نتائج البحث

1

Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 axes augments antitumor immunity in gastric cancer–T cell coculture models

المؤلفون: Zul Fazreen, Kosaku Mimura, Nicholas Syn, Yuko Nakayama, Jin-Fen Xiao, Wei Peng Yong, Richie Soong, Koji Kono, Bernadette Reyna Asuncion, Ley-Fang Kua

المصدر: Gastric Cancer

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, medicine.medical_treatment, T cell, Programmed Cell Death 1 Receptor, Tim-3, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigens, CD, Stomach Neoplasms, Cell Line, Tumor, PD-L1, PD-1, Humans, Medicine, Cytotoxic T cell, Lectins, C-Type, Cytotoxicity, Aged, Singapore, MHC class II, biology, business.industry, Lag-3, Gastroenterology, General Medicine, Immunotherapy, Survival Analysis, Gene Expression Regulation, Neoplastic, CTL, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Original Article, Combinatorial immunotherapy, Female, Gastric cancer, business, Cell Adhesion Molecules

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b04fb8da0f849665868f13e779a7156Test
https://doi.org/10.1007/s10120-020-01151-8Test

2

The Next-Generation Immune Checkpoint LAG-3 and Its Therapeutic Potential in Oncology: Third Time’s a Charm

المؤلفون: Nick Devoogdt, Marleen Keyaerts, Karine Breckpot, Quentin Lecocq

المساهمون: Basic (bio-) Medical Sciences, Faculty of Medicine and Pharmacy, Supporting clinical sciences, Medical Imaging, Nuclear Medicine, Translational Imaging Research Alliance

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 75, p 75 (2021)
International Journal of Molecular Sciences

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, diagnosis, Lymphocyte, medicine.medical_treatment, Review, Catalysis, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigens, CD, LAG-3, Internal medicine, Neoplasms, Biomarkers, Tumor, Cytotoxic T cell, Medicine, Animals, Humans, cancer, Physical and Theoretical Chemistry, Molecular Biology, Immune Checkpoint Inhibitors, immune checkpoint, lcsh:QH301-705.5, Spectroscopy, business.industry, Organic Chemistry, Cancer, General Medicine, Immunotherapy, medicine.disease, Lymphocyte Activation Gene 3 Protein, Immune checkpoint, Computer Science Applications, Blockade, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Cancer cell, oncology, immunotherapy, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530b3fbaed3209c36a7ad2074e7c6285Test
https://www.mdpi.com/1422-0067/22/1/75Test

3

Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses

المؤلفون: Xiaohui Pan, Bo Yang, Hongjie Guo, Shuyuan Cheng, Xi Chen, Ling Ding, Qiaojun He, Wenxin Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 723-733 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: TIM-3, T cell immunoglobulin and mucin domain 3, H3K27me3, tri-methylation of lysine 27 on histone H3, MDSCs, myeloid-derived suppressor cells, medicine.medical_treatment, Review, TAA, tumor-associated antigen, DC, dendritic cell, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, LAG-3, lymphocyte activation gene-3, CTLA-4, cytotoxic T lymphocyte antigen 4, Medicine, BETi, bromodomain and extra-terminal motif inhibitors, General Pharmacology, Toxicology and Pharmaceutics, FOXP3, forkhead box P3, HDACi, histone deacetylase inhibitor, Cancer, 0303 health sciences, ACE1, angiotensin converting enzyme, CLL, chronic lymphocytic leukemia, biology, IDO, indoleamine 2,3-dioxygenase, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Tregs, regulatory T cells, PD-L1/PD-1 blockade, CCL22 (MDC), macrophage-derived chemokine, Immunotherapy, TET2, ten-eleven translocation 2, CTLs, cytotoxic T lymphocytes, FDA, U. S. Food and Drug Administration, PD-L1, programmed cell death ligand 1, T cell, CTA, cancer testis antigen, Immune cycle, TIL, tumor infiltrating lymphocytes, Epigenetic regulation, OS, overall survival, 03 medical and health sciences, Immune system, Antigen, PD-L1, TH-1, T helper type 1, DNMT1, DNA methyltransferase 1, MHC, major histocompatibility complex, CX3CL1, C-X3-C motif chemokine ligand 1, IFN-γ, interferon-gamma, 030304 developmental biology, business.industry, lcsh:RM1-950, biochemical phenomena, metabolism, and nutrition, medicine.disease, CXCL, CXC chemokine ligand, Blockade, lcsh:Therapeutics. Pharmacology, APC, antigen-presenting cell, UHRF1, ubiquitin-like PHD and RING finger domain-containing 1, 5-AzaC, 5-azacitidine, ACP1, human red cell acid phosphatase, biology.protein, Cancer research, bacteria, DNMTi, DNA methyltransferase inhibitors, PD-1, programmed cell death 1, business, PRC2, polycomb repressive complex 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca7b0479f6fea7a89a3e1eb06905c5Test
https://doi.org/10.1016/j.apsb.2019.09.006Test

