المؤلفون: Jie Li, Xiaoyun Zhu, Jie Zou, Hao Zhang, Dejuan Xiang, Ling-Yi Kong, Zhigui Su, Yanqiu Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1578-1591 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Hepatocellular carcinoma, NASH, non-alcoholic steatohepatitis, Proliferation, Fructose 1,6-bisphosphatase, RM1-950, Carbohydrate metabolism, LIX1L, Limb and CNS expressed 1 like, Metastasis, 03 medical and health sciences, 0302 clinical medicine, FBP1, CCl4, carbon tetrachloride, miRNA, microRNA, medicine, shRNA, short-hairpin RNA, General Pharmacology, Toxicology and Pharmaceutics, 030304 developmental biology, Glucose metabolism, 0303 health sciences, Gene knockdown, ECAR, extracellular acidification rate, biology, business.industry, Gluconeogenesis, Cell migration, medicine.disease, Seq, sequencing, LIX1L, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Original Article, miR-21-3p, Therapeutics. Pharmacology, HCC, hepatocellular carcinoma, Liver cancer, business, EMT, epithelial–mesenchymal transition, FBP1, fructose-1,6-bisphosphatase 1, DEN, diethylnitrosamine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c970bf879a240521753514a3be8c82cTest
https://doi.org/10.1016/j.apsb.2021.02.005Test

المؤلفون: Raluca Pais, Rachel Ostroff, Stephen Harrison, Lars Friis Mikkelsen, Elisabeth Erhardtsen, Sudha Shankar, Kimmo Porthan, Jérôme Boursier, Antonia Sinisi, Michael Kalutkiewicz, Sven Francque, Miljen Martic, Vanessa Pellegrinelli, Phil N. Newsome, Guido Hanauer, Hannele Yki-Järvinen, Rebecca Darlay, Joel Myers, Carla Yunis, Salvatore Petta, Mette Skalshøi Kjær, Pablo Ortiz, Ann K. Daly, James H. Clark, Dina Tiniakos, Yasaman Vali, Hadi Zafarmand, Matej Orešič, Maurizio Parola, Estelle Sandt, Lori L. Jennings, Matt Kelly, Tuulia Hyötyläinen, Detlef Schuppan, Céline Fournier, Chiara Rosso, Diane E. Shevell, Maria Manuela Tonini, Paul Hockings, Aidan McGlinchey, Salma Akhtar, Mette Juul Fisker, Morten A. Karsdal, Diane Whalley, Melissa R. Miller, Aldo Trylesinski, Mattias Ekstedt, Stefan Neubauer, Jeremy M. Palmer, Partho Sen, Michael Pavlides, Per Qvist, Isabel Fernández, Luca Miele, Fabio Marra, Stergios Kechagias, Richard Torstenson, Katherine Johnson, Jean-François Dufour, Elisabetta Bugianesi, M. Julia Brosnan, George V. Papatheodoridis, Kay M. Pepin, Daniel Guldager Kring Rasmussen, Henrik Landgren, Rachel Queen, Simon Cockell, Michael Allison, Patrick M.M. Bossuyt, Rocío Gallego-Durán, Christian Rosenquist, Leigh Alexander, Elizabeth Shumbayawonda, Michele Vacca, Antonio Vidal-Puig, David Wenn, Rémy Hanf, Oscar Millet, Michalina Zatorska, R. Myers, José M. Mato, Jenny Lee, Theresa Tuthill, James Twiss, Ramy Younes, Peter Leary, Lynda Doward, Kristy Wonders, Guruprasad P. Aithal, Sarah Charlton, Vlad Ratziu, Cecília M. P. Rodrigues, Christian Trautwein, Helena Cortez-Pinto, Gideon Ho, Matt J. Barter, Judith Ertle, Jörn M. Schattenberg, Maria-Magdalena Balp, Yang-Lin Liu, Clifford A. Brass, Olivier Govaere, Amalia Gastaldelli, Sergio Rodriguez Cuenca, Pierre Chaumat, Fiona Oakley, Luca Valenti, Simon J. Cockell, Saskia W.C. van Mil, Ferenc E. Mózes, Andreas Geier, Timothy Hardy, Pierre Bedossa, Andrea Dennis, Richard L. Ehman, Charlotte Erpicum, Karine Clément, Jeremy F. L. Cobbold, Christopher P. Day, Rajarshi Banerjee, Manuel Romero-Gómez, Quentin M. Anstee, Adriaan G. Holleboom, Heather J. Cordell, Kevin L. Duffin, Diana Julie Leeming

