynamics, Homeostasis, lcsh:QH301-705.5, Spectroscopy, chemistry.chemical_classification, reactive oxygen species, Cell Death, Acquired epilepsy, General Medicine, Computer Science Applications, Mitochondria, NF-E2-Related Factor 2, Biology, Catalysis, Nrf2, Inorganic Chemistry, 03 medical and health sciences, Seizures, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Reactive oxygen species, calcium, Research, Organic Chemistry, Cell Membrane, medicine.disease, Oxidative Stress, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, Calcium Channels, Energy Metabolism, Neuroscience, 030217 neurology & neurosurgery, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b99ddf0d7d6afa74ce83f70daa6f9dTest
https://pubmed.ncbi.nlm.nih.gov/28885567Test