TSH-receptor antibodies may prevent bone loss in pre- and postmenopausal women with Graves' disease and Graves' orbitopathy
| العنوان: | TSH-receptor antibodies may prevent bone loss in pre- and postmenopausal women with Graves' disease and Graves' orbitopathy |
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| المؤلفون: | Aleksandra Tsukeva, Kiril Hristozov, Mira Siderova |
| المصدر: | Archives of Endocrinology and Metabolism v.62 n.2 2018 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM Archives of Endocrinology and Metabolism, Vol 62, Iss 2, Pp 221-226 Archives of Endocrinology and Metabolism, Volume: 62, Issue: 2, Pages: 221-226, Published: MAR 2018 |
| بيانات النشر: | Archives of Endocrinology and Metabolism, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, FRAX, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Graves' disease, Osteoporosis, lcsh:Medicine, Thyrotropin, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Gastroenterology, Bone remodeling, Graves' orbitopathy, Fractures, Bone, Absorptiometry, Photon, 0302 clinical medicine, Bone Density, Reference Values, Risk Factors, Osteoporosis, Postmenopausal, Bone mineral, Middle Aged, musculoskeletal system, Graves Disease, Thyrotoxicosis, medicine.anatomical_structure, Female, hormones, hormone substitutes, and hormone antagonists, Immunoglobulins, Thyroid-Stimulating, Adult, musculoskeletal diseases, Thyroid Hormones, endocrine system, medicine.medical_specialty, 030209 endocrinology & metabolism, Trab, Risk Assessment, 03 medical and health sciences, Internal medicine, medicine, TSH-receptor antibodies, Humans, Risk factor, Glucocorticoids, Aged, Femoral neck, lcsh:RC648-665, business.industry, lcsh:R, medicine.disease, osteoporosis, Graves Ophthalmopathy, 030104 developmental biology, Case-Control Studies, bone mineral density, business |
| الوصف: | Objective Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves' orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves' thyrotoxicosis and Graves' orbitopathy (GO). Subjects and methods Forty seven women with Graves' disease, mean age 55.6 ± 12.8 (23 women with thyrotoxicosis and 24 hyperthyroid with concomitant GO and glucocorticoid therapy) and 40 age-matched healthy female controls were enrolled in the study. We analyzed clinical features, TSH, FT4, FT3, TRAb, TPO antibodies. BMD of lumbar spine and hip was measured by DEXA and 10-year fracture risk was calculated with FRAX tool. Results The study showed significantly lower spine and femoral BMD (g/cm2) in patients with and without GO compared to controls, as well as significantly higher fracture risk. Comparison between hyperthyroid patients without and with orbitopathy found out significantly lower spine BMD in the first group (p = 0.0049). Negative correlations between FT3 and femoral neck BMD (p = 0.0001), between FT4 and BMD (p = 0.049) and positive between TSH and BMD (p = 0.0001), TRAb and BMD (p = 0.026) were observed. Fracture risk for major fractures and TRAb were negatively associated (p = 0.05). We found negative correlation of BMD to duration of thyrotoxicosis and cumulative steroid dose. Conclusions Our results confirm the negative effect of hyperthyroid status on BMD. TRAb, often in high titers in patients with GO, may have protective role for the bone, but further research is needed. |
| وصف الملف: | text/html |
| تدمد: | 2359-4292 2359-3997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5064efeaf530136a1afae5b4461fc35Test https://doi.org/10.20945/2359-3997000000027Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f5064efeaf530136a1afae5b4461fc35 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23594292 23593997 |
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