المؤلفون: Kyung-Jo Kim, Sung Wook Hwang, Jeong-Sik Byeon, Jae Cheol Park, Seung-Jae Myung, Byong Duk Ye, Dong-Uk Kang, Suk-Kyun Yang, Sang Hyoung Park, Dong-Hoon Yang

المصدر: Colorectal Disease. 22:2008-2017

مصطلحات موضوعية: medicine.medical_specialty, Multivariate analysis, Endoscopic Mucosal Resection, business.industry, Large tumour, Dissection, Medical record, Perforation (oil well), Hazard ratio, Gastroenterology, Endoscopic submucosal dissection, Surgery, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, 030220 oncology & carcinogenesis, Humans, Medicine, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, Stage (cooking), Colorectal Neoplasms, business, Adverse effect, Retrospective Studies

الوصف: AIM The main aim of this study was to compare the long-term outcome of a conventional colorectal endoscopic submucosal dissection (ESD) in which submucosal dissection was continued throughout until the completion of resection (ESD-T) to hybrid endoscopic submucosal dissection (ESD-H) in the colorectum. METHOD Medical records of 836 colorectal neoplasia patients treated by ESD-T or ESD-H were reviewed. ESD-H was defined as colorectal ESD with additional snaring in the final stage of the procedure. Primary outcomes were the overall and metastatic recurrence rates. Secondary outcomes were short-term outcomes such as the en bloc resection rate, procedure time and adverse events. RESULTS The overall recurrence rate was higher in the ESD-H than in the ESD-T group (5.7% vs 0.7%, P = 0.001). The metastatic recurrence rate showed no significant difference between these groups (1.4% vs 1.4%, P = 1.000). Multivariate analysis revealed that a failed en bloc resection (hazard ratio 24.097; 95% CI 5.446-106.237; P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c9186242c4432905750d3c438206b6Test
https://doi.org/10.1111/codi.15339Test

المؤلفون: Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Sun-Ho Lee, Sung Wook Hwang, Kiju Chang, Jihun Kim, Eun Mi Song, Dong-Hoon Yang, Sang Hyoung Park

المصدر: Journal of Gastroenterology and Hepatology. 34:1581-1589

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Databases, Factual, Endoscopic Mucosal Resection, Colon, medicine.medical_treatment, Clinical Decision-Making, Young Adult, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Recurrence, Risk Factors, medicine, Humans, Patient group, Referral and Consultation, Colectomy, Aged, Retrospective Studies, R0 resection, Hepatology, business.industry, Patient Selection, Gastroenterology, Treatment options, Colonoscopy, Endoscopic submucosal dissection, Length of Stay, Middle Aged, medicine.disease, Ulcerative colitis, Surgery, Treatment Outcome, Dysplasia, 030220 oncology & carcinogenesis, Feasibility Studies, Colitis, Ulcerative, Female, 030211 gastroenterology & hepatology, business, Endoscopic treatment

الوصف: Background and aim The feasibility of endoscopic submucosal dissection (ESD) as a treatment option for dysplasia in ulcerative colitis (UC) has been reported, but the associated therapeutic decision-making and clinical outcomes have not been extensively investigated. Methods We retrospectively reviewed 25 UC patients who were referred for potential ESD of non-polypoid or sessile dysplasia. We analyzed the treatment decisions and the ESD and colectomy outcomes for this patient group. Results All lesions were located at the colitic segments. The median UC duration was 13.4 years. A colectomy was recommended for 10 patients because of ulceration with indistinct borders (one patient), non-ulceration with indistinct borders (two patients), and non-lifting signs (seven patients). The remaining 15 patients underwent ESD. The en bloc and R0 resection rates were 93.3% and 80%, respectively. The median hospitalization periods were 1 (range, 1-2) day after ESD and 7 (range, 5-30) days after colectomy. No procedure-related complications occurred after ESD, but early and late postoperative complications occurred in two (22.2%) and six (66.7%) of the colectomized patients, respectively. Fourteen ESD cases were followed endoscopically for a median period of 24.7 (range, 5.2-64.8) months. Local recurrence occurred in 2 (14.3%) patients, and metachronous recurrence was identified in two separate patients (14.3%). Conclusions Endoscopic submucosal dissection is a feasible endoscopic treatment option for UC-associated dysplasia showing noninvasive pit or vascular patterns, no surface ulceration, distinct borders, and appropriate lifting after submucosal injection. Meticulous endoscopic surveillance is essential to monitor for local or metachronous recurrence of dysplasia after ESD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa60f63067569192b43a659561ca8baTest
https://doi.org/10.1111/jgh.14623Test

