نتائج البحث - "Glucagon-Like Peptide-1 Receptor"

1

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4

المؤلفون: George G. Holz, Sarah A. Doebley, Ian R. Sweet, Varun Kamat, Tito Borner, Robert P. Doyle, MacKenzie L. Swanson, Matthew R. Hayes, Bart C. De Jonghe, Ian C. Tinsley, Oleg G. Chepurny

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Agonist, Models, Molecular, endocrine system, medicine.drug_class, Central nervous system, Pharmacology, 01 natural sciences, Article, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Islets of Langerhans, In vivo, Drug Discovery, Insulin Secretion, medicine, Animals, Humans, Hypoglycemic Agents, Cells, Cultured, 030304 developmental biology, 0303 health sciences, geography, geography.geographical_feature_category, HEK 293 cells, Corrin, digestive, oral, and skin physiology, Islet, Small molecule, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, HEK293 Cells, chemistry, Molecular Medicine, Corrinoids, Exenatide, Conjugate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b061aa87a91447a8aee1a09b2bc098ecTest
http://europepmc.org/articles/PMC8279408Test

2

Glucagon‐Like Peptide‐1 Receptor Signaling in the Ventral Tegmental Area Reduces Alcohol Self‐Administration in Male Rats

المؤلفون: Tiarani N Dixon, Gavan P. McNally, Zhi Yi Ong

المصدر: Alcoholism: Clinical and Experimental Research. 44:2118-2129

مصطلحات موضوعية: Male, medicine.medical_specialty, Alcohol Drinking, 030508 substance abuse, Medicine (miscellaneous), Alcohol, Motor Activity, Nose poke, Toxicology, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Glucagon-Like Peptide 1, Internal medicine, Male rats, medicine, Animals, Rats, Long-Evans, business.industry, Ventral Tegmental Area, Receptor signaling, Extinction (psychology), Glucagon-like peptide-1, Rats, Ventral tegmental area, Psychiatry and Mental health, Endocrinology, medicine.anatomical_structure, chemistry, Exenatide, 0305 other medical science, Self-administration, business, 030217 neurology & neurosurgery, Alcohol Deterrents, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b7922facab83709658a5187c002153Test
https://doi.org/10.1111/acer.14437Test

3

Exendin‐4, a GLP‐1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia–reperfusion injury

المؤلفون: Xiangmei Kong, Jihong Wu, Xinghuai Sun, Huan Xu, Fang-Yuan Hu, Ruyi Zhai

المصدر: British Journal of Pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa0852506092c00f688a88f4c3a760cTest
https://doi.org/10.1111/bph.15059Test

4

The Anti-Inflammatory Effects of Glucagon-Like Peptide Receptor Agonist Lixisenatide on the Retinal Nuclear and Nerve Fiber Layers in an Animal Model of Early Type 2 Diabetes

المؤلفون: Yeon Woong Chung, Ji Young Lee, Jin A Choi, Jae-Hyung Lee, Seung Hyun Ko, Hyun Hee Ju, Ye-Jee Lee, Dong Hyun Jee

المصدر: The American Journal of Pathology. 190:1080-1094

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.medical_specialty, genetic structures, medicine.drug_class, Anti-Inflammatory Agents, Nerve fiber, Glucagon-Like Peptide-1 Receptor, Retina, Diabetes Mellitus, Experimental, Pathology and Forensic Medicine, Mice, 03 medical and health sciences, Lixisenatide, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Animals, Hypoglycemic Agents, Medicine, Diabetic Retinopathy, Glial fibrillary acidic protein, biology, business.industry, Diabetic retinopathy, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Inner nuclear layer, 030221 ophthalmology & optometry, Optic nerve, biology.protein, sense organs, Peptides, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d7a6de97da4c20751f8f596a2d2bfcTest
https://doi.org/10.1016/j.ajpath.2020.01.011Test

5

Loureirin B activates GLP-1R and promotes insulin secretion in Ins-1 cells

المؤلفون: Qin Chen, Yanting Ding, Sijing Xia, Han Zhang, Bing Niu

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, Agonist, endocrine system, insulin, natural product, medicine.drug_class, Cell Survival, medicine.medical_treatment, Cell, Blotting, Western, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Insulin-Secreting Cells, Insulin Secretion, medicine, Animals, Hypoglycemic Agents, Surface plasmon resonance, Insulin secretion, Receptor, agonist, Biological Products, Natural product, glucagon‐like peptide‐1 receptor, Insulin, digestive, oral, and skin physiology, Cell Biology, Original Articles, Prodrug, Cell biology, Rats, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, hormones, hormone substitutes, and hormone antagonists, Resins, Plant, anti‐diabetic drugs

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902f98850009ef07490e23fea675e83bTest
https://pubmed.ncbi.nlm.nih.gov/33300675Test

6

GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential

المؤلفون: Zhengfang Chen, Xueying Zheng, Jianping Weng, Peter J. Little, Xiaoxuan Ma, Suowen Xu, Zhenghong Liu, Sihui Luo, Danielle Kamato, Amirhossein Sahebka, Iqra Ilyas

المصدر: International Journal of Biological Sciences

مصطلحات موضوعية: Cell type, Review, MACE, Pharmacology, Hypoglycemia, Applied Microbiology and Biotechnology, GLP-1RAs, Glucagon-Like Peptide-1 Receptor, CVOT, 03 medical and health sciences, chemistry.chemical_compound, Diabetes mellitus, Medicine, Humans, Hypoglycemic Agents, Endothelial dysfunction, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Glucagon-like peptide 1 receptor, 030304 developmental biology, 0303 health sciences, diabetes, business.industry, Monocyte, Type 2 Diabetes Mellitus, Cell Biology, medicine.disease, Atherosclerosis, CVD, medicine.anatomical_structure, chemistry, Diabetes Mellitus, Type 2, Cardiovascular Diseases, glycemic control, Glycated hemoglobin, business, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498851ee36efc54996ebab6eca8ee3d1Test
https://pubmed.ncbi.nlm.nih.gov/34131405Test

7

Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target?

