Epicardial adipose tissue characteristics, obesity and clinical outcomes in COVID-19: A post-hoc analysis of a prospective cohort study
| العنوان: | Epicardial adipose tissue characteristics, obesity and clinical outcomes in COVID-19: A post-hoc analysis of a prospective cohort study |
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| المؤلفون: | Riccardo Leone, Alberto Zangrillo, Valeria Nicoletti, Luigi di Filippo, Guglielmo Gallone, Fabio Ciceri, Francesco De Cobelli, Paolo G. Camici, Antonio Secchi, Antonella Castagna, Rebecca De Lorenzo, Annalisa Ruggeri, Emanuele Bosi, Anna Palmisano, Giovanni Landoni, Patrizia Rovere-Querini, Moreno Tresoldi, Antonio Esposito, Caterina Conte, Davide Vignale |
| المساهمون: | Conte, Caterina, Esposito, Antonio, De Lorenzo, Rebecca, Di Filippo, Luigi, Palmisano, Anna, Vignale, Davide, Leone, Riccardo, Nicoletti, Valeria, Ruggeri, Annalisa, Gallone, Guglielmo, Secchi, Antonio, Bosi, Emanuele, Tresoldi, Moreno, Castagna, Antonella, Landoni, Giovanni, Zangrillo, Alberto, De Cobelli, Francesco, Ciceri, Fabio, Camici, Paolo, Rovere-Querini, Patrizia |
| المصدر: | Nutrition, Metabolism, and Cardiovascular Diseases |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030204 cardiovascular system & hematology, Overweight, law.invention, 0302 clinical medicine, Risk Factors, law, Medicine, Visceral fat, Hospital Mortality, Prospective Studies, Prospective cohort study, Adiposity, Nutrition and Dietetics, Middle Aged, Prognosis, Intensive care unit, Cardiac injury, Italy, Predictive value of tests, Female, Radiography, Thoracic, medicine.symptom, Cardiology and Cardiovascular Medicine, Pericardium, medicine.medical_specialty, 030209 endocrinology & metabolism, Intra-Abdominal Fat, Risk Assessment, Article, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, Diabetes mellitus, Epicardial adipose tissue, Post-hoc analysis, Humans, Obesity, Aged, Inflammation, SARS-CoV-2, business.industry, Proportional hazards model, COVID-19, medicine.disease, Tomography, X-Ray Computed, business |
| الوصف: | Background and aims Obesity-related cardiometabolic risk factors associate with COVID-19 severity and outcomes. Epicardial adipose tissue (EAT) is associated with cardiometabolic disturbances, is a source of proinflammatory cytokines and a marker of visceral adiposity. We investigated the relation between EAT characteristics and outcomes in COVID-19 patients. Methods and results This post-hoc analysis of a large prospective investigation included all adult patients (≥18 years) admitted to San Raffaele University Hospital in Milan, Italy, from February 25th to April 19th, 2020 with confirmed SARS-CoV-2 infection who underwent a chest computed tomography (CT) scan for COVID-19 pneumonia and had anthropometric data available for analyses. EAT volume and attenuation (EAT-At, a marker of EAT inflammation) were measured on CT scan. Primary outcome was critical illness, defined as admission to intensive care unit (ICU), invasive ventilation or death. Cox regression and regression tree analyses were used to assess the relationship between clinical variables, EAT characteristics and critical illness. One-hundred and ninety-two patients were included (median [25th-75th percentile] age 60 years [53-70], 76% men). Co-morbidities included overweight/obesity (70%), arterial hypertension (40%), and diabetes (16%). At multivariable Cox regression analysis, EAT-At (HR 1.12 [1.04-1.21]) independently predicted critical illness, while increasing PaO2/FiO2 was protective (HR 0.996 [95% CI 0.993; 1.00]). CRP, plasma glucose on admission, EAT-At and PaO2/FiO2 identified five risk groups that significantly differed with respect to time to death or admission to ICU (log-rank p Graphical abstract Image 1 |
| تدمد: | 0939-4753 0431-8366 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f4ae73fb7c092fbd62a7432a3368d4Test https://doi.org/10.1016/j.numecd.2021.04.020Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24f4ae73fb7c092fbd62a7432a3368d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09394753 04318366 |
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