Insulin and Glucagon:Partners for Life
| العنوان: | Insulin and Glucagon:Partners for Life |
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| المؤلفون: | Jesper Gromada, Hai Yan, Pedro Luis Herrera, Timothy J. Kieffer, Nicolas Damond, Kyle W. Sloop, William L. Holland, Young H Lee, Jens J. Holst, Roger H Unger |
| المصدر: | Holst, J J, Holland, W, Gromada, J, Lee, Y, Unger, R H, Yan, H, Sloop, K W, Kieffer, T J, Damond, N & Herrera, P L 2017, ' Insulin and Glucagon : Partners for Life ', Endocrinology, vol. 158, no. 4, pp. 696-701 . https://doi.org/10.1210/en.2016-1748Test Endocrinology, Vol. 158, No 4 (2017) pp. 696-701 Endocrinology |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Glucose, endocrine system, medicine.medical_specialty, endocrine system diseases, Diabetes, Pancreatic and Gastrointestinal Hormones, medicine.medical_treatment, 030209 endocrinology & metabolism, Review, Glucagon, Diabetes Mellitus, Experimental, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, Diabetes Mellitus, Journal Article, Medicine, Animals, Humans, Hypoglycemic Agents, Insulin, ddc:576.5, business.industry, Basal insulin, digestive, oral, and skin physiology, nutritional and metabolic diseases, Mini-review, medicine.disease, Streptozotocin, Blockade, 030104 developmental biology, Beta cell, business, Glucagon receptor, hormones, hormone substitutes, and hormone antagonists, medicine.drug |
| الوصف: | Is glucagon essential for the hyperglycemia in insulin deficiency, as suggested by experimental glucagon antagonism? No, sufficient levels of basal insulin must be present to prevent hyperglycemia. In August 2016, several leaders in glucagon biology gathered for the European Association for the Study of Diabetes Hagedorn Workshop in Oxford, England. A key point of discussion focused on the need for basal insulin to allow for the therapeutic benefit of glucagon blockade in the treatment of diabetes. Among the most enlightening experimental results presented were findings from studies in which glucagon receptor–deficient mice were administered streptozotocin to destroy pancreatic β cells or had undergone diphtheria toxin–induced β cell ablation. This article summarizes key features of the discussion as a consensus was reached. Agents that antagonize glucagon may be of great benefit for the treatment of diabetes; however, sufficient levels of basal insulin are required for their therapeutic efficacy. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0013-7227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044f4832cbead856329042b36955557Test https://curis.ku.dk/ws/files/188521763/en.2016_1748.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0044f4832cbead856329042b36955557 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00137227 |
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