المؤلفون: Jeong-Sik Byeon, Seung-Jae Myung, Sang Hyoung Park, Byong Duk Ye, M. K. Kwak, Suk-Kyun Yang, Shai Friedland, Dong-Hoon Yang, Hyun Gun Kim

المصدر: Clinical Endoscopy, Vol 50, Iss 4, Pp 379-387 (2017)
Clinical Endoscopy

مصطلحات موضوعية: lcsh:Internal medicine, medicine.medical_specialty, Colon, Medicine (miscellaneous), Rectum, chemical and pharmacologic phenomena, Endoscopic mucosal resection, complex mixtures, Gastroenterology, Resection, Lesion, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, health services administration, Internal medicine, parasitic diseases, medicine, Radiology, Nuclear Medicine and imaging, lcsh:RC799-869, lcsh:RC31-1245, Procedure time, business.industry, En bloc resection, Endoscopic submucosal dissection, Surgery, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Original Article, lcsh:Diseases of the digestive system. Gastroenterology, 030211 gastroenterology & hepatology, medicine.symptom, Complication, business

الوصف: Background/Aims Endoscopic mucosal resection with circumferential mucosal incision (CMI-EMR) may offer benefits comparable to those of endoscopic submucosal dissection (ESD), while requiring less technical proficiency than ESD. Methods We retrospectively compared the outcomes of CMI-EMR (n=34) and size-matched ESD (n=102), which were performed by a Korean endoscopist for colorectal epithelial lesions of 20–35 mm. Procedural parameters of CMI-EMRs performed by an American ESD novice (n=30) were compared with those performed by the Korean endoscopist. Results The lesion size was 22.3±3.9 mm and 22.9±2.4 mm in the CMI-EMR and size-matched ESD groups, respectively (p=0.730). The resection time was 12.7±7.0 minutes in the CMI-EMR group and 45.6±30.1 minutes in the ESD group (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976d6acac974ebe41c5d72778707fe9eTest
https://doi.org/10.5946/ce.2016.058Test

المؤلفون: Jeong-Sik Byeon, Nam Seok Ham, Dong-Hoon Yang, Byong Duk Ye, Jeongseok Kim, Seung-Jae Myung, Sang Hyoung Park, Eun Hye Oh, Sung Wook Hwang, Suk-Kyun Yang

المصدر: Digestive diseases and sciences. 65(4)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adenoma, Endoscopic Mucosal Resection, Physiology, Cost-Benefit Analysis, Endoscopic mucosal resection, Complete resection, Resection, 03 medical and health sciences, Indirect costs, 0302 clinical medicine, Internal medicine, medicine, Humans, Procedure time, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Gastroenterology, Endoscopic submucosal dissection, Hepatology, Middle Aged, medicine.disease, Surgery, Treatment Outcome, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, business, Colorectal Neoplasms, Follow-Up Studies

الوصف: Few studies have compared the costs of colorectal endoscopic submucosal dissection (ESD) and endoscopic piecemeal mucosal resection (EPMR). Here, we aimed to investigate the cost-effectiveness of these approaches by analyzing clinical outcomes and costs. Data from patients undergoing colorectal ESD and EPMR were retrospectively reviewed. Clinical outcomes (procedure time, complete resection, and recurrence) were compared, and total direct costs (procedural and follow-up) were assessed. Data from 429 ESD and 115 EPMR patients were included in the analysis. The complete resection rate was significantly higher (83.9% vs. 32.2%, p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6316bcd64b48ee93c1734ac3f3165c2dTest
https://pubmed.ncbi.nlm.nih.gov/31493041Test

المؤلفون: Dong-Hoon Yang, Seohyun Lee, Seungyun Lee, Jung Ho Bae, Jeong-Sik Byeon, Jae Seung Soh, Kyung-Jo Kim, Hyo Jeong Lee, Ho-Su Lee, Suk-Kyun Yang, Sang Hyoung Park, Seung-Jae Myung, Byong Duk Ye