المؤلفون: Yingzhe Wang, Qiang Dong, Xun Wang, Mei Cui, Min Guo, Yanan Xie, Hongyan Ding

المصدر: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Journal of Neuroinflammation

مصطلحات موضوعية: Male, 0301 basic medicine, Glycosylation, Caveolin 1, Matrix metalloproteinase, Pharmacology, lcsh:RC346-429, chemistry.chemical_compound, 0302 clinical medicine, Glycation, RNA, Small Interfering, Cells, Cultured, Blood-brain barrier, Ischemic stroke, Chemistry, General Neuroscience, Diabetes, Brain, Infarction, Middle Cerebral Artery, Tunicamycin, medicine.anatomical_structure, Matrix Metalloproteinase 9, Neurology, Tissue Plasminogen Activator, CD147, Matrix Metalloproteinase 2, Glucagon-like peptide-1 receptor agonist, Collagen Type IV, Agonist, Endothelium, medicine.drug_class, Immunology, Hemorrhage, Blood–brain barrier, Diabetes Mellitus, Experimental, 03 medical and health sciences, Cellular and Molecular Neuroscience, Downregulation and upregulation, Occludin, Glial Fibrillary Acidic Protein, medicine, Animals, Rats, Wistar, lcsh:Neurology. Diseases of the nervous system, Research, Endothelial Cells, Rats, carbohydrates (lipids), Disease Models, Animal, 030104 developmental biology, Astrocytes, Reperfusion, Basigin, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2198d7fefc2798c2fa9bb0e68c578108Test
http://link.springer.com/article/10.1186/s12974-019-1460-1Test

8

Exenatide modulates expression of metalloproteinases and their tissue inhibitors in TNF-α stimulated human retinal pigment epithelial cells

المؤلفون: Agnieszka Kłych-Ratuszny, Mohammad Reza F. Aghdam, Mariola Dorecka, Wojciech Garczorz, Enrique Gallego-Colon, Michał Woźniak, Tomasz Francuz, Krzysztof Siemianowicz, Agnieszka Kosowska

المصدر: Pharmacological Reports. 71:175-182

مصطلحات موضوعية: Angiogenesis, Incretin, Inflammation, Retinal Pigment Epithelium, Pharmacology, Matrix metalloproteinase, Incretins, Glucagon-Like Peptide-1 Receptor, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Hypoglycemic Agents, Collagenases, Phosphorylation, Tissue Inhibitor of Metalloproteinase-3, Tissue Inhibitor of Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-1, Retinal pigment epithelium, Tumor Necrosis Factor-alpha, Epithelial Cells, Tissue Inhibitor of Metalloproteinases, Retinal, General Medicine, Extracellular Matrix, medicine.anatomical_structure, Matrix Metalloproteinase 9, chemistry, 030220 oncology & carcinogenesis, Exenatide, Matrix Metalloproteinase 2, Tumor necrosis factor alpha, Matrix Metalloproteinase 1, medicine.symptom, Proto-Oncogene Proteins c-akt, 030217 neurology & neurosurgery, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15df44a95ce939e306f989b43177aac2Test
https://doi.org/10.1016/j.pharep.2018.10.003Test

9

Glucagon-like peptide-1 (GLP-1) action in the mouse area postrema neurons

المؤلفون: Masahiro Kawatani, Yuichiro Yamada, Masahito Kawatani

المصدر: Peptides. 107:68-74

مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Patch-Clamp Techniques, Physiology, Incretin, Peptide hormone, Biochemistry, Glucagon-Like Peptide-1 Receptor, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, Internal medicine, medicine, Animals, Receptor, Circumventricular organs, Mice, Knockout, Neurons, Chemistry, digestive, oral, and skin physiology, Area postrema, Glucagon-like peptide-1, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Area Postrema, Tetrodotoxin, Female, Nucleus, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f237425d10f02b5d72f616b98e5542Test
https://doi.org/10.1016/j.peptides.2018.07.010Test

10

Glucose‐induced cAMP elevation in β‐cells involves amplification of constitutive and glucagon‐activated GLP‐1 receptor signalling

المؤلفون: Parvin Ahooghalandari, Yunjian Xu, Anders Tengholm, Hongyan Shuai

المصدر: Acta Physiologica (Oxford, England)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, insulin secretion, IBMX, Physiology, medicine.medical_treatment, Cell- och molekylärbiologi, 030204 cardiovascular system & hematology, Glucagon, Exocytosis, Glucagon-Like Peptide-1 Receptor, Adenylyl cyclase, 03 medical and health sciences, chemistry.chemical_compound, Islets of Langerhans, Mice, 0302 clinical medicine, Internal medicine, medicine, Regular Paper, Cyclic AMP, Animals, Humans, Insulin, Receptor, Glucagon-like peptide 1 receptor, pancreatic islets, glucagon‐like peptide‐1, Pancreatic islets, Metabolism and Nutritional Physiology, exendin‐(9‐39), 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Glucose, chemistry, glucagon, glucagon-like peptide-1, Calcium, adenylyl cyclase, exendin-(9-39), Cell and Molecular Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52920609b98f24940aebc69c63a069e8Test
http://europepmc.org/articles/PMC8047901Test

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