المساهمون: Epidemiology and Data Science, APH - Methodology, APH - Personalized Medicine, Vascular Medicine, ACS - Diabetes & metabolism, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, ARD - Amsterdam Reproduction and Development, Graduate School, Investigators, LITMUS Consortium, Johnson K., Leary P.J., Govaere O., Barter M.J., Charlton S.H., Cockell S.J., Tiniakos D., Zatorska M., Bedossa P., Brosnan M.J., Cobbold J.F., Ekstedt M., Aithal G.P., Clement K., Schattenberg J.M., Boursier J., Ratziu V., Bugianesi E., Anstee Q.M., Daly A.K., Clark J., Cordell H.J., Darlay R., Day C.P., Hardy T., Liu Y.-L., Oakley F., Palmer J., Queen R., Wonders K., Bossuyt P.M., Holleboom A.G., Zafarmand H., Vali Y., Lee J., Pais R., Schuppan D., Allison M., Cuenca S.R., Pellegrinelli V., Vacca M., Vidal-Puig A., Hyotylainen T., McGlinchey A., Oresic M., Sen P., Mato J., Millet O., Dufour J.-F., Harrison S., Neubauer S., Pavlides M., Mozes F., Akhtar S., Banerjee R., Kelly M., Shumbayawonda E., Dennis A., Erpicum C., Romero-Gomez M., Gallego-Duran R., Fernandez I., Karsdal M., Leeming D., Fisker M.J., Erhardtsen E., Rasmussen D., Qvist P., Sinisi A., Sandt E., Tonini M.M., Parola M., Rosso C., Marra F., Gastaldelli A., Francque S., Kechagias S., Yki-Jarvinen H., Porthan K., van Mil S., Papatheodoridis G., Cortez-Pinto H., Valenti L., Petta S., Miele L., Geier A., Trautwein C., Hockings P., Newsome P., Wenn D., Pereira Rodrigues C.M., Hanf R., Chaumat P., Rosenquist C., Trylesinski A., Ortiz P., Duffin K., Yunis C., Miller M., Tuthill T., Ertle J., Younes R., Alexander L., Ostroff R., Kjaer M.S., Mikkelsen L.F., Brass C., Jennings L., Balp M.-M., Martic M., Hanauer G., Shankar S., Torstenson R., Fournier C., Ehman R., Kalutkiewicz M., Pepin K., Myers J., Shevell D., Ho G., Landgren H., Myers R., Doward L., Whalley D., Twiss J., Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Alexander, Leigh, Ostroff, Rachel, Kjær, Mette Skalshøi, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Fournier, Céline, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Myers, Rob, Doward, Lynda, Whalley, Diane, Twiss, James, Clark, James, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Wonders, Kristy, Bossuyt, Patrick M., Holleboom, Adriaan G., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, Vidal-Puig, Antonio, Hyötyläinen, Tuulia, McGlinchey, Aidan, Orešič, Matej, Sen, Partho, Mato, Jose, Millet, Óscar, Dufour, Jean-Francois, Harrison, Stephen, Neubauer, Stefan, Pavlides, Michael, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Gallego-Durán, Rocío, Fernández, Isabel, Karsdal, Morten, Leeming, Diana, Fisker, Mette Juul, Erhardtsen, Elisabeth, Rasmussen, Daniel, Qvist, Per, Sinisi, Antonia, Sandt, Estelle, Tonini, Maria Manuela, Parola, Maurizio, Rosso, Chiara, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Miele, Luca, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Wenn, David, Pereira Rodrigues, Cecília Maria, Hanf, Rémy, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Ortiz, Pablo, Duffin, Kevin, Yunis, Carla

المصدر: JHEP Reports, 4(2):100409. Elsevier
JHEP Reports
JHEP Reports, Vol 4, Iss 2, Pp 100409-(2022)
JHEP reports 4(2), 100409 (2022). doi:10.1016/j.jhepr.2021.100409

