المؤلفون: Crystal D Karakochuk, Mikaela K Barker, Esto Bahizire, Suzanne Vercauteren, Angela M. Devlin, Erick Boy, Timothy J. Green, Pierre Akilimali, Pierrot L. Tugirimana, Amanda M. Henderson, Arianne Albert, Karimah Naguib

المصدر: The Journal of Nutrition. 147:1785-1794

مصطلحات موضوعية: Male, Thalassemia, Medicine (miscellaneous), Hemoglobins, 0302 clinical medicine, hemic and lymphatic diseases, 030212 general & internal medicine, education.field_of_study, Nutrition and Dietetics, Anemia, Iron-Deficiency, biology, Iron Deficiencies, Hemoglobinopathy, Child, Preschool, Democratic Republic of the Congo, Female, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Genotype, Anemia, Iron, 030231 tropical medicine, Population, Nutritional Status, Transferrin receptor, Anemia, Sickle Cell, Glucosephosphate Dehydrogenase, 03 medical and health sciences, Sex Factors, alpha-Thalassemia, Internal medicine, Receptors, Transferrin, parasitic diseases, medicine, Humans, education, Soluble transferrin receptor, business.industry, Genetic Variation, Infant, medicine.disease, Ferritin, Glucosephosphate Dehydrogenase Deficiency, Endocrinology, Ferritins, Immunology, biology.protein, Hemoglobin, business, Biomarkers

الوصف: Background: Anemia is common in Congolese children, and inherited blood disorders may be a contributing cause. The presence of sickle cell variants, X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency and α-thalassemia, has been previously reported. G6PD A- deficiency is characterized by the co-inheritance of G6PD 376 and 202 variants and is common in sub-Saharan Africa.Objective: We aimed to measure the associations between inherited blood disorders and hemoglobin, ferritin, and soluble transferrin receptor (sTfR) concentrations in Congolese children.Methods: Venous blood was collected from 744 children aged 6-59 mo from 2 provinces. We measured biomarkers of nutritional and inflammation status and malaria. Pyrosequencing was used to detect sickle cell variants. Polymerase chain reaction was used to detect G6PD variants and α-thalassemia deletions.Results: Overall, 11% of children had a sickle cell variant, 19% of boys were G6PD A- hemizygotes, 12% and 10% of girls were G6PD A- hetero- or homozygotes, respectively, and 12% of children had α-thalassemia. Multivariable linear regression models (adjusted for age, province, altitude, malaria, and biomarkers of nutritional and inflammation status) showed that G6PD A- hemizygous boys and G6PD 376 homozygous girls had higher sTfR concentrations [geometric mean ratios (95% CIs): 1.20 (1.03, 1.39) and 1.25 (1.02, 1.53), respectively] than children with no G6PD variants. Hemoglobin and ferritin concentrations were not independently associated with any of the inherited blood disorder genotypes.Conclusions: We found that 2 G6PD variant genotypes were associated with elevated sTfR concentrations, which limits the accuracy of sTfR as a biomarker of iron status in this population.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd62d33e26b2971b7111cb1ab3bdd8cTest
https://doi.org/10.3945/jn.117.252635Test

المؤلفون: Ingunn Marie S. Engebretsen, Mala Ali Mapatano, Tor A. Strand, Elin Gjengedal, Branly Kilola Mbunga, Pierre Akilimali

المصدر: Nutrients
Nutrients, Vol 13, Iss 1010, p 1010 (2021)
Volume 13
Issue 3

مصطلحات موضوعية: Rural Population, Pediatrics, medicine.medical_specialty, Anemia, Cross-sectional study, Iron, 030231 tropical medicine, malaria, lcsh:TX341-641, Article, Hemoglobins, 03 medical and health sciences, iron deficiency, 0302 clinical medicine, children, Prevalence, medicine, Humans, 030212 general & internal medicine, Popokabaka, Nutrition and Dietetics, Anemia, Iron-Deficiency, medicine.diagnostic_test, biology, Transferrin saturation, business.industry, Infant, Iron deficiency, medicine.disease, anemia, Ferritin, C-Reactive Protein, Cross-Sectional Studies, Socioeconomic Factors, Child, Preschool, Democratic Republic of the Congo, Serum iron, biology.protein, Hemoglobin, business, lcsh:Nutrition. Foods and food supply, Malaria, Food Science

الوصف: Iron deficiency (ID), the leading cause of anemia and the most common nutritional deficiency globally, is not well reported among children in malaria-endemic settings, and little is known about its contribution to anemia in these settings. We aimed to assess the prevalence of anemia, the role of ID using multiple parameters, and the factors associated with anemia in a malaria-endemic rural area. We conducted a community-based cross-sectional study of 432 children aged 1–5 years from the Popokabaka Health Zone, Democratic Republic of Congo. Sociodemographic characteristics, medical history, anthropometric parameters, and biochemical parameters were considered. Hemoglobin and malaria prevalence were assessed using rapid finger-prick capillary blood testing in the field. Venous blood samples were analyzed for serum ferritin, serum iron, total iron-binding capacity, and C-reactive protein (CRP) in a laboratory. Anemia was found in 294 out of 432 (68%) patients. Malaria was found in 375 out of 432 (87%), and ID in 1.8% according to diagnosis by adjusted ferritin only and in 12.9% according to transferrin saturation. ID indicators were not significantly correlated with low hemoglobin levels. Malaria, fever, and CRP >
5 mg/L were major factors associated with anemia in Popokabaka. Anemia control should focus on treating inflammatory conditions and infectious diseases among children in such settings.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821dc69bf9e843f586f87d03fb71a52dTest
https://doi.org/10.3390/nu13031010Test

