Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods
| العنوان: | Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods |
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| المؤلفون: | Mojtaba Bandarabadi, Heidemarie Gast, Christian Rummel, Claudio Bassetti, Antoine Adamantidis, Kaspar Schindler, Frederic Zubler |
| المصدر: | Frontiers in Neurology Bandarabadi, Mojtaba; Gast, Heidemarie; Rummel, Christian; Bassetti, Claudio; Adamantidis, Antoine; Schindler, Kaspar; Zubler, Frédéric (2019). Assessing Epileptogenicity Using Phase-Locked High Frequency Oscillations: A Systematic Comparison of Methods (In Press). Frontiers in neurology, 10 Frontiers Media S.A. 10.3389/fneur.2019.01132 <http://dx.doi.org/10.3389/fneur.2019.01132Test> Frontiers in Neurology, Vol 10 (2019) |
| بيانات النشر: | Frontiers Media S.A., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Modulation index, Phase (waves), 610 Medicine & health, cross-frequency coupling, Electroencephalography, high frequency oscillations, lcsh:RC346-429, 050105 experimental psychology, Algorithm Selection, Resection, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Mean vector, 0501 psychology and cognitive sciences, Ictal, lcsh:Neurology. Diseases of the nervous system, Original Research, medicine.diagnostic_test, business.industry, 05 social sciences, Significant difference, presurgical evaluation, Neurology, Cardiology, Neurology (clinical), business, epileptogenic zone, 030217 neurology & neurosurgery, electroencephalography |
| الوصف: | High frequency oscillations (HFOs) are traditional biomarkers to identify the epileptogenic tissue during presurgical evaluation in pharmacoresistant epileptic patients. Recently, the resection of brain tissue exhibiting coupling between the amplitude of HFOs and the phase of low frequencies demonstrated a more favorable surgical outcome. Here we compare the predictive value of ictal HFOs and four methods for quantifying the ictal phase-amplitude coupling, namely mean vector length, phase-locked high gamma, phase locking value, and modulation index (MI). We analyzed 32 seizures from 16 patients to identify the channels that exhibit HFOs and phase-locked HFOs during seizures. We compared the resection ratio, defined as the percentage of channels exhibiting coupling located in the resected tissue, with the postsurgical outcome. We found that the MI is the only method to show a significant difference between the resection ratios of patients with good and poor outcomes. We further show that the whole seizure, not only the onset, is critical to assess epileptogenicity using the phase-locked HFOs. We postulate that the superiority of MI stems from its capacity to assess coupling of discrete HFO events and its independence from the HFO power. These results confirm that quantitative analysis of HFOs can boost presurgical evaluation and indicate the paramount importance of algorithm selection for clinical applications. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.7892/boris.134861 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182d2dbd6f0e424671dc2408daf0b181Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....182d2dbd6f0e424671dc2408daf0b181 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.7892/boris.134861 |
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