نتائج البحث - "Glucagon-Like Peptide-1 Receptor"

1

Effect of Empagliflozin and Liraglutide on the Nucleotide-Binding and Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome in a Rodent Model of Type 2 Diabetes Mellitus

المؤلفون: Patrick Meagher, Mark Gordon, Kim A. Connelly

المصدر: Canadian Journal of Diabetes. 45:553-556

مصطلحات موضوعية: Male, Inflammasomes, medicine.drug_class, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Pharmacology, Pyrin domain, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Glucosides, NLR Family, Pyrin Domain-Containing 3 Protein, Internal Medicine, medicine, Empagliflozin, Animals, 030212 general & internal medicine, Benzhydryl Compounds, Receptor, Sodium-Glucose Transporter 2 Inhibitors, Liraglutide, business.industry, Type 2 Diabetes Mellitus, Inflammasome, General Medicine, medicine.disease, Receptor antagonist, Rats, Disease Models, Animal, Diabetes Mellitus, Type 2, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236da61807a9efbc3204c8e49a0dd8c1Test
https://doi.org/10.1016/j.jcjd.2020.11.003Test

2

Potential Role of Hypothalamic and Plasma Ghrelin in the Feeding Behavior of Obese Type 2 Diabetic Rats with Intraventricular Glucagon-Like Peptide-1 Receptor Agonist Intervention

المؤلفون: Juan Long, Xiaoyan Chen, Ke Lu, Jianhua Yan, Xuelian Deng

المصدر: Obesity Facts, Pp 1-11 (2020)
Obes Facts

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, obesity, medicine.medical_specialty, Health (social science), medicine.drug_class, Period (gene), glucagon-like peptide-1 receptor agonist, Hypothalamus, lcsh:TX341-641, 030209 endocrinology & metabolism, Type 2 diabetes, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Rats, Sprague-Dawley, Eating, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, Animals, Medicine, Receptor, lcsh:RC620-627, Glucagon-like peptide 1 receptor, 030109 nutrition & dietetics, business.industry, digestive, oral, and skin physiology, Feeding Behavior, medicine.disease, Obesity, Ghrelin, Rats, Peripheral, lcsh:Nutritional diseases. Deficiency diseases, Endocrinology, Diabetes Mellitus, Type 2, Exenatide, appetite regulation, type 2 diabetes, business, lcsh:Nutrition. Foods and food supply, hormones, hormone substitutes, and hormone antagonists, Research Article, hypothalamic ghrelin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fd4e0462c558e90b5ad29f1382013eTest
https://doi.org/10.1159/000509956Test

3

A quinoxaline-based compound ameliorates bone loss in ovariectomized mice

المؤلفون: Fen Li, Xiaoyan Xue, Zheng Hou, Zhou Chen, Ying Zhou, Yanyan Guo, Huan Liu, Ning Wang, Yang Wang

المصدر: Exp Biol Med (Maywood)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e852ac7d0f92c81482e781653e9ffeTest
https://doi.org/10.1177/15353702211032133Test

4

Normalisation of glucose metabolism by exendin‐4 in the chronic phase after stroke promotes functional recovery in male diabetic mice

المؤلفون: Vladimer Darsalia, Dimitra Karampatsi, Martin Larsson, Doortje Dekens, Gesine Paul, Thomas Nyström, Osama Elabi, Alexander Zabala, Ingrid Lovise Augestad, Cesare Patrone, Hiranya Pintana

المصدر: British Journal of Pharmacology. 179:677-694

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Agonist, endocrine system, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Type 2 diabetes, Brain damage, Vascular Remodeling, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Vascular remodelling in the embryo, Cicatrix, Mice, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Internal medicine, medicine, Animals, Stroke, Neuroinflammation, Pharmacology, business.industry, Infarction, Middle Cerebral Artery, medicine.disease, Parvalbumins, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Exenatide, Insulin Resistance, medicine.symptom, business, Stroke recovery, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83c8d733941302459781a26c7932715Test
https://doi.org/10.1111/bph.15524Test

5

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

المؤلفون: Lei Zhao, Xinyi Chen, Ho Ko, Joaquim S. L. Vong, Yun Kwok Wing, Junzhe Huang, Vincent Mok, Zhongqi Li, Bonaventure Ip, Leo Y. C. Yan, Hei-Ming Lai

المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Communications Biology

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Cell type, Aging, endocrine system, medicine.drug_class, QH301-705.5, Parkinson's disease, Cell, Medicine (miscellaneous), Biology, General Biochemistry, Genetics and Molecular Biology, Mural cell, Glucagon-Like Peptide-1 Receptor, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Alzheimer Disease, medicine, Animals, Humans, Biology (General), Receptor, Cellular Senescence, Microglia, Cognitive ageing, Neurodegeneration, Brain, Neurodegenerative Diseases, Alzheimer's disease, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Exenatide, Feasibility Studies, General Agricultural and Biological Sciences, Transcriptome, Astrocyte, Neuroscience, Neuroglia, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca8396ea1965a9b468ab96057e62976Test
https://doaj.org/article/b6e03838a0f54cd39260f2154383d3c8Test