مصطلحات موضوعية: SCORING SYSTEM, CPM, counts per million, AUROC, area under the receiver operating characteristic, RC799-869, AST, aspartate aminotransferase, MicroRNA, Non-alcoholic fatty liver disease, Biomarker, Sequencing, TGF-β, transforming growth factor-beta, Gastroenterology, STEATOHEPATITIS, Liver disease, 0302 clinical medicine, Fibrosis, miRNA, microRNA, logFC, log2 fold change, FIBROSIS, Immunology and Allergy, 0303 health sciences, education.field_of_study, NAS, NAFLD activity score, medicine.diagnostic_test, Fatty liver, GTEx, Genotype-Tissue Expression, Diseases of the digestive system. Gastroenterology, 3. Good health, Real-time polymerase chain reaction, Biomarker, MicroRNA, Non-alcoholic fatty liver disease, Sequencing, Liver biopsy, ACID, Biomarker (medicine), 030211 gastroenterology & hepatology, Life Sciences & Biomedicine, Research Article, EXPRESSION, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, NASH, non-alcoholic steatohepatitis, Population, Gastroenterology and Hepatology, SAF, steatosis–activity–fibrosis, VALIDATION, ER, endoplasmic reticulum, 03 medical and health sciences, cDNA, complementary DNA, Internal medicine, ALT, alanine aminotransferase, Gastroenterologi, Internal Medicine, medicine, NAFL, non-alcoholic fatty liver, ALGORITHM, FIB-4, fibrosis-4, education, 030304 developmental biology, PCA, principal component analysis, Science & Technology, Gastroenterology & Hepatology, Hepatology, business.industry, FC, fold change, medicine.disease, digestive system diseases, FLIP, fatty liver inhibition of progression, Ct, cycle threshold, Steatosis, qPCR, quantitative PCR, business

وصف الملف: application/pdf; Electronic-eCollection

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c39a3a5921e0d464a7b2b93c40ef52cTest
https://pure.amc.nl/en/publications/increased-serum-mir193a5p-during-nonalcoholic-fatty-liver-disease-progressionTest(bd6dd66c-d686-4b4d-be46-956a848f1f3b).html

المؤلفون: N. Thao N. Galvan, Mercedes Barzi, John A. Goss, William R. Lagor, David D. Moore, Adam Dean, Neil J. McKenna, Pavel Sumazin, Barry Zorman, Diane Yang, Beatrice Bissig-Choisat, Karl-Dimiter Bissig, Xavier Legras, David E. Cohen, Robert Brian York, Malgorzata Borowiak, Michele Alves-Bezerra, Scott A. Ochsner

المصدر: JHEP reports : innovation in hepatology, vol 3, iss 3
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100281-(2021)

مصطلحات موضوعية: phosphatidylinositol, Cirrhosis, Steatosis, ALT, hexosylceramide, Humanised mice, SREBP, sterol regulatory element-binding protein, PI, RC799-869, CMHs, chimeric mouse hepatocytes, 0302 clinical medicine, GGT, gamma-glutamyl transpeptidase, aspartate aminotransferase, HCC, gamma-glutamyl transpeptidase, chemistry.chemical_classification, 0303 health sciences, education.field_of_study, Western-type diet, Gastroenterology, NASH, CHHs, Diseases of the digestive system. Gastroenterology, 3. Good health, confidence transcript, HCT, cholesteryl ester, human albumin, DCER, dihydroceramide, 030211 gastroenterology & hepatology, PC, non-alcoholic steatohepatitis, PE, transgene-free Il2rg-/-/Rag2-/-/Fah, free fatty acid, LPE, lysophosphatidylethanolamine, DCER, NASH, non-alcoholic steatohepatitis, HCER, hexosylceramide, NC, normal chow, TIRF, PE, phosphatidylethanolamine, nitisinone, lysophosphatidylethanolamine, 03 medical and health sciences, dihydroceramide, Human disease modelling, NAFLD, FFA, free fatty acid, LCER, DEG, MUFA, education, phosphatidylcholine, chimeric mouse hepatocytes, FAH, SM, sphingomyelin, ALP, alkaline phosphatase, FA, fatty acid, NTBC, Fatty acid, medicine.disease, differentially expressed gene, lactosylceramide, PNPLA3, patatin-like-phospholipase domain-containing protein 3, Lipid metabolism, chemistry, fatty acid, PUFA, hALB, human albumin, TIRF, transgene-free Il2rg-/-/Rag2-/-/Fah, AST, aspartate aminotransferase, CT, confidence transcript, PC, phosphatidylcholine, monounsaturated fatty acid, DEG, differentially expressed gene, MUFA, monounsaturated fatty acid, Immunology and Allergy, MAG, monoacylglycerol, PUFA, polyunsaturated free FA, CE, cholesteryl ester, CER, diacylglycerol, FAH, fumarylacetoacetate hydrolase, Fatty liver, SM, chimeric human hepatocytes, hepatocellular carcinoma, CBPEGs, cholesterol biosynthesis pathway enzyme genes, CE, MAG, LPC, patatin-like-phospholipase domain-containing protein 3, triacylglycerol, LPE, alkaline phosphatase, sterol regulatory element-binding protein, Polyunsaturated fatty acid, Research Article, CT, NAFLD, non-alcoholic fatty liver disease, FA, HCER, TAG, triacylglycerol, fumarylacetoacetate hydrolase, monoacylglycerol, alanine aminotransferase, Population, cholesterol biosynthesis pathway enzyme genes, Biology, SREBP, PI, phosphatidylinositol, sphingomyelin, lysophosphatidylcholine, WD, ALT, alanine aminotransferase, high confidence transcriptional target, Internal Medicine, medicine, CBPEGs, ceramide, hALB, LCER, lactosylceramide, normal chow, AST, polyunsaturated free FA, WD, Western-type diet, PNPLA3, 030304 developmental biology, Hepatitis, LPC, lysophosphatidylcholine, Hepatology, DAG, non-alcoholic fatty liver disease, NTBC, nitisinone, CMHs, GGT, HCT, high confidence transcriptional target, phosphatidylethanolamine, TAG, Cancer research, CHHs, chimeric human hepatocytes, ALP, Liver function, NC, CER, ceramide, HCC, hepatocellular carcinoma, FFA, DAG, diacylglycerol, Non-alcoholic fatty liver disease