المصدر: Gastrointestinal Endoscopy. 83:584-592

مصطلحات موضوعية: Adenoma, Adult, Male, medicine.medical_specialty, Endoscopic Mucosal Resection, Operative Time, Perforation (oil well), Colonic Polyps, Colonoscopy, Endoscopic mucosal resection, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Intestinal mucosa, law, Carcinoma, medicine, Humans, Radiology, Nuclear Medicine and imaging, Intestinal Mucosa, Aged, Colorectal Tumors, Aged, 80 and over, medicine.diagnostic_test, business.industry, Gastroenterology, Endoscopic submucosal dissection, Middle Aged, medicine.disease, Surgery, Treatment Outcome, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business

الوصف: Background and Aims Colorectal endoscopic submucosal dissection (ESD) is difficult and time consuming. Optimization of ESD with snaring (optimized hybrid ESD) may shorten the procedure time. The purpose of this study was to prospectively compare ESD and optimized hybrid ESD in the colorectum. Methods We prospectively enrolled 70 patients with colorectal neoplasia ≥20 mm. The patients were randomized to receive either ESD (36 patients) or optimized hybrid ESD (34 patients). In the optimized hybrid ESD group, snare resection was performed after an adequate amount of submucosal dissection. The primary outcome was procedure time. Secondary outcomes were en bloc and complete resection rates and adverse event rates. Results ESD could not be completed in 5 patients (13.9%) in the ESD group because of technical difficulties. We tried hybrid ESD to finish the resection, and en bloc resection was achieved in 4 patients (80%). The mean procedure time was shorter in the optimized hybrid ESD group compared with the ESD group (27.4 vs 40.6 minutes; P = .005). The en bloc resection rates were similar (94.1% vs 100%; P = .493), as were the complete resection rates (91.2% vs 93.5%; P > .999) and perforation rates (3 patients [8.8%] vs 2 patients [6.5%]; P > .999). Conclusions Optimized hybrid ESD achieves shorter procedure times than ESD, with similar en bloc resection rates and adverse event rates. Optimized hybrid ESD in the colorectum may offer an easy alternative to colorectal ESD and a rescue method for failed ESD cases. (Clinical trial registration number: NCT01944540.)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21551cf91c44522a702e77ed4abbe60Test
https://doi.org/10.1016/j.gie.2015.06.057Test

المؤلفون: Sang Hyoung Park, Byong Duk Ye, Kyung-Jo Kim, Jeong-Sik Byeon, Myeongsook Seo, Seung-Jae Myung, Gwang Un Kim, Dong-Hoon Yang, Jihun Kim, Sung Wook Hwang, Eun Mi Song, Suk-Kyun Yang

مصطلحات موضوعية: Male, medicine.medical_specialty, Endoscopic Mucosal Resection, Endoscopic mucosal resection, Complete resection, Resection, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Odds Ratio, Medicine, Humans, Intestinal Mucosa, Aged, Retrospective Studies, business.industry, Gastroenterology, En bloc resection, Retrospective cohort study, Odds ratio, Endoscopic submucosal dissection, Middle Aged, Fibrosis, Confidence interval, Surgery, Treatment Outcome, 030220 oncology & carcinogenesis, Multivariate Analysis, 030211 gastroenterology & hepatology, Original Article, Female, business, Colorectal Neoplasms

الوصف: BACKGROUND/AIMS We aimed to investigate the factors associated with piecemeal resection of colorectal neoplasia (CRN), in spite of endoscopic submucosal dissection (ESD). MATERIALS AND METHODS We analyzed the retrospective data for colorectal ESD cases from January 2005 to April 2014. We also reviewed the piecemeal endoscopic mucosal resection (EMR) for CRNs ≥20 mm, performed over the same period. RESULTS En bloc resection was possible in 648 (85.7%) of 756 lesions in 740 patients. Multivariate analysis showed that hybrid ESD (odds ratio (OR), 29.07; 95% confidence interval (CI), 15.46-54.65; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016a22e07078958e2b2781b5b2bdeb74Test
https://europepmc.org/articles/PMC6284627Test/

المؤلفون: Sung Wook Hwang, Dong-Hoon Yang, Seohyun Lee, Suk-Kyun Yang, Jeong Sik Byeon, Jihun Kim, Jung-Ho Bae, Sang Hyoung Park, Seung-Jae Myung, Byong Duk Ye, Jae Seung Soh

المصدر: International journal of colorectal disease. 33(6)

مصطلحات موضوعية: Male, medicine.medical_specialty, Endoscopic Mucosal Resection, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, Humans, R0 resection, Procedure time, Demography, medicine.diagnostic_test, Tumor size, business.industry, Gastroenterology, Margins of Excision, Endoscopic submucosal dissection, Hepatology, Middle Aged, Lateral margin, Endoscopy, Treatment Outcome, 030220 oncology & carcinogenesis, Multivariate Analysis, 030211 gastroenterology & hepatology, Female, Radiology, Neoplasm Recurrence, Local, business, Colorectal Neoplasms, Follow-Up Studies

الوصف: We aimed to evaluate the recurrence rate of colorectal neoplasia showing histologic lateral margin involvement after en bloc endoscopic submucosal dissection (ESD). We reviewed 527 colorectal lesions that were removed by en bloc ESD from 2005 to 2013 and followed by endoscopy. Based on the postprocedural pathologic reports, the lesions were categorized as follows: lesions with clear deep and positive lateral margins (n = 63) and lesions with R0 resection (n = 299). The tumor size was 45.7 ± 21.1 mm in the lateral margin-positive group and 30.6 ± 15.1 in the R0 group (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afbef83adda51e0610830cd8e257906Test
https://pubmed.ncbi.nlm.nih.gov/29532207Test

المؤلفون: Jae Yeon Lee, Byong Duk Ye, Jeong Sik Byeon, Ho-Su Lee, Suk-Kyun Yang, Seung-Jae Myung, Sang Hyoung Park, Jae Seung Soh, Kyung-Jo Kim, Jung-Ho Bae, Dong-Hoon Yang, Hyo Jeong Lee, Seohyun Lee, Jin-Ho Kim

المصدر: Surgical Endoscopy. 30:1619-1628

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Severe fibrosis, Complete resection, Lesion, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Intestinal Mucosa, Aged, Retrospective Studies, Aged, 80 and over, Tumor size, business.industry, Dissection, En bloc resection, Endoscopy, Endoscopic submucosal dissection, Middle Aged, Hepatology, Surgery, Treatment Outcome, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, medicine.symptom, Colorectal Neoplasms, business, Abdominal surgery

الوصف: The therapeutic outcome of endoscopic submucosal dissection (ESD) for large protruding tumors has not yet been evaluated. We aimed to compare the outcomes of ESD in protruding tumors with those of laterally spreading tumors (LSTs). Endoscopic submucosal dissection was attempted in 218 patients with 220 colorectal tumors ≥30 mm in diameter (67, protruding tumors; 153, LSTs) from July 2007 to June 2014. We retrospectively reviewed patient medical records, therapeutic outcomes, and procedure-related adverse events. This study defined lesions with a height of 10 mm or more as protruding tumors and those with a height under 10 mm as LSTs. The mean lesion diameter, height, and volume were 43.8, 9.5 mm, and 13.6 cm3, respectively. The mean procedure time was 75.5 min. Deep submucosal cancer was more frequent in protruding tumors than in LSTs (11.9 vs. 2.6 %, P = 0.005). Severe fibrosis was more common in protruding tumors than in LSTs (19.4 vs. 3.9 %, P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3788496d0ed5bb9bb9f9946c87cbe0Test
https://doi.org/10.1007/s00464-015-4392-6Test

المؤلفون: Sang Hyoung Park, Ho-Su Lee, Jeong Sik Byeon, Dong-Hoon Yang, Soon Man Yoon, Jin-Ho Kim, Hyo Jeong Lee, Dong Uk Kang, Seung-Jae Myung, Y.J. Choi, Byong Duk Ye, Suk-Kyun Yang, Kyung-Jo Kim

المصدر: Gut and Liver

مصطلحات موضوعية: Male, Abdominal pain, medicine.medical_specialty, Endoscopic Mucosal Resection, Colon, medicine.medical_treatment, Perforation (oil well), Colonoscopy, Endoscopic mucosal resection, Colonic Diseases, 03 medical and health sciences, 0302 clinical medicine, Intestinal mucosa, Humans, Medicine, Intestinal Mucosa, Intraoperative Complications, Outcome, Retrospective Studies, Perforation, Hepatology, medicine.diagnostic_test, business.industry, Medical record, Gastroenterology, Retrospective cohort study, Clipping (medicine), Middle Aged, Endoscopic submucosal dissection, Prognosis, Surgery, C-Reactive Protein, Intestinal Perforation, 030220 oncology & carcinogenesis, Original Article, Female, 030211 gastroenterology & hepatology, medicine.symptom, Colorectal Neoplasms, business

الوصف: Background/Aims: Although colorectal endoscopic submucosal dissection (ESD)-related perforation is not uncommon, the factors affecting clinical outcomes after perforation have not been investigated. This study was designed to investigate the factors influencing the clinical course of ESD-related colon perforation. Methods: Forty-three patients with colorectal ESD-related perforation were evaluated. The perforations were classified as endoscopic or radiologic perforations. The patients’ medical records and endoscopic pictures were analyzed. Results: The clinical outcomes were assessed by the duration of nil per os, intravenous antibiotics administration, and hospital stays, which were 2.7±1.5, 4.9±2.3, and 5.1±2.3 days, respectively. Multivariate analyses revealed that a larger tumor size, ESD failure, specific endoscopists, and abdominal pain were independently related to a poorer outcome. The time between perforation and clipping was 15.8±25.4 minutes in the endoscopic perforation group. The multivariate analysis of this group indicated that delayed clipping, specific endoscopists, and abdominal pain were independently associated with poorer outcomes. Conclusions: Tumor size, ESD failure, abdominal pain, and the endoscopist were factors that affected the clinical outcomes of patients with colorectal ESD-related perforation. The time between the perforation and clipping was an additional factor influencing the clinical course of endoscopic perforation. Decreasing this time period may improve outcomes. (Gut Liver 2016;10:420-428)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3537b5b5eb868e35bac485f295d684c8Test
https://doi.org/10.5009/gnl15252Test

المؤلفون: Yangsoon Park, Sang Hyoung Park, Kyung-Jo Kim, Seung-Jae Myung, Jeong-Sik Byeon, Dong-Hoon Yang, Byong Duk Ye, Suk-Kyun Yang

المصدر: Gastrointestinal endoscopy. 83(5)

مصطلحات موضوعية: medicine.medical_specialty, Neoplasm, Residual, Endoscopic Mucosal Resection, health care facilities, manpower, and services, Operative Time, Blood Loss, Surgical, Endoscopic mucosal resection, Neuroendocrine tumors, digestive system, behavioral disciplines and activities, Complete resection, 03 medical and health sciences, 0302 clinical medicine, Intestinal mucosa, health services administration, Medicine, Effective treatment, Humans, Radiology, Nuclear Medicine and imaging, Intestinal Mucosa, health care economics and organizations, business.industry, Rectal Neoplasms, Incidence (epidemiology), Dissection, Gastroenterology, Endoscopic submucosal dissection, medicine.disease, Surgery, Neuroendocrine Tumors, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business, Follow-Up Studies

الوصف: Background and Aims The incidence of rectal neuroendocrine tumors (NETs) is increasing, and most small rectal NETs can be treated endoscopically. Cap-assisted EMR (EMR-C) was suggested as an effective treatment for rectal NETs in a few studies. We aimed to compare the outcomes of conventional EMR, EMR-C, and endoscopic submucosal dissection (ESD) for the treatment of rectal NETs. Methods A total of 138 rectal NETs were treated endoscopically by a single endoscopist at Asan Medical Center. We analyzed 122 rectal NETs that had been removed by using EMR (n = 56), EMR-C (n = 34), or ESD (n = 32). Results The histologic complete resection rate was higher in the EMR-C group than in the EMR group (94.1% vs 76.8%, P = .032). Intraprocedural bleeding tended to be more frequent in the EMR-C group than in the EMR group (8.8% vs 0%, P = .051). No differences in the rates of adverse events or histologic complete resections were observed between the EMR-C group and the ESD group for 6-mm to 8-mm NETs; however, the procedure time was significantly shorter in the EMR-C group (3.9 ± 1.1 minutes) than in the ESD group (19.0 ± 12.1 minutes) ( P Conclusions EMR-C is the preferable technique for endoscopic resection of small rectal NETs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92d1e5730501f2f7aaa5ee55b161e41Test
https://pubmed.ncbi.nlm.nih.gov/26460225Test