نتائج البحث - "Lactate dehydrogenase"

1

Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer

المؤلفون: Philip L. Lorenzi, Wuhao Lu, Meng Cui, Xiangdong Le, Yunyun Chen, Anastasios Maniakas, Lin Tan, Vlad C. Sandulache, Keith A. Michel, Stephen Y. Lai, Nagireddy Putluri, Abdallah S.R. Mohamed, Joshua S. Niedzielski, James A. Bankson, Collin J. Harlan, Ying C. Henderson

المصدر: Br J Cancer

مصطلحات موضوعية: Cancer Research, Lactate dehydrogenase A, Down-Regulation, Mice, Nude, Context (language use), Gene Expression Regulation, Enzymologic, Article, Small hairpin RNA, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Lactate dehydrogenase, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Metabolomics, Glycolysis, Molecular Targeted Therapy, Enzyme Inhibitors, RNA, Small Interfering, education, education.field_of_study, L-Lactate Dehydrogenase, Squamous Cell Carcinoma of Head and Neck, Chemistry, medicine.disease, Xenograft Model Antitumor Assays, Head and neck squamous-cell carcinoma, Gene Expression Regulation, Neoplastic, Oncology, Head and Neck Neoplasms, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, Feasibility Studies, Female, Reprogramming, Algorithms, Intracellular

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb89361b349a5c507df84525a5db944Test
https://doi.org/10.1038/s41416-021-01297-xTest

2

A feedback circuit comprising EHD1 and 14-3-3ζ sustains β-catenin/c-Myc-mediated aerobic glycolysis and proliferation in non-small cell lung cancer

المؤلفون: Yimeng Cui, Yue Cui, Ying Song, Ying Xing, Yaowen Cui, Shi Yan, Li Cai, Fanglin Tian, Xin Wang, Mengru Cao, Xiuwen Lan, Jian Huang, Dexin Jia

المصدر: Cancer Letters. 520:12-25

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Vesicular Transport Proteins, Proto-Oncogene Proteins c-myc, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, In vivo, Carcinoma, Non-Small-Cell Lung, Positron Emission Tomography Computed Tomography, Warburg Effect, Oncologic, Animals, Humans, Glycolysis, Wnt Signaling Pathway, beta Catenin, Cell Proliferation, Gene knockdown, L-Lactate Dehydrogenase, Microarray analysis techniques, Chemistry, Wnt signaling pathway, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 14-3-3 Proteins, Oncology, Gluconeogenesis, A549 Cells, Anaerobic glycolysis, 030220 oncology & carcinogenesis, Catenin, Cancer research, Heterografts, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb4af7d2481ec282960df850bd56d93Test
https://doi.org/10.1016/j.canlet.2021.06.023Test

3

The effects of Naja sumatrana venom cytotoxin, sumaCTX on alteration of the secretome in MCF-7 breast cancer cells following membrane permeabilization

المؤلفون: Michelle Khai Khun Yap, Jia Jin Hiu

المصدر: International Journal of Biological Macromolecules. 184:776-786

مصطلحات موضوعية: Proteomics, Programmed cell death, Cell Membrane Permeability, Time Factors, Cell Survival, Necroptosis, Breast Neoplasms, Venom, 02 engineering and technology, medicine.disease_cause, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Tandem Mass Spectrometry, Structural Biology, Lactate dehydrogenase, medicine, Animals, Humans, Cobra Neurotoxin Proteins, Molecular Biology, 030304 developmental biology, Elapid Venoms, 0303 health sciences, Dose-Response Relationship, Drug, Toxin, Naja, General Medicine, Metabolism, 021001 nanoscience & nanotechnology, Molecular biology, Gene Expression Regulation, Neoplastic, chemistry, MCF-7, Apoptosis, MCF-7 Cells, Female, 0210 nano-technology, Chromatography, Liquid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb36fa614ee30c276ee69b80e995532bTest
https://doi.org/10.1016/j.ijbiomac.2021.06.145Test

