Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy
| العنوان: | Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy |
|---|---|
| المؤلفون: | Shohreh Issazadeh-Navikas, Ava Handley, Roger Pocock, Pedro Moreira, Sandeep Gopal, Camilla Nehammer, Huikyong Lee, Leelee Ng, Patrick Ejlerskov, David C. Rubinsztein |
| المساهمون: | Handley, Ava [0000-0003-1543-1551], Rubinsztein, David C [0000-0001-5002-5263], Pocock, Roger [0000-0002-5515-3608], Apollo - University of Cambridge Repository |
| المصدر: | eLife, Vol 8 (2019) eLife Nehammer, C, Ejlerskov, P, Gopal, S, Handley, A, Ng, L, Moreira, P, Lee, H, Issazadeh-Navikas, S, Rubinsztein, D C & Pocock, R 2019, ' Interferon-beta-induced miR-1 alleviates toxic protein accumulation by controlling autophagy ', eLife, vol. 8 . https://doi.org/10.7554/eLife.49930Test |
| بيانات النشر: | eLife Sciences Publications Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_treatment, Protein aggregation, Mice, 0302 clinical medicine, Interferon, genetics, mammalian cells, Biology (General), 3' Untranslated Regions, Caenorhabditis elegans, Huntingtin Protein, biology, microRNA, Chemistry, General Neuroscience, GTPase-Activating Proteins, General Medicine, 3. Good health, Cell biology, Cytokine, C. elegans, Medicine, Research Article, medicine.drug, autophagy, QH301-705.5, Science, Chemical biology, chemical biology, General Biochemistry, Genetics and Molecular Biology, protein aggregation, Protein Aggregates, 03 medical and health sciences, Biochemistry and Chemical Biology, genomics, medicine, biochemistry, Animals, Humans, RNA, Messenger, Caenorhabditis elegans Proteins, Base Sequence, General Immunology and Microbiology, human cells, Autophagy, rab7 GTP-Binding Proteins, Genetics and Genomics, Interferon-beta, biology.organism_classification, MicroRNAs, 030104 developmental biology, rab GTP-Binding Proteins, Mutant Proteins, Rab, Peptides, 030217 neurology & neurosurgery, HeLa Cells |
| الوصف: | Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. Here, we report that the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous Tre-2/Bub2/CDC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorhabditis elegans and mammalian cells, respectively. Loss of miR-1 causes TBC-7/TBC1D15 overexpression, leading to a block on autophagy. Further, we found that the cytokine interferon-β (IFN-β) can induce miR-1 expression in mammalian cells, reducing TBC1D15 levels, and safeguarding against proteotoxic challenges. Therefore, this work provides a potential therapeutic strategy for protein aggregation disorders. |
| وصف الملف: | application/pdf; application/zip; text/xml |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34810bf881501a7c32975e5884fc3cf7Test https://elifesciences.org/articles/49930Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....34810bf881501a7c32975e5884fc3cf7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |