المؤلفون: Sigrid Sandner, Catherine J Pachuk, Etem Caliskan, Maximilian Y. Emmert, Thomas Aschacher, Milan Milojevic

المساهمون: University of Zurich, Sandner, Sigrid E, Cardiothoracic Surgery

المصدر: Minerva Cardioangiologica, 68(5), 480-488. Edizioni Minerva Medica

مصطلحات موضوعية: medicine.medical_specialty, Bypass grafting, Saphenous vein graft, Vein graft, 610 Medicine & health, 030204 cardiovascular system & hematology, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 0302 clinical medicine, Preservation solutions, Humans, Medicine, Saphenous Vein, 030212 general & internal medicine, Coronary Artery Bypass, Vascular Patency, business.industry, Cabg surgery, 11359 Institute for Regenerative Medicine (IREM), Blood Vessel Prosthesis, Surgery, Vascular endothelium, Functional integrity, surgical procedures, operative, medicine.anatomical_structure, cardiovascular system, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Artery

الوصف: The saphenous vein graft (SVG) remains the most commonly used conduit in coronary artery bypass grafting (CABG). In light of this further research must be aimed at the development of strategies to optimize SVG patency and thereby improve both short- and long-term outcomes of CABG surgery. SVG patency in large part depends on the protection of the structural and functional integrity of the vascular endothelium at the time of conduit harvesting, including optimal storage conditions to prevent endothelial damage. This review provides an overview of currently available storage and preservation solutions, including novel endothelial damage inhibitors, and their role in mitigating endothelial damage and vein graft failure.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f58d5e1000408a0f0804d0b935ec508Test
https://doi.org/10.23736/s0026-4725.20.05234-2Test

المؤلفون: Stephan Jacobs, Ravi De Silva, Matthias Thielmann, Sunil K. Ohri, Mohamad N. Bittar, Rajesh K. Kharbanda, Ivar Friedrich, Amal Bose, George Krasopoulos, Alexandros Paraforos, Daniel Wendt, Marius Berman, Oliver J. Liakopoulos, Cha Rajakaruna, Thomas Schachner, Thomas R. Gehrig, Joseph Zacharias, Umberto Benedetto, Philipp Angleitner, Yulia Gavrilov, Nikolaos Bonaros, Yeong-Hoon Choi, Sigrid Sandner, Terrence John Donovan, David P. Taggart, Gil Bolotin, Keith M. Channon, Hunaid A. Vohra, Leonid Ladyshenskij, Alexander Lipey

المساهمون: InVESTigators, Benedetto, Umberto (Beitragende*r), Vohra, Hunaid (Beitragende*r), Bittar, Mohamad Nidal (Beitragende*r), Bose, Amal (Beitragende*r), Berman, Marius (Beitragende*r), Kharbanda, Rajesh (Beitragende*r), Paraforos, Alexandros (Beitragende*r), Ladyshenskij, Leonid (Beitragende*r), Bonaros, Nikolaos (Beitragende*r), Schachner, Thomas (Beitragende*r), Sandner, Sigrid (Beitragende*r), Angleitner, Philipp (Beitragende*r), Bolotin, Gil (Beitragende*r), Jacobs, Stephan (Beitragende*r), Thielmann, Matthias Klaus (Beitragende*r), Wendt, Daniel (Beitragende*r), Choi, Yeong-Hoon (Beitragende*r), Liakopoulos, Oliver (Beitragende*r), Ohri, Sunil (Beitragende*r), Lipey, Alexander (Beitragende*r)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Intimal hyperplasia, medicine.medical_treatment, Medizin, Coronary Artery Disease, Internal thoracic artery, 030204 cardiovascular system & hematology, Coronary Angiography, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine.artery, Intravascular ultrasound, Humans, Medicine, Saphenous Vein, Coronary Artery Bypass, Vascular Patency, Computed tomography angiography, Hyperplasia, medicine.diagnostic_test, business.industry, Stent, medicine.disease, Surgery, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, 030228 respiratory system, Angiography, Disease Progression, Stents, Cardiology and Cardiovascular Medicine, business, Artery

الوصف: Objectives Little data exist regarding the potential of external stents to mitigate long-term disease progression in saphenous vein grafts. We investigated the effect of external stents on the progression of saphenous vein graft disease. Methods A total of 184 patients undergoing isolated coronary artery bypass grafting, using an internal thoracic artery graft and at least 2 additional saphenous vein grafts, were enrolled in 14 European centers. One saphenous vein graft was randomized to an external stent, and 1 nonstented saphenous vein graft served as the control. The primary end point was the saphenous vein graft Fitzgibbon patency scale assessed by angiography, and the secondary end point was saphenous vein graft intimal hyperplasia assessed by intravascular ultrasound in a prespecified subgroup at 2 years. Results Angiography was completed in 128 patients and intravascular ultrasound in the entire prespecified cohort (n = 51) at 2 years. Overall patency rates were similar between stented and nonstented saphenous vein grafts (78.3% vs 82.2%, P = .43). However, the Fitzgibbon patency scale was significantly improved in stented versus nonstented saphenous vein grafts, with Fitzgibbon patency scale I, II, and III rates of 66.7% versus 54.9%, 27.8% versus 34.3%, and 5.5% versus 10.8%, respectively (odds ratio, 2.02; P = .03). Fitzgibbon patency scale was inversely related to saphenous vein graft minimal lumen diameter, with Fitzgibbon patency scale I, II, and III saphenous vein grafts having an average minimal lumen diameter of 2.62 mm, 1.98 mm, and 1.32 mm, respectively (P < .05). Externally stented saphenous vein grafts also showed significant reductions in mean intimal hyperplasia area (22.5%; P < .001) and thickness (23.5%; P < .001). Conclusions Two years after coronary artery bypass grafting, external stenting improves Fitzgibbon patency scales of saphenous vein grafts and significantly reduces intimal hyperplasia area and thickness. Whether this will eventually lead to improved long-term patency is still unknown.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d0f111006319341743575a0031db62Test
https://ora.ox.ac.uk/objects/uuid:cc37fff7-fb18-4677-9915-24e6ba021aafTest