المؤلفون: Raluca Pais, Rachel Ostroff, Stephen Harrison, Lars Friis Mikkelsen, Elisabeth Erhardtsen, Sudha Shankar, Kimmo Porthan, Jérôme Boursier, Antonia Sinisi, Michael Kalutkiewicz, Sven Francque, Miljen Martic, Vanessa Pellegrinelli, Phil N. Newsome, Guido Hanauer, Hannele Yki-Järvinen, Rebecca Darlay, Joel Myers, Carla Yunis, Salvatore Petta, Mette Skalshøi Kjær, Pablo Ortiz, Ann K. Daly, James H. Clark, Dina Tiniakos, Yasaman Vali, Hadi Zafarmand, Matej Orešič, Maurizio Parola, Estelle Sandt, Lori L. Jennings, Matt Kelly, Tuulia Hyötyläinen, Detlef Schuppan, Céline Fournier, Chiara Rosso, Diane E. Shevell, Maria Manuela Tonini, Paul Hockings, Aidan McGlinchey, Salma Akhtar, Mette Juul Fisker, Morten A. Karsdal, Diane Whalley, Melissa R. Miller, Aldo Trylesinski, Mattias Ekstedt, Stefan Neubauer, Jeremy M. Palmer, Partho Sen, Michael Pavlides, Per Qvist, Isabel Fernández, Luca Miele, Fabio Marra, Stergios Kechagias, Richard Torstenson, Katherine Johnson, Jean-François Dufour, Elisabetta Bugianesi, M. Julia Brosnan, George V. Papatheodoridis, Kay M. Pepin, Daniel Guldager Kring Rasmussen, Henrik Landgren, Rachel Queen, Simon Cockell, Michael Allison, Patrick M.M. Bossuyt, Rocío Gallego-Durán, Christian Rosenquist, Leigh Alexander, Elizabeth Shumbayawonda, Michele Vacca, Antonio Vidal-Puig, David Wenn, Rémy Hanf, Oscar Millet, Michalina Zatorska, R. Myers, José M. Mato, Jenny Lee, Theresa Tuthill, James Twiss, Ramy Younes, Peter Leary, Lynda Doward, Kristy Wonders, Guruprasad P. Aithal, Sarah Charlton, Vlad Ratziu, Cecília M. P. Rodrigues, Christian Trautwein, Helena Cortez-Pinto, Gideon Ho, Matt J. Barter, Judith Ertle, Jörn M. Schattenberg, Maria-Magdalena Balp, Yang-Lin Liu, Clifford A. Brass, Olivier Govaere, Amalia Gastaldelli, Sergio Rodriguez Cuenca, Pierre Chaumat, Fiona Oakley, Luca Valenti, Simon J. Cockell, Saskia W.C. van Mil, Ferenc E. Mózes, Andreas Geier, Timothy Hardy, Pierre Bedossa, Andrea Dennis, Richard L. Ehman, Charlotte Erpicum, Karine Clément, Jeremy F. L. Cobbold, Christopher P. Day, Rajarshi Banerjee, Manuel Romero-Gómez, Quentin M. Anstee, Adriaan G. Holleboom, Heather J. Cordell, Kevin L. Duffin, Diana Julie Leeming

المساهمون: Epidemiology and Data Science, APH - Methodology, APH - Personalized Medicine, Vascular Medicine, ACS - Diabetes & metabolism, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, ARD - Amsterdam Reproduction and Development, Graduate School, Investigators, LITMUS Consortium, Johnson K., Leary P.J., Govaere O., Barter M.J., Charlton S.H., Cockell S.J., Tiniakos D., Zatorska M., Bedossa P., Brosnan M.J., Cobbold J.F., Ekstedt M., Aithal G.P., Clement K., Schattenberg J.M., Boursier J., Ratziu V., Bugianesi E., Anstee Q.M., Daly A.K., Clark J., Cordell H.J., Darlay R., Day C.P., Hardy T., Liu Y.-L., Oakley F., Palmer J., Queen R., Wonders K., Bossuyt P.M., Holleboom A.G., Zafarmand H., Vali Y., Lee J., Pais R., Schuppan D., Allison M., Cuenca S.R., Pellegrinelli V., Vacca M., Vidal-Puig A., Hyotylainen T., McGlinchey A., Oresic M., Sen P., Mato J., Millet O., Dufour J.-F., Harrison S., Neubauer S., Pavlides M., Mozes F., Akhtar S., Banerjee R., Kelly M., Shumbayawonda E., Dennis A., Erpicum C., Romero-Gomez M., Gallego-Duran R., Fernandez I., Karsdal M., Leeming D., Fisker M.J., Erhardtsen E., Rasmussen D., Qvist P., Sinisi A., Sandt E., Tonini M.M., Parola M., Rosso C., Marra F., Gastaldelli A., Francque S., Kechagias S., Yki-Jarvinen H., Porthan K., van Mil S., Papatheodoridis G., Cortez-Pinto H., Valenti L., Petta S., Miele L., Geier A., Trautwein C., Hockings P., Newsome P., Wenn D., Pereira Rodrigues C.M., Hanf R., Chaumat P., Rosenquist C., Trylesinski A., Ortiz P., Duffin K., Yunis C., Miller M., Tuthill T., Ertle J., Younes R., Alexander L., Ostroff R., Kjaer M.S., Mikkelsen L.F., Brass C., Jennings L., Balp M.-M., Martic M., Hanauer G., Shankar S., Torstenson R., Fournier C., Ehman R., Kalutkiewicz M., Pepin K., Myers J., Shevell D., Ho G., Landgren H., Myers R., Doward L., Whalley D., Twiss J., Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Alexander, Leigh, Ostroff, Rachel, Kjær, Mette Skalshøi, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Fournier, Céline, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Myers, Rob, Doward, Lynda, Whalley, Diane, Twiss, James, Clark, James, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Wonders, Kristy, Bossuyt, Patrick M., Holleboom, Adriaan G., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, Vidal-Puig, Antonio, Hyötyläinen, Tuulia, McGlinchey, Aidan, Orešič, Matej, Sen, Partho, Mato, Jose, Millet, Óscar, Dufour, Jean-