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b0393a5555874a5526c491b8421dfdTest
https://escholarship.org/uc/item/2hg8h2x9Test

المؤلفون: Lucia Parlati, Catherine Postic, Marion Régnier, Hervé Guillou

المساهمون: LESUR, Hélène, Impact du métabolisme des acides gras des tissus adipeux et du foie sur l'insulinorésistance - - HepAdialogue2017 - ANR-17-CE14-0015 - AAPG2017 - VALID, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Catholique de Louvain = Catholic University of Louvain (UCL), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Lucia Parlati and Catherine Postic received funding from the French association for the study of the liver (AFEF). Catherine Postic and Herve Guillou received funding from the Agence Nationale de la Recherche (ANR-17-CE14-0015Hepadialogue)., ANR-17-CE14-0015,HepAdialogue,Impact du métabolisme des acides gras des tissus adipeux et du foie sur l'insulinorésistance(2017), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

المصدر: JHEP Reports
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩

مصطلحات موضوعية: HFD, high-fat diet, SREBP-1c, [SDV]Life Sciences [q-bio], Disease, Review, ACC, acetyl-CoA carboxylase, ASK1, apoptosis signal-regulating kinase 1, Chronic liver disease, Bioinformatics, ChREBP, carbohydrate responsive element–binding protein, PPARα, NEFA, TNF-α, tumour necrosis factor-α, 0302 clinical medicine, Fibrosis, Immunology and Allergy, Medicine, IL-, interleukin, VLDL, very low-density lipoprotein, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, NEFA, non-esterified fatty acid, Fatty liver, Gastroenterology, NASH, lipotoxicity, FAS, fatty acid synthase, animal models, 3. Good health, [SDV] Life Sciences [q-bio], PY, persons/years, Lipotoxicity, FXR, Saturated fatty acid, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, LXR, CAP, controlled attenuation parameter, HSL, hormone-sensitive lipase, HSC, hepatic stellate cells, GGT, gamma glutamyltransferase, NAFLD, non-alcoholic fatty liver disease, ChREBP, NASH, non-alcoholic steatohepatitis, SFA, saturated fatty acid, TCA, tricarboxylic acid, Phf2, histone demethylase plant homeodomain finger 2, digestive system, 03 medical and health sciences, glucotoxicity, FXR, farnesoid X receptor, NAFLD, FFA, free fatty acid, Internal Medicine, RCT, randomised controlled trial, Liver X receptor, PPARa, 030304 developmental biology, FGF21, fibroblast growth factor-21, MCD, methionine- and choline-deficient, HVPG, hepatic venous pressure gradient, Hepatology, business.industry, PUFAs, polyunsaturated fatty acids, nutritional and metabolic diseases, TLR4, Toll-like receptor 4, SCD1, stearoyl-CoA desaturase-1, medicine.disease, digestive system diseases, PPARα, peroxisome proliferator-activated receptor-α, SREBP-1c, sterol regulatory element–binding protein-1c, Steatosis, LXR, liver X receptor, business, HCC, hepatocellular carcinoma, MUFA, monounsaturated fatty acids, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba31673956635c337dc60791ff712432Test
https://pubmed.ncbi.nlm.nih.gov/34667947Test