6

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

المؤلفون: Xianqiang Sun, Qingtong Zhou, Antao Dai, Honglei Ma, Yan Zhang, Qing Liu, Wenge Zhong, Tian Xia, Xi Wang, Wei Huang, Zhaotong Cong, Li-Nan Chen, Xinyu Zou, Peiyu Xu, Ming-Wei Wang, Dehua Yang, H. Eric Xu, Lihua Zhao, Chenyu Ye

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Agonist, endocrine system, Protein Conformation, G protein, medicine.drug_class, Science, Allosteric regulation, Glucagon-Like Peptides, General Physics and Astronomy, CHO Cells, macromolecular substances, Molecular Dynamics Simulation, Spodoptera, General Biochemistry, Genetics and Molecular Biology, Glucagon-Like Peptide-1 Receptor, Article, Cell Line, 03 medical and health sciences, Computational biophysics, 0302 clinical medicine, Protein structure, Cricetulus, G protein-coupled receptors, Receptor pharmacology, Glucagon-Like Peptide 1, Heterotrimeric G protein, Sf9 Cells, medicine, Animals, Humans, Binding site, Receptor, Enhancer, Multidisciplinary, Binding Sites, Chemistry, Cryoelectron Microscopy, digestive, oral, and skin physiology, General Chemistry, Small molecule, Enzyme Activation, 030104 developmental biology, HEK293 Cells, Diabetes Mellitus, Type 2, Biophysics, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0481bdd863aed3f64acc5050b5a6f169Test
https://doaj.org/article/092caffa900241a1b25c21698353ff0dTest

7

Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 in comparison with liraglutide

المؤلفون: Chiara Dalla Man, Michela Riz, Roberto Visentin, Claudio Cobelli, Thomas Klabunde, Michele Schiavon, Britta Göbel

المصدر: Diabetes, Obesity & Metabolism

مصطلحات موضوعية: Blood Glucose, Agonist, medicine.medical_specialty, medicine.drug_class, beta‐cell function, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Glucagon, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Receptors, Glucagon, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, insulin sensitivity, disposition index, liraglutide, glucagon‐like peptide‐1, beta-cell function, business.industry, Liraglutide, mixed meal tolerance test, Original Articles, medicine.disease, Glucagon-like peptide-1, dual agonist, Glucose, Postprandial, Diabetes Mellitus, Type 2, glucagon, glucagon-like peptide-1, Basal (medicine), oral minimal model, Original Article, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc18c21838d0011d5718b600bf3fdcd2Test
https://doi.org/10.1111/dom.14394Test

8

Effects of Renal Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide

المؤلفون: John Landry, Shweta Urva, Jennifer A. Martin, Tonya Quinlan, Corina Loghin

المصدر: Clinical Pharmacokinetics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f376f4d33db2465f81512718ac090f49Test
https://doi.org/10.1007/s40262-021-01012-2Test

9

Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor

المؤلفون: Daniel A. Briere, David B. Wainscott, José Miguel Minguez, Cynthia Stutsman, Qi Chen, Ana B. Bueno, Alma Jiménez, Kyle W. Sloop, Ana I. Mateo, Guemalli R. Cardona, Wenzhen Ma, Aaron D. Showalter, Graham R Cumming, Ana M. Castaño, Francis S. Willard, Richard W. Zink, Javier Agejas, Nathan Yumibe, Christopher M Corkins

المصدر: Journal of Medicinal Chemistry. 64:3439-3448

مصطلحات موضوعية: Blood Glucose, Models, Molecular, Agonist, endocrine system, Allosteric modulator, medicine.drug_class, Metabolite, Administration, Oral, Pharmacology, 01 natural sciences, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Receptor, 030304 developmental biology, 0303 health sciences, Chemistry, digestive, oral, and skin physiology, Long-term potentiation, Ligand (biochemistry), Glucagon-like peptide-1, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f48ac2debed19ca46755aefd201e2e9Test
https://doi.org/10.1021/acs.jmedchem.1c00029Test

10

Titratable fixed‐ratio combination of basal insulin plus a glucagon‐like peptide‐1 receptor agonist: A novel, simplified alternative to premix insulin for type 2 diabetes

المؤلفون: Julio Rosenstock, Ebaa Al‐Ozairi, Xiaoying Li, Edward B. Jude, Fernando Gomez-Peralta

المصدر: Diabetes, Obesity & Metabolism

مصطلحات موضوعية: Agonist, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulins, 030209 endocrinology & metabolism, Type 2 diabetes, Review Article, 030204 cardiovascular system & hematology, Lower risk, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, GLP‐1 analogue, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, basal insulin, Review Articles, Glucagon-like peptide 1 receptor, Glycated Hemoglobin, business.industry, Basal insulin, medicine.disease, glycaemic control, Diabetes Mellitus, Type 2, insulin therapy, type 2 diabetes, medicine.symptom, Fixed ratio, business, Weight gain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27776b7ce8a86c52613046a313d0f32Test
http://europepmc.org/articles/PMC8252507Test

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