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المؤلفون: Rita Mendes, Catarina Brito, Megan C. Cox, Inês A. Isidro, Kathleen Halwachs, Fernanda Silva, Julie J Purkal, Adelyn L Zelaya-Lazo, Ana Félix, Erwin R. Boghaert, Teresa F. Mendes
المساهمون: Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Cancer microenvironment, Science, Drug development, Antineoplastic Agents, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Lactate dehydrogenase, Cell Line, Tumor, Neoplasms, Spheroids, Cellular, Drug Discovery, Tumor Cells, Cultured, Medicine, Animals, Humans, General, Cancer models, 030304 developmental biology, 0303 health sciences, Multidisciplinary, L-Lactate Dehydrogenase, business.industry, Culture growth, 3. Good health, Clinical trial, chemistry, 030220 oncology & carcinogenesis, Cancer research, Drug Screening Assays, Antitumor, business, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8ac81b3c771941eb41563f083c9b56Test
https://doaj.org/article/6ba6021cf4734f4ebc89722a5ae55c02Test -
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المؤلفون: Philip L. Lorenzi, Wuhao Lu, Meng Cui, Xiangdong Le, Yunyun Chen, Anastasios Maniakas, Lin Tan, Vlad C. Sandulache, Keith A. Michel, Stephen Y. Lai, Nagireddy Putluri, Abdallah S.R. Mohamed, Joshua S. Niedzielski, James A. Bankson, Collin J. Harlan, Ying C. Henderson
المصدر: Br J Cancer
مصطلحات موضوعية: Cancer Research, Lactate dehydrogenase A, Down-Regulation, Mice, Nude, Context (language use), Gene Expression Regulation, Enzymologic, Article, Small hairpin RNA, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Lactate dehydrogenase, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Metabolomics, Glycolysis, Molecular Targeted Therapy, Enzyme Inhibitors, RNA, Small Interfering, education, education.field_of_study, L-Lactate Dehydrogenase, Squamous Cell Carcinoma of Head and Neck, Chemistry, medicine.disease, Xenograft Model Antitumor Assays, Head and neck squamous-cell carcinoma, Gene Expression Regulation, Neoplastic, Oncology, Head and Neck Neoplasms, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, Feasibility Studies, Female, Reprogramming, Algorithms, Intracellular
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb89361b349a5c507df84525a5db944Test
https://doi.org/10.1038/s41416-021-01297-xTest -
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المؤلفون: Noemí Gómez-Lado, Manuel Macia, Efigenia Arias, Anxo Martinez-Ordoñez, Noemi Eiro, Tomás García-Caballero, Fabio Pereira, Samuel Seoane, Pablo Aguiar, Leandro Avila, Roman Perez-Fernandez, Francisco J. Vizoso
المساهمون: Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Universidade de Santiago de Compostela. Departamento de Ciencias Morfolóxicas, Universidade de Santiago de Compostela. Departamento de Fisioloxía
المصدر: Oncogene
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instnameمصطلحات موضوعية: 0301 basic medicine, Cancer Research, Lactate dehydrogenase A, Mice, Nude, Biology, Transfection, Article, Mice, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, Immune system, Genetics, medicine, Animals, Humans, education, Molecular Biology, Transcription factor, Mice, Inbred BALB C, Gene knockdown, education.field_of_study, L-Lactate Dehydrogenase, Cancer, Cellular Reprogramming, medicine.disease, Mechanisms of disease, 030104 developmental biology, Anaerobic glycolysis, 030220 oncology & carcinogenesis, Cancer cell, Disease Progression, MCF-7 Cells, Cancer research, Heterografts, Transcription Factor Pit-1
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a358d1462b424fffacaaaf3dad9744f0Test
https://doi.org/10.1038/s41388-021-01740-6Test -
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المؤلفون: Kaneez Fatima, Abha Meena, Suaib Luqman, Nusrat Masood, Zahoor Ahmad Wani
المصدر: Journal of Advanced Research
مصطلحات موضوعية: TRIG, Triglyceraldehyde, Skin Neoplasms, Cell, DOXO, Doxorubicin, Hyaluronidase, Pharmacology, NaOH, Sodium hydroxide, Polymerization, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Mice, 0302 clinical medicine, BIL, Bilirubin total & direct, Neomenthol, PEP A, pepstatin A, Cancer biomarker, MEF, Mean erythrocyte fragility, HYAL, Hyaluronidase, PBS, Phosphate buffer saline, CM-H2DCFDA, Chloromethyl derivative of dichloro fluorescin diacetate, HA, Hyaluronic acid, Epidermoid carcinoma, Human epidermoid carcinoma, 030220 oncology & carcinogenesis, RBC, Red blood cell, DMEM, Dulbecco’s minimal essential media, SRB, Sulphorhodamine B, BUN, Blood urea nitrogen, FACS, Fluorescence-Activated Cell Sorting, AKLP, Alkaline phosphatase, Hyaluronoglucosaminidase, NADPH, Nicotinamide adenine dinucleotide phosphate hydrogen, TMPD, N,N,N′,N′-tetramethyl-p-phenylenediamine, Article, 03 medical and health sciences, In vivo, Ehrlich Ascites Carcinoma, BE, Binding energy, Humans, CATD, Cathepsin D, LDH, Lactate dehydrogenase, COX-2, Cyclooxygenase 2, FOX, Ferrous oxidation-xylenol orange, DMSO, Dimethyl sulfoxide, mTOR, Mammalian target of rapamycin, In vitro, Ab/Am, Antibiotic/antimycotic, NRU, Neutral red uptake, EC50, Half maximal effective concentration, 030104 developmental biology, IC50, Half maximal inhibitory concentration, EAC, Ehlrich Ascites Carcinoma, RPMI, Roswell park memorial institute, ROS, Reactive oxygen species, 0301 basic medicine, HDL, High density lipoprotein, TNBS, Trinitrobenzenesulphonic acid, PI3K, Phosphotidyl inositol-3 kinase, URIC, Uric acid, DNA, Deoxyribonucleic acid, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid, Tubulin, OECD, Organization for Economic Co-operation and Development, SGPT, Alanine aminotransferase, LOX-5, Lipoxygenase-5, DFMO, α-difluoro methyl ornithine, Multidisciplinary, WBC, White blood cell, Chemistry, ELISA, enzyme-linked immunosorbent assay, PKB/Akt, Protein kinase B, AA, Arachidonic acid, RNase A, Ribonuclease A, TPR, Total protein, Molecular Docking Simulation, medicine.anatomical_structure, TCA, Tricarboxylic acid, CHOL, Cholesterol, Ki, Inhibitory constant, medicine.drug, ODC, Ornithine decarboxylase, DHFR, Dihydrofolatereductase, BSA, Bovine serum albumin, PDB, Protein Data Bank, medicine, Animals, MMP, Mitochondrial membrane potential, DCFDA, 2′,7′ dichloro fluorescin diacetate, RNA, Ribonucleic acid, RIPA, Radio immune precipitation assay buffer, EDTA, Ethylene diamine tetra acetic acid, IC50, TPA, 12-O-Tetradecanoylphorbol-13-acetate, ComputingMethodologies_COMPUTERGRAPHICS, TRPM8, Transient receptor potential member 8, Cell Proliferation, HDAC, Histone deacetylase, MTX, Methotrexate, OF, Osmotic fragility, PI, Propidium iodide, FDA, Food and Drug Administration, HEK293 Cells, PDT, Podophyllotoxin, Cell culture, NAC, N-acetyl cysteine, SGOT, Aspartate aminotransferase, CRTN, Creatinine, FBS, Fetal bovine serum, PCR, Polymerase chain reaction, Rh123, Rhodamine 123, Ex vivo, IDT, Integrated DNA Technologies
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618e7dc6e2d535e1930d5f8c2bf7d7eTest
https://doi.org/10.1016/j.jare.2021.06.003Test -
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المؤلفون: Yimeng Cui, Yue Cui, Ying Song, Ying Xing, Yaowen Cui, Shi Yan, Li Cai, Fanglin Tian, Xin Wang, Mengru Cao, Xiuwen Lan, Jian Huang, Dexin Jia
المصدر: Cancer Letters. 520:12-25
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Vesicular Transport Proteins, Proto-Oncogene Proteins c-myc, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, In vivo, Carcinoma, Non-Small-Cell Lung, Positron Emission Tomography Computed Tomography, Warburg Effect, Oncologic, Animals, Humans, Glycolysis, Wnt Signaling Pathway, beta Catenin, Cell Proliferation, Gene knockdown, L-Lactate Dehydrogenase, Microarray analysis techniques, Chemistry, Wnt signaling pathway, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 14-3-3 Proteins, Oncology, Gluconeogenesis, A549 Cells, Anaerobic glycolysis, 030220 oncology & carcinogenesis, Catenin, Cancer research, Heterografts, Female
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb4af7d2481ec282960df850bd56d93Test
https://doi.org/10.1016/j.canlet.2021.06.023Test -
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المؤلفون: Bowen Gao, Weidong Zhang, Yanfeng Wu, Huiyong Shen, Yangbai Sun, Fengfeng Li, Mengjun Ma, Sanhong Liu, Yuhang Jiang, Meng Chen
المصدر: Theranostics
مصطلحات موضوعية: 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, Lung Neoplasms, Cell, Mice, Nude, Medicine (miscellaneous), Bone Neoplasms, LDHA, Biology, Metastasis, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Histone demethylation, Cell Movement, In vivo, Cell Line, Tumor, Lactate dehydrogenase, medicine, Animals, Humans, KDM6B, Molecular Targeted Therapy, Precision Medicine, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Osteosarcoma, L-Lactate Dehydrogenase, Cell migration, Benzazepines, Prognosis, medicine.disease, Xenograft Model Antitumor Assays, Up-Regulation, Histone Code, Pyrimidines, Lung metastasis, 030104 developmental biology, medicine.anatomical_structure, Real-time polymerase chain reaction, chemistry, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, H3K27me3 demethylation, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3e18f7ec254eb7663021f8f7473dfaTest
https://doi.org/10.7150/thno.53347Test -
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المؤلفون: Michelle Khai Khun Yap, Jia Jin Hiu
المصدر: International Journal of Biological Macromolecules. 184:776-786
مصطلحات موضوعية: Proteomics, Programmed cell death, Cell Membrane Permeability, Time Factors, Cell Survival, Necroptosis, Breast Neoplasms, Venom, 02 engineering and technology, medicine.disease_cause, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Tandem Mass Spectrometry, Structural Biology, Lactate dehydrogenase, medicine, Animals, Humans, Cobra Neurotoxin Proteins, Molecular Biology, 030304 developmental biology, Elapid Venoms, 0303 health sciences, Dose-Response Relationship, Drug, Toxin, Naja, General Medicine, Metabolism, 021001 nanoscience & nanotechnology, Molecular biology, Gene Expression Regulation, Neoplastic, chemistry, MCF-7, Apoptosis, MCF-7 Cells, Female, 0210 nano-technology, Chromatography, Liquid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb36fa614ee30c276ee69b80e995532bTest
https://doi.org/10.1016/j.ijbiomac.2021.06.145Test -
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المؤلفون: Zhao Cheng, Zhihua Wang, Yi-Fang Yi, Wen-Yong Kuang, Lingli Yuan, Hongling Peng, Guangsen Zhang, Yafei Yin, Yajuan Cui, Fan-Jie Gong, Ruijuan Li, Heng Li, Haiying Zhong, Haizhi Yu
المصدر: Cancer Communications, Vol 40, Iss 10, Pp 501-517 (2020)
Cancer Communicationsمصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, CRISPR/Cas9 gene‐editing, oxamate, T-Lymphocytes, Lactate dehydrogenase A, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Jurkat cells, lcsh:RC254-282, LDHA, Animals, Genetically Modified, Proto-Oncogene Proteins c-myc, Jurkat Cells, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, education, Protein kinase B, GSK3B, Zebrafish, PI3K/AKT/mTOR pathway, Oxamic Acid, education.field_of_study, Gene knockdown, Glycogen Synthase Kinase 3 beta, Kinase, Chemistry, Original Articles, Cell cycle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, T‐cell lymphoblastic leukemia, 030104 developmental biology, Oncology, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, transgenic zebrafish model, Original Article, Female, Lactate Dehydrogenase 5, Proto-Oncogene Proteins c-akt, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a7a0d309db1a672a3721ab79b90911Test
https://doaj.org/article/05c2fa1e4b2c4d5f9ac1b8904efb8186Test -
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المؤلفون: Da-Won Hong, Sung Hee Hong, Tae Woo Kim, Joung Whan Park
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, Cell cycle checkpoint, Lung Neoplasms, Cancer therapy, Apoptosis, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Ligands, Radiation Tolerance, chemistry.chemical_compound, Mice, 0302 clinical medicine, Onium Compounds, Carcinoma, Non-Small-Cell Lung, Adipocytes, Anilides, RNA, Small Interfering, Receptor, Cytotoxicity, Luciferases, Membrane Potential, Mitochondrial, Mice, Inbred BALB C, NADPH oxidase, biology, Cell Death, Chemistry, Caspase 3, Imidazoles, Cell Differentiation, 3T3 Cells, Caspase 9, Tumor Burden, Oncology, 030220 oncology & carcinogenesis, Female, Lung cancer, Signal Transduction, Programmed cell death, Epithelial-Mesenchymal Transition, Mice, Nude, Article, 03 medical and health sciences, Lactate dehydrogenase, Cell Line, Tumor, medicine, Animals, Humans, L-Lactate Dehydrogenase, Cell Cycle Checkpoints, medicine.disease, PPAR gamma, Purines, biology.protein, Cancer research, Thiazolidinediones, Tumor Suppressor Protein p53, Reactive Oxygen Species, Azo Compounds, DNA Damage
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3d84cfb28effda0709cc85c379ee0aTest
http://europepmc.org/articles/PMC7723055Test -
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المصدر: Journal of Ocular Pharmacology and Therapeutics. 37:301-312
مصطلحات موضوعية: Adult, 0301 basic medicine, Cell Survival, Swine, Induced Pluripotent Stem Cells, Apoptosis, Enzyme-Linked Immunosorbent Assay, Biology, Regenerative Medicine, Retina, 03 medical and health sciences, chemistry.chemical_compound, Paracrine signalling, 0302 clinical medicine, Neurotrophic factors, medicine, Animals, Humans, Pharmacology (medical), Nerve Growth Factors, Progenitor cell, Induced pluripotent stem cell, Pharmacology, L-Lactate Dehydrogenase, Stem Cells, Retinal, Immunohistochemistry, Cell biology, Ophthalmology, Neuroprotective Agents, 030104 developmental biology, medicine.anatomical_structure, chemistry, Models, Animal, 030221 ophthalmology & optometry, Female, Hepatocyte growth factor, sense organs, Cell activation, Neuroglia, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619f0c234bf5105fcf94f24854e6eac1Test
https://doi.org/10.1089/jop.2020.0088Test