المؤلفون: Alice P. Sowton, Andrew J. Murray, Simon James Tunster, Erica D. Watson, Ben D. McNally, Nisha Padmanabhan, Julian L. Griffin, Antonio Murgia, Aisha Yusuf

المساهمون: Medical Research Council, Medical Research Council (MRC), Sowton, Alice [0000-0002-3718-7783], Tunster, Simon [0000-0002-2242-9452], Murray, Andrew [0000-0002-0929-9315], Watson, Erica [0000-0003-4496-2271], Apollo - University of Cambridge Repository, Watson, Erica D [0000-0003-4496-2271]

المصدر: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 23, Iss, Pp-(2020)

مصطلحات موضوعية: CE, cholesteryl-ester, LC-MS, liquid chromatography-mass spectrometry, 5-methyl-THF, 5-methyltetrahydofolate, OXPHOS, oxidative phosphorylation, G6pc, glucose 6-phophastase gene, PG, phosphatidylglycerol, 0601 Biochemistry and Cell Biology, Gyg, glycogenin gene, PIP, phosphatidylinositol phosphate(s), Cebpa, CCAAT/enhancer binding protein (C/EBP), alpha gene, chemistry.chemical_compound, Isca1, iron‑sulfur cluster assembly 1 gene, PC, phosphatidylcholine, 0302 clinical medicine, Endocrinology, Nonalcoholic fatty liver disease, One‑carbon metabolism, PA, phosphatidic acid, lcsh:QH301-705.5, 0303 health sciences, lcsh:R5-920, biology, Glycogen, FCCP, p-trifluoromethoxyphenyl hydrazine, 030305 genetics & heredity, SAM, S-adenosylmethionine, Mthfr, methylenetetrahydrofolate reductase gene, Mtr, methionine synthase gene (also MS), PS, phosphatidylserine, 3. Good health, PL, phospholipid, Gsk3, glycogen synthase kinase gene, RIPA, Radioimmunoprecipitation assay, Agl, amylo-alpha-1,6-glucosidase,4-alpha-glucanotransferase gene, Ndufs, NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene, Liver metabolism, Bhmt, betaine-homocysteine S-methyltransferase gene, Hepatic fuel storage, lcsh:Medicine (General), Gbe1, glycogen branching enzyme 1 gene, Research Paper, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, TAG, triacylglycerol, NASH, non-alcoholic steatohepatitis, Cer, ceramide, PE, phosphatidylethanolamine, PI, phosphatidylinositol, 03 medical and health sciences, Internal medicine, FFA, free fatty acid, Genetics, medicine, JO2, oxygen flux, Glycogen synthase, GSK3A, Molecular Biology, Myc, myelocytomatosis oncogene, 0604 Genetics, Methionine, LPC, lysophosphatidylcholine, SM, sphingomyelin, Ddit3, DNA damage inducible transcript 3 gene, SAH, S-adenosylhomocysteine, Lipid metabolism, (Methionine synthase) reductase, Gys2, glycogen synthase 2 gene, Ugp2, UDP-glucose pyrophophorylase 2 gene, medicine.disease, MTRR, HOAD, 3-hydoxyacyl-CoA dehydrogenase, BCA, bicinchoninic acid, Mtrr, methionine synthase reductase gene (also MSR), chemistry, lcsh:Biology (General), gt, gene-trap, Lipidomics, biology.protein, Mitochondrial function, PAS, periodic acid Schiff, DAG, diacylglycerol, 030217 neurology & neurosurgery, ETS, electron transport system

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5de79e1f7ef67cef5ce425b58d812c6Test
http://hdl.handle.net/10044/1/82233Test

المؤلفون: Jérôme Boursier, Emmanuel Tsochatzis

المساهمون: Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)

المصدر: JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100219. ⟨10.1016/j.jhepr.2020.100219⟩
JHEP Reports