4

The New Immunotherapy Combinations in the Treatment of Advanced Non-Small Cell Lung Cancer: Reality and Perspectives

المؤلفون: Danilo Rocco, Cesare Gridelli, Luigi Della Gravara

المصدر: Current Clinical Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, Combination therapy, medicine.medical_treatment, MEDLINE, Ipilimumab, immune modulators, NSCLC, combination therapy, 03 medical and health sciences, 0302 clinical medicine, IDO1, Antineoplastic Agents, Immunological, LAG-3, Internal medicine, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), OX40, General Pharmacology, Toxicology and Pharmaceutics, Lung cancer, Chemotherapy, business.industry, TMB, Clinical Pharmacology, General Medicine, Immunotherapy, medicine.disease, 030104 developmental biology, Tolerability, 030220 oncology & carcinogenesis, Nivolumab, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d40e897b3c0d6259d103a8bd5e3cabTest
http://europepmc.org/articles/PMC7497556Test

5

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

المؤلفون: Ming Yi, Suxia Luo, Shengnan Yu, Linping Xu, Shuang Qin, Kongming Wu

المصدر: Molecular Cancer, Vol 18, Iss 1, Pp 1-14 (2019)
Molecular Cancer

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.drug_class, TIGIT, T-Lymphocytes, T cell, medicine.medical_treatment, TIM-3, Programmed Cell Death 1 Receptor, VISTA, Review, Lymphocyte Activation, Monoclonal antibody, lcsh:RC254-282, Immunomodulation, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Immune system, LAG-3, Neoplasms, Biomarkers, Tumor, medicine, Animals, Humans, CTLA-4 Antigen, Molecular Targeted Therapy, BTLA, Clinical Trials as Topic, biology, Immunotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immune checkpoint, Treatment Outcome, 030104 developmental biology, medicine.anatomical_structure, B7-H3, Oncology, CTLA-4, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Molecular Medicine, Antibody

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ab764b0272cb7de85bf00ba3474375Test
http://link.springer.com/article/10.1186/s12943-019-1091-2Test

6

The immune checkpoint molecules PD-1, PD-L1, TIM-3 and LAG-3 in diffuse large B-cell lymphoma

المؤلفون: Hong Chang, Pallavi Galera, Andrew M. Evens, Vladislav V. Makarenko, Ravi Dashnamoorthy, Srimoyee Ghosh, Benjamin J. Chen

المصدر: Oncotarget
Scopus-Elsevier

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691259913c941e373e7014eb11a37fd9Test
http://europepmc.org/articles/PMC6459346Test

7

Understanding LAG-3 Signaling

المؤلفون: Ruth Vera, Pablo Ramos, David Escors, Gonzalo Fernandez-Hinojal, Miriam Echaide, Grazyna Kochan, Hugo Arasanz, Maider Garnica, Ana Bocanegra, Luisa Chocarro, Miren Zuazo, Leticia Fernández-Rubio, E. Blanco, Pilar Morente

المساهمون: Universidad Pública de Navarra. Departamento de Ciencias de la Salud, Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila, Gobierno de Navarra / Nafarroako Gobernua

المصدر: Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5282, p 5282 (2021)

مصطلحات موضوعية: QH301-705.5, T-Lymphocytes, medicine.medical_treatment, T cell, Cell, Review, Biology, Lymphocyte Activation, Inhibitory postsynaptic potential, Catalysis, Inorganic Chemistry, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cancer immunotherapy, Antigens, CD, LAG-3, Neoplasms, medicine, Humans, Biology (General), Receptors, Immunologic, Physical and Theoretical Chemistry, Receptor, QD1-999, Molecular Biology, Spectroscopy, 030304 developmental biology, 0303 health sciences, Organic Chemistry, General Medicine, Immunotherapy, Lymphocyte Activation Gene 3 Protein, Immune checkpoint, 3. Good health, Computer Science Applications, Cell biology, Chemistry, medicine.anatomical_structure, Cancer signaling, Signal Transduction, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a65a608d5e3690ea9591c575ec3026cTest
https://hdl.handle.net/2454/41811Test