المؤلفون: Rosalind S. Gibson, Kristina D. Michaux, Meaghan Hawes, Kyly C. Whitfield, Larry D. Lynd, Pierrot L. Tugirimana, Jennifer Foley, Timothy J. Green, Judy McLean, Crystal D Karakochuk, Lisa A Houghton, Sarah Harvey-Leeson, Pierre Akilimali, Mourad Moursi, Esto Bahizire, Erick Boy

المصدر: Nutrients; Volume 8; Issue 2; Pages: 98
Nutrients
Nutrients, Vol 8, Iss 2, p 98 (2016)

مصطلحات موضوعية: 0301 basic medicine, Gastroenterology, Hemoglobins, chemistry.chemical_compound, iron deficiency, 0302 clinical medicine, Medicine, Micronutrients, 030212 general & internal medicine, Nutrition and Dietetics, Anemia, Iron-Deficiency, biology, Anemia, Iron Deficiencies, Vitamins, deficiency, Micronutrient, Zinc, C-Reactive Protein, Child, Preschool, Democratic Republic of the Congo, lcsh:Nutrition. Foods and food supply, Adult, Vitamin, medicine.medical_specialty, anemia, ferritin, hemoglobin, inflammation, micronutrient, Adolescent, Iron, Nutritional Status, lcsh:TX341-641, Article, Young Adult, 03 medical and health sciences, Internal medicine, Receptors, Transferrin, Humans, Vitamin B12, Soluble transferrin receptor, Inflammation, 030109 nutrition & dietetics, business.industry, Infant, Avitaminosis, medicine.disease, Ferritin, chemistry, Iron-deficiency anemia, Ferritins, Immunology, biology.protein, Zinc deficiency, Deficiency Diseases, business, Food Science

الوصف: Little is known about the micronutrient status of women and children in the Democratic Republic of the Congo, which is critical for the design of effective nutrition interventions. We recruited 744 mother-child pairs from South Kivu (SK) and Kongo Central (KC). We determined hemoglobin (Hb), serum zinc, vitamin B12, folate, ferritin, soluble transferrin receptor (sTfR), retinol binding protein (RBP), C-reactive protein, and α-1 acid glycoprotein concentrations. Anemia prevalence was determined using Hb adjusted for altitude alone and Hb adjusted for both altitude and ethnicity. Anemia prevalence was lower after Hb adjustment for altitude and ethnicity, compared to only altitude, among women (6% vs. 17% in SK; 10% vs. 32% in KC), children 6–23 months (26% vs. 59% in SK; 25% vs. 42% in KC), and children 24–59 months (14% vs. 35% in SK; 23% vs. 44% in KC), respectively. Iron deficiency was seemingly higher with sTfR as compared to inflammation-adjusted ferritin among women (18% vs. 4% in SK; 21% vs. 5% in KC), children 6–23 months (51% vs. 14% in SK; 74% vs. 10% in KC), and children 24–59 months (23% vs. 4% in SK; 58% vs. 1% in KC). Regardless of indicator, iron deficiency anemia (IDA) never exceeded 3% in women. In children, IDA reached almost 20% when sTfR was used but was only 10% with ferritin. Folate, B12, and vitamin A (RBP) deficiencies were all very low (

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2c55d30b565380c8f44fd1c324a6f9Test

المؤلفون: Lisa A Houghton, Erick Boy, Esto Bahizire, Pierrot L. Tugirimana, Timothy J. Green, Pierre Akilimali, Susan I. Barr, Crystal D Karakochuk

المصدر: European journal of clinical nutrition.

مصطلحات موضوعية: 0301 basic medicine, Vitamin, medicine.medical_specialty, 030109 nutrition & dietetics, Nutrition and Dietetics, Calorie, Serum zinc, Medicine (miscellaneous), chemistry.chemical_element, Inflammation, Zinc, Biology, medicine.disease, Obesity, 03 medical and health sciences, chemistry.chemical_compound, Nutrient, Endocrinology, chemistry, Internal medicine, medicine, medicine.symptom, Body mass index

الوصف: Zinc is a negative acute-phase reactant; hence, its concentration decreases in the presence of inflammation. There is no current consensus on how to control for the effect of inflammation on serum zinc, which has implications for accurate estimates of population-level zinc status. We aimed to measure the association between inflammation and serum zinc concentrations and to compare the means and the prevalence of zinc deficiency using unadjusted and inflammation-adjusted serum zinc concentrations among Congolese children.Non-fasting blood was collected in the afternoon in trace element-free vacutainers from 744 apparently healthy children aged 6-59 months in the Democratic Republic of the Congo. Serum was analyzed for zinc, C-reactive protein (CRP) and α-1 acid glycoprotein (AGP) for 665 children with complete data for all three biomarkers. Linear regression was used to generate correction factors (CFs) based on three stages of inflammation: incubation (CRP5 mg/l and normal AGP), early convalescence (CRP5 mg/l and AGP1 g/l) and late convalescence (AGP1 g/l and normal CRP), relative to no inflammation.Overall unadjusted mean±s.d. serum zinc concentration was 9.4±2.1 μmol/l. Study-generated CFs (95% confidence interval) for incubation, early and late convalescence were 1.01 (0.88, 1.14), 1.15 (1.11, 1.21) and 1.07 (1.03, 1.11), respectively. After applying the CFs, overall adjusted mean±s.d. serum zinc concentration was 10.1±2.2 μmol/l, and prevalence of zinc deficiency (8.7 μmol/l) decreased from 35% (n=234/665) to 24% (n=160/665).Adjustment of zinc concentrations for inflammation is warranted when assessing population-level zinc status.European Journal of Clinical Nutrition advance online publication, 23 August 2017; doi:10.1038/ejcn.2017.127.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c985d49e744cdd2ebf45233d84a7e70Test
https://pubmed.ncbi.nlm.nih.gov/28832571Test