4

Intramammary antibiotics with complementary acupuncture decreases milk serum N‐acetyl‐beta‐D‐glucosaminidase concentrations in dairy cattle with subclinical mastitis

المؤلفون: Elise Lauren Ryan, Michelle A. Kutzler, Joseph J. Klopfenstein

المصدر: Reproduction in Domestic Animals. 55:1747-1755

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9e9cd2d4497516280311493c79e284Test
https://doi.org/10.1111/rda.13835Test

5

Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia

المؤلفون: Zhao Cheng, Zhihua Wang, Yi-Fang Yi, Wen-Yong Kuang, Lingli Yuan, Hongling Peng, Guangsen Zhang, Yafei Yin, Yajuan Cui, Fan-Jie Gong, Ruijuan Li, Heng Li, Haiying Zhong, Haizhi Yu

المصدر: Cancer Communications, Vol 40, Iss 10, Pp 501-517 (2020)
Cancer Communications

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, CRISPR/Cas9 gene‐editing, oxamate, T-Lymphocytes, Lactate dehydrogenase A, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Jurkat cells, lcsh:RC254-282, LDHA, Animals, Genetically Modified, Proto-Oncogene Proteins c-myc, Jurkat Cells, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, education, Protein kinase B, GSK3B, Zebrafish, PI3K/AKT/mTOR pathway, Oxamic Acid, education.field_of_study, Gene knockdown, Glycogen Synthase Kinase 3 beta, Kinase, Chemistry, Original Articles, Cell cycle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, T‐cell lymphoblastic leukemia, 030104 developmental biology, Oncology, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, transgenic zebrafish model, Original Article, Female, Lactate Dehydrogenase 5, Proto-Oncogene Proteins c-akt, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a7a0d309db1a672a3721ab79b90911Test
https://doaj.org/article/05c2fa1e4b2c4d5f9ac1b8904efb8186Test

6

CB11, a novel purine-based PPARɣ ligand, overcomes radio-resistance by regulating ATM signalling and EMT in human non-small-cell lung cancer cells

المؤلفون: Da-Won Hong, Sung Hee Hong, Tae Woo Kim, Joung Whan Park

المصدر: British Journal of Cancer

مصطلحات موضوعية: Cancer Research, Cell cycle checkpoint, Lung Neoplasms, Cancer therapy, Apoptosis, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Ligands, Radiation Tolerance, chemistry.chemical_compound, Mice, 0302 clinical medicine, Onium Compounds, Carcinoma, Non-Small-Cell Lung, Adipocytes, Anilides, RNA, Small Interfering, Receptor, Cytotoxicity, Luciferases, Membrane Potential, Mitochondrial, Mice, Inbred BALB C, NADPH oxidase, biology, Cell Death, Chemistry, Caspase 3, Imidazoles, Cell Differentiation, 3T3 Cells, Caspase 9, Tumor Burden, Oncology, 030220 oncology & carcinogenesis, Female, Lung cancer, Signal Transduction, Programmed cell death, Epithelial-Mesenchymal Transition, Mice, Nude, Article, 03 medical and health sciences, Lactate dehydrogenase, Cell Line, Tumor, medicine, Animals, Humans, L-Lactate Dehydrogenase, Cell Cycle Checkpoints, medicine.disease, PPAR gamma, Purines, biology.protein, Cancer research, Thiazolidinediones, Tumor Suppressor Protein p53, Reactive Oxygen Species, Azo Compounds, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3d84cfb28effda0709cc85c379ee0aTest
http://europepmc.org/articles/PMC7723055Test

7

Activities of Succinate Dehydrogenase and Lactate Dehydrogenase in Blood Lymphocytes in Yakut Ground Squirrels Spermophilus undulatus During Hibernation and in the Active State

المؤلفون: N. V. Khunderyakova, N. M. Zakharova

المصدر: Bulletin of Experimental Biology and Medicine. 169:445-449

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cfc6c858d3551acfaab9f6ce6823b4Test
https://doi.org/10.1007/s10517-020-04906-6Test

