نتائج البحث - "Glucagon-Like Peptide-1 Receptor"

المساهمون: Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), The Academy of Medical Sciences, Society for Endocrinology, European Foundation for the Study of Diabetes, British Society for Neuroendocrinology, Wellcome Trust

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Ligands, Biochemistry, Mice, Glucagon-Like Peptide 1, Insulin Secretion, DPP-4, dipeptidyl dipeptidase-4, Functional selectivity, Cyclic AMP, Receptor, beta-Arrestins, 11 Medical and Health Sciences, GIP, diabetes, Chemistry, membrane trafficking, GIP, glucose-dependent insulinotropic polypeptide, GLP-1, glucagon-like peptide-1, incretin, GCGR, glucagon receptor, biased agonism, receptor endocytosis, 03 Chemical Sciences, Signal Transduction, Research Article, Agonist, medicine.medical_specialty, Biochemistry & Molecular Biology, GIPR, glucose-dependent insulinotropic polypeptide receptor, medicine.drug_class, GPCR, G protein–coupled receptors, Incretin, T2D, type 2 diabetes, Gastric Inhibitory Polypeptide, Incretins, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, Downregulation and upregulation, DERET, diffusion-enhanced resonance energy transfer, trafficking, Internal medicine, medicine, Arrestin, Animals, Humans, Molecular Biology, GCG, glucagon, G protein-coupled receptor, 030102 biochemistry & molecular biology, β-arrestin, molecular pharmacology, Cell Biology, 06 Biological Sciences, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, HEK293 Cells, glucagon, MAPK, mitogen-activated protein kinases, PKA, protein kinase A, GLP-1, Glucagon receptor, GLP-1R, glucagon-like peptide-1 receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14471befc4ee6d914cdba212a163e9f9Test
http://hdl.handle.net/10044/1/85112Test

8

Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent

المؤلفون: Elvira Alvarez, Ana Pérez-García, García-Mauriño Je, Pilar Dongil, Carmen Sanz, Carmen Herrero-de-Dios, María Dolores Ponce Sánchez, Verónica Hurtado-Carneiro

المصدر: Nutrients, Vol 13, Iss 2552, p 2552 (2021)
Nutrients
Volume 13
Issue 8

مصطلحات موضوعية: Male, 0301 basic medicine, Receptors, Cytoplasmic and Nuclear, Energy homeostasis, Mice, chemistry.chemical_compound, metabolic sensors, 0302 clinical medicine, Glucagon-Like Peptide 1, exendin-4, TX341-641, glucose, Glucose Transporter Type 2, glucokinase, Nutrition and Dietetics, Glycogen, biology, diabetes, Chemistry, digestive, oral, and skin physiology, Adaptation, Physiological, Up-Regulation, Liver, feeding, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, endocrine system, fasting, Nutritional Status, Protein Serine-Threonine Kinases, Article, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Internal medicine, Weight Loss, medicine, Animals, Glycogen synthase, Protein kinase B, Glucokinase, Nutrition. Foods and food supply, Glucose transporter, Metabolism, Liver Glycogen, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, biology.protein, Exenatide, GLUT2, Proto-Oncogene Proteins c-akt, 030217 neurology & neurosurgery, Food Science

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f105cd5395aa14b9c8976e90e255d23Test
https://www.mdpi.com/2072-6643/13/8/2552Test

9

GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action

المؤلفون: June Zhi Xu, James Littrell, Seunghun Paul Lee, Guozhang Xu, Matthew Rankin, Jenson Qi, Ivona Bakaj, Alessandro Pocai

المصدر: Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology

مصطلحات موضوعية: 0301 basic medicine, obesity, insulin secretion, CKD - chronic kidney disease, G-Protein-Coupled Receptor Kinase 1, Endocrinology, Diabetes and Metabolism, Endogeny, GRK2 = G protein–coupled receptor kinase 2, Eating, Mice, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, Receptors, Glucagon, Insulin, Phosphorylation, Receptor, beta-Arrestins, Original Research, biology, diabetes, Chemistry, Kinase, digestive, oral, and skin physiology, NASH, Glucagon-like peptide-1, Cell biology, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, endocrine system, Dipeptidyl Peptidase 4, CHO Cells, Carbohydrate metabolism, Glucagon-Like Peptide-1 Receptor, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Islets of Langerhans, Cricetulus, Diabetes Mellitus, Animals, Humans, Renal Insufficiency, Chronic, Dipeptidyl peptidase-4, G protein-coupled receptor, Beta adrenergic receptor kinase, RC648-665, Amides, 030104 developmental biology, Glucose, biology.protein, Calcium, GLP-1, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440f9f5baedcb64f3b7c2909187f7092Test

10

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

المؤلفون: Philip Pickford, Guy A. Rutter, Alejandra Tomas, Stephen R. Bloom, James Minnion, Ben Jones, Katja Schoeneberg, Stavroula Bitsi, Jan Ungewiss, Maria Lucey

المساهمون: Medical Research Council (MRC), The Academy of Medical Sciences, Society for Endocrinology, European Foundation for the Study of Diabetes

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 37, Iss, Pp 100991-(2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Acylation, GLP-1RA, glucagon-like peptide-1 receptor agonist, Pharmacology, 0601 Biochemistry and Cell Biology, law.invention, Mice, 0302 clinical medicine, n.c., not calculable, law, Glucagon-Like Peptide 1, Receptors, Glucagon, Receptor, TR-FRET, time-resolved Förster resonance energy transfer, Trafficking, Chemistry, Type 2 diabetes, Ligand (biochemistry), Glucagon-like peptide-1, 3. Good health, cAMP, cyclic adenosine monophosphate, FITC, fluorescein isothiocyanate, Signal Transduction, lcsh:Internal medicine, PBS, phosphate-buffered saline, 030209 endocrinology & metabolism, T2D, type 2 diabetes, AUC, area under curve, Brief Communication, SEM, standard error of the mean, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Pharmacokinetics, Confocal microscopy, In vivo, Potency, Animals, Humans, HTRF, homogenous time-resolved fluorescence, lcsh:RC31-1245, HBSS, Hank's buffered salt solution, Molecular Biology, Biased signalling, Dose-Response Relationship, Drug, Exendin-4, Cell Biology, DIO, diet-induced obesity, LC/MSMS, liquid chromatography/tandem mass spectrometry, 0606 Physiology, Peptide Fragments, 030104 developmental biology, Glucose, HEK293 Cells, Exenatide, Blood sugar regulation, BSA, bovine serum albumin, Peptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eea458e3c27345ef8e319b61a8f529fTest
https://pubmed.ncbi.nlm.nih.gov/32278079Test

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