مصطلحات موضوعية: Cirrhosis, Cost effectiveness, [SDV]Life Sciences [q-bio], NICE, National Institute of Clinical Excellence, Nice, Review, AST, aspartate aminotransferase, Disease, Patient pathway, ELF, enhanced liver fibrosis, 0302 clinical medicine, Immunology and Allergy, Medicine, NFS, NAFLD fibrosis score, ALD, alcohol-related liver disease, ComputingMilieux_MISCELLANEOUS, computer.programming_language, 0303 health sciences, NAS, NAFLD activity score, Case-finding, Fatty liver, Gastroenterology, Awareness, Primary care, TE, transient elastography, 3. Good health, Screening, FIB-4, 030211 gastroenterology & hepatology, Elastography, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, NASH, non-alcoholic steatohepatitis, Liver fibrosis, QALY, quality-adjusted life year, 03 medical and health sciences, ALT, alanine aminotransferase, Type 2 diabetes mellitus, NIT, non-invasive test, Internal Medicine, GP, general practitioner, FIB-4, fibrosis-4, Intensive care medicine, 030304 developmental biology, Hepatology, business.industry, Type 2 Diabetes Mellitus, T2DM, type 2 diabetes mellitus, medicine.disease, Quality-adjusted life year, Cost-effectiveness, Transient elastography, business, computer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998a5dc5ae8854bb83716af6e6873dc7Test
https://doi.org/10.1016/j.jhepr.2020.100219Test

المؤلفون: Xuemei Wang, Wei Kong, Yuanyuan Pang, Lulu Sun, Huiying Liu, Bo Liu, Min Ye, Qing Wu, George Liu, Changtao Jiang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 4, Pp 702-710 (2019)

مصطلحات موضوعية: eWAT, epididymal white adipose tissue, Metabolic disorders, White adipose tissue, Gut flora, UPLC–MS/MS, ultra performance liquid chromatography–tandem mass spectrometry, 0302 clinical medicine, HFD, high fat diet, AST, aspartate transaminase, GCA, glycocholic acid, VLDL, very low-density lipoprotein, TβMCA, General Pharmacology, Toxicology and Pharmaceutics, LCA, lithocholic acid, CAPE, caffeic acid phenethyl ester, TβMCA, tauro-β-muricholic acid, 0303 health sciences, CA, cholic acid, GCDCA, glycochenodeoxycholic acid, CYP7B1, biology, Bile acid, Chemistry, sWAT, subcutaneous white adipose tissue, FGF15/19, fibroblast growth factor 15/19, TG, triglycerides, CETP, cholesterol ester transfer protein, CYP7A1, cytochrome P450 family 7 subfamily A member 1, FXR, 030220 oncology & carcinogenesis, GTT, glucose tolerance test, BSH, bile acid hydrolase, CYP7B1, cytochrome P450 family 7 subfamily B member 1, medicine.medical_specialty, Original article, NAFLD, non-alcoholic fatty liver disease, PBA/SBA, primary bile acids to secondary bile acids, medicine.drug_class, NASH, non-alcoholic steatohepatitis, TCA, taurocholic acid, Hamster, ALT, alanine amino-transferase, CYP8B1, cytochrome P450 family 8 subfamily B member 1, T2D, type 2 diabetes, Gut microbiota, AUC, area under curve, digestive system, CYP27A1, cytochrome P450 family 27 subfamily A member 1, UDCA, ursodeoxycholic acid, CDCA, chenodeoxycholic acid, 03 medical and health sciences, Insulin resistance, FXR, farnesoid X receptor, Internal medicine, medicine, ApoB, apolipoprotein B, 030304 developmental biology, ITT, insulin tolerance test, BAs, bile acids, lcsh:RM1-950, medicine.disease, biology.organism_classification, TC, total cholesterol, lcsh:Therapeutics. Pharmacology, Endocrinology, DCA, deoxycholic acid, H&E, hematoxylin and eosin, Farnesoid X receptor, Steatosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc312ddccc0b191b5f0414f6cd3240aTest
https://pubmed.ncbi.nlm.nih.gov/31384531Test

المؤلفون: Alexandra K. Leamy, Jamey D. Young, Robert A. Egnatchik, Masakazu Shiota, David A. Jacobson

