Folate- and glucuronate-functionalization of layered double hydroxides containing dysprosium and gadolinium and the effect on oxidative stress in rat liver mitochondria
| العنوان: | Folate- and glucuronate-functionalization of layered double hydroxides containing dysprosium and gadolinium and the effect on oxidative stress in rat liver mitochondria |
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| المؤلفون: | Fermín Paul Pacheco Moisés, Cecilia Sánchez Juménez, M.E. Cano, Ana Laura Briones Torres, Gregorio Guadalupe Carbajal Arízaga, Karina Nava Andrade |
| المصدر: | Heliyon Heliyon, Vol 6, Iss 1, Pp e03111-(2020) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Ceramics, Glucuronate, Gadolinium, chemistry.chemical_element, Zinc, engineering.material, Magnetization, Article, Nanocomposites, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Social sciences (General), lcsh:Science (General), Magnetic materials, Functionalization, Multidisciplinary, Toxicity, Layered double hydroxides, Basic precipitation, 030104 developmental biology, chemistry, Layered double hydroxide, Dysprosium, engineering, Hydroxide, Surface modification, lcsh:H1-99, Biomedical materials, Pharmaceutical chemistry, 030217 neurology & neurosurgery, Nuclear chemistry, lcsh:Q1-390 |
| الوصف: | Zinc/aluminum layered double hydroxide (LDH) particles were prepared by alkaline precipitation in the presence of dysprosium and dysprosium/gadolinium cations. The particles formed were stable against exchange reactions with folate or glucuronate ions since these organic ions exclusively functionalized the external surface of the layered double hydroxides. While the dysprosium derivatives reached magnetization susceptibilities between 2.06 × 10−5 and 2.20 × 10−5 cm3/g, the samples simultaneously containing dysprosium and gadolinium decreased to a range between 1.08 × 10−5 and 1.73 × 10−5 cm3/g. This last sample was tested as a magnetic resonance imaging contrast agent and demonstrated a reduction in T1 and T2 relaxation times in a linear dependence with the LDH concentration. The oxidative stress assays in rat liver mitochondria demonstrated the low toxicity of the composition simultaneously containing dysprosium and gadolinium as well as the functionalization product with glucuronate ions, suggesting the potential of these particles to design alternative MRI contrast agents. Nanocomposites; Biomaterials; Ceramics; Biomedical materials; Magnetic materials; Pharmaceutical chemistry; Functionalization; Toxicity; Layered double hydroxide; Magnetization |
| تدمد: | 2405-8440 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf9d3f4469d36430fb1b83e4c8c2642Test https://pubmed.ncbi.nlm.nih.gov/31909275Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0cf9d3f4469d36430fb1b83e4c8c2642 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24058440 |
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