8

Cell by cell immuno- and cancer marker profiling of non-small cell lung cancer tissue: Checkpoint marker expression on CD103+, CD4+ T-cells predicts circulating tumor cells

المؤلفون: Priya Gogoi, Maria Jaimes, Vishal P. Sharma, Keith Shults, Will Chow, Bruce K. Patterson, Santosh Putta, Huimin Gu, Kalyan Handique, Xiaoyang Wang

المصدر: Translational Oncology
Translational Oncology, Vol 14, Iss 1, Pp 100953-(2021)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Original article, CCR5, CC chemokine receptor 5, medicine.medical_treatment, TIM-3, mucin domain-3-containing molecule-3, TIL, tumor infiltrating lymphocyte, lcsh:RC254-282, High parameter flow cytometry, Targeted therapy, Cancer marker, 03 medical and health sciences, 0302 clinical medicine, Circulating tumor cell, Non-small cell lung cancer, medicine, Tumor infiltrating lymphocyte, neoplasms, LAG-3, lymphocyte-activation gene-3, biology, Tumor-infiltrating lymphocytes, ALK, anaplastic lymphoma kinase, CD44, TME, tumor microenvironment, Immunotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Aneuploidy, Immune checkpoint, respiratory tract diseases, EGFR, epidermal growth factor receptor, PD-L1, programmed death-ligand 1, 030104 developmental biology, Oncology, Tumor microenvironment, CTLA-4, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Cancer research, PD-1, programmed death-1, CTLA-4, cytotoxic T-lymphocyte antigen-4, CCR5, LAG3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecab16bcda00a3c50791646d2116fe51Test
http://europepmc.org/articles/PMC7683336Test

9

Building a Bridge between Chemotherapy and Immunotherapy in Malignant Pleural Mesothelioma: Investigating the Effect of Chemotherapy on Immune Checkpoint Expression

المؤلفون: Jonas Van Audenaerde, Jinthe Van Loenhout, Julie Jacobs, Patrick Pauwels, Elly Marcq, Jorrit De Waele, Jan P. van Meerbeeck, Glenn Cavents, Evelien Smits

المصدر: International Journal of Molecular Sciences
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4182 (2019)
International journal of molecular sciences

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, medicine.medical_treatment, MPM, Gene Expression, chemotherapy, lcsh:Chemistry, 0302 clinical medicine, Antineoplastic Agents, Immunological, Antineoplastic Combined Chemotherapy Protocols, PD-1, Mesothelioma, Molecular Targeted Therapy, lcsh:QH301-705.5, Spectroscopy, biology, General Medicine, Combined Modality Therapy, Computer Science Applications, Chemistry, Pemetrexed, 030220 oncology & carcinogenesis, mesothelioma, Immunotherapy, medicine.drug, PD-L1, TIM-3, Antineoplastic Agents, Catalysis, Article, Inorganic Chemistry, Immunomodulation, 03 medical and health sciences, LAG-3, Cell Line, Tumor, medicine, Biomarkers, Tumor, Animals, Humans, tumor microenvironment, Physical and Theoretical Chemistry, Biology, Molecular Biology, Cisplatin, Chemotherapy, business.industry, Organic Chemistry, Mesothelioma, Malignant, immune checkpoints, medicine.disease, Immune checkpoint, Oxaliplatin, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, biology.protein, Cancer research, Human medicine, business

وصف الملف: application/pdf; pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1867699192e142b0bd4c1411738ddbcTest

10

Combination immunotherapy strategies in advanced non-small cell lung cancer (NSCLC): Does biological rationale meet clinical needs?

المؤلفون: Alberto Pavan, Filippo de Marinis, Laura Bonanno, Antonio Passaro, Ilaria Attili, Pierfranco Conte

المصدر: Critical Reviews in Oncology/Hematology. 119:30-39

مصطلحات موضوعية: PD-L1, 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Programmed Cell Death 1 Receptor, non-small cell lung cancer (NSCLC), Disease, B7-H1 Antigen, IDO, 03 medical and health sciences, 0302 clinical medicine, LAG-3, Carcinoma, Non-Small-Cell Lung, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, Medicine, CTLA-4 Antigen, Lung cancer, Antiangiogenic treatment, CTLA-4, Combination treatment, Immune checkpoint, Tumor microenvironment, biology, business.industry, Antibodies, Monoclonal, Hematology, medicine.disease, Radiation therapy, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, biology.protein, Tumor Escape, Immunotherapy, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc111800f5ade8f2fadbfbd81d2cc88Test
https://doi.org/10.1016/j.critrevonc.2017.09.007Test

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