المصدر: Molecular Metabolism

مصطلحات موضوعية: NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, SERCA, NASH, non-alcoholic steatohepatitis, SFA, saturated fatty acid, chemistry.chemical_element, Biology, Calcium, Mitochondrion, medicine.disease_cause, PA, palmitate, Calcium in biology, PI, propidium iodide, 03 medical and health sciences, chemistry.chemical_compound, H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate, ROS, reactive oxygen species, 0302 clinical medicine, BAPTA, Fatty liver, Internal medicine, CAC, citric acid cycle, FFA, free fatty acid, MUFA, monounsaturated fatty acid, medicine, Molecular Biology, MFA, metabolic flux analysis, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, APE, atom percent enrichment, Metabolic flux analysis, Cell Biology, SERCA, sarcoplasmic-endoplasmic reticulum calcium ATPase, 3. Good health, Endocrinology, chemistry, Lipotoxicity, Oxidative stress, OA, oleate, 030220 oncology & carcinogenesis, Original Article, BSA, bovine serum albumin, GC–MS, gas chromatography–mass spectrometry, ER stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8abb056af369ca34e6c97f53de9251Test

المؤلفون: Montserrat Marí, José C. Fernández-Checa, Anna Colell, Albert Morales, Carmen García-Ruiz

المصدر: Redox Biology, Vol 3, Iss C, Pp 100-108 (2014)
Redox Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Alcoholic liver disease, OXPHOS, oxidative phosphorylation, Clinical Biochemistry, Mitochondria, Liver, Mitochondrial GSH, Mitochondrion, medicine.disease_cause, Biochemistry, AH, alcoholic hepatitis, 0302 clinical medicine, GSH, glutathione, FFA, free fatty acids, Acid sphingomyelinase, TNF, tumor necrosis factor, lcsh:QH301-705.5, 0303 health sciences, lcsh:R5-920, CYP2E1, cytochrome P450 2E1, ASMase, acid sphingomyelinase, TG, triglycerides, Endoplasmic Reticulum Stress, Glutathione, 3. Good health, Cell biology, MRC, mitochondrial respiratory chain, Mitochondrial cholesterol, Cholesterol, Sphingomyelin Phosphodiesterase, Mitochondrial respiratory chain, ASH, alcoholic steatohepatitis, Lipotoxicity, 030211 gastroenterology & hepatology, ER stress, lcsh:Medicine (General), Research Paper, medicine.medical_specialty, ALD, alcoholic liver disease, mGSH, mitochondrial GSH, SH, steatohepatitis, NASH, non-alcoholic steatohepatitis, Oxidative phosphorylation, Biology, ER, endoplasmic reticulum, 03 medical and health sciences, ROS, reactive oxygen species, SOD, superoxide dismutase, Internal medicine, medicine, Animals, Humans, Liver Diseases, Alcoholic, 030304 developmental biology, Endoplasmic reticulum, Organic Chemistry, medicine.disease, Endocrinology, lcsh:Biology (General), Unfolded protein response, NAFLD, nonalcoholic fatty liver disease, Reactive Oxygen Species, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef38e86f50b5350b0acad0cb4e609e11Test
http://www.sciencedirect.com/science/article/pii/S2213231714001049Test

المؤلفون: Maelle Morgan, Barbara Sigalla, J Soeda, Chad McKee, Tania Roskams, Esra Asilmaz, Jude A. Oben, Nicoletta Sinelli

المصدر: Biochemical and Biophysical Research Communications

مصطلحات موضوعية: Male, Cirrhosis, Apoptosis, HPC, hepatic progenitor cell, Biochemistry, Choline, Mice, chemistry.chemical_compound, 0302 clinical medicine, Ethionine, Liver injury, 0303 health sciences, Stem Cells, Alanine Transaminase, Fas receptor, Propranolol, 3. Good health, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Hepatocyte, PRZ, prazosin, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, Fas Ligand Protein, NASH, non-alcoholic steatohepatitis, Adrenergic beta-Antagonists, Biophysics, Biology, Article, 03 medical and health sciences, Internal medicine, Receptors, Adrenergic, beta, medicine, Animals, Molecular Biology, 030304 developmental biology, L-Lactate Dehydrogenase, Tumor Necrosis Factor-alpha, PRL, propranolol, OC, oval cell, Antagonist, Cell Biology, medicine.disease, Culture Media, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, Endocrinology, chemistry, Sympathetic nervous system, Hepatocytes, Hepatic stellate cell, Steatohepatitis, Non-alcoholic fatty liver disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f003a82453155f5ae4f332cad7b55123Test
https://doi.org/10.1016/j.bbrc.2013.07.005Test