8

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

المؤلفون: Emad S. Alnemri, Teresa Fernandes-Alnemri, Jian Xie, Victor L. J. Tybulewicz, Aura Enache, Robert Köchl, Lindsey Mayes-Hopfinger, Chou Long Huang

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Pyrrolidines, Inflammasomes, Neutrophils, Interleukin-1beta, General Physics and Astronomy, Inflammasome, 0302 clinical medicine, WNK Lysine-Deficient Protein Kinase 1, Conditional gene knockout, Multidisciplinary, integumentary system, Chemistry, Caspase 1, Pyroptosis, Imidazoles, Cell biology, 030220 oncology & carcinogenesis, Female, Intracellular, medicine.drug, Cell death, Science, Protein Serine-Threonine Kinases, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, Proinflammatory cytokine, 03 medical and health sciences, Chlorides, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Kinase activity, Monocytes and macrophages, Innate immune system, L-Lactate Dehydrogenase, Macrophages, General Chemistry, Immunity, Innate, Mice, Inbred C57BL, Tamoxifen, 030104 developmental biology, Potassium

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f780841c38901b3d5be2b16ce4f2bdTest
https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6cTest

9

Neurotrophic Factors Secreted by Induced Pluripotent Stem Cell-Derived Retinal Progenitors Promote Retinal Survival and Preservation in an Adult Porcine Neuroretina Model

المؤلفون: Christina L. Rettinger, Teresa A Burke, Heuy-Ching Hetty Wang, Ramesh R. Kaini

المصدر: Journal of Ocular Pharmacology and Therapeutics. 37:301-312

مصطلحات موضوعية: Adult, 0301 basic medicine, Cell Survival, Swine, Induced Pluripotent Stem Cells, Apoptosis, Enzyme-Linked Immunosorbent Assay, Biology, Regenerative Medicine, Retina, 03 medical and health sciences, chemistry.chemical_compound, Paracrine signalling, 0302 clinical medicine, Neurotrophic factors, medicine, Animals, Humans, Pharmacology (medical), Nerve Growth Factors, Progenitor cell, Induced pluripotent stem cell, Pharmacology, L-Lactate Dehydrogenase, Stem Cells, Retinal, Immunohistochemistry, Cell biology, Ophthalmology, Neuroprotective Agents, 030104 developmental biology, medicine.anatomical_structure, chemistry, Models, Animal, 030221 ophthalmology & optometry, Female, Hepatocyte growth factor, sense organs, Cell activation, Neuroglia, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619f0c234bf5105fcf94f24854e6eac1Test
https://doi.org/10.1089/jop.2020.0088Test

10

In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives

المؤلفون: Seyed-Mahdi Mohamadi-Zarch, Hamzeh Rahimi, Ali Eslamifar, Azar Tahghighi, Mahya Marashiyan, Naseh Maleki-Ravasan

المصدر: Malaria Journal, Vol 19, Iss 1, Pp 1-12 (2020)
Malaria Journal

مصطلحات موضوعية: 0301 basic medicine, lcsh:Arctic medicine. Tropical medicine, Plasmodium berghei, lcsh:RC955-962, 030106 microbiology, Plasmodium falciparum, Protozoan Proteins, Quinoline, Histopathology, Pharmacology, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Mice, 0302 clinical medicine, In vivo, Lactate dehydrogenase, Animals, Computer Simulation, Tissue Distribution, lcsh:RC109-216, 030212 general & internal medicine, Mice, Inbred BALB C, biology, L-Lactate Dehydrogenase, Research, Quinazoline, biology.organism_classification, Acute toxicity, In vitro, Molecular Docking Simulation, Infectious Diseases, Hydrazines, chemistry, Pharmacodynamics, Docking (molecular), Toxicity, Anti-plasmodial activity, Parasitology, Female, Docking study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d3218d98436050f60ee69936a584c7Test
http://link.springer.com/article/10.1186/s12936-020-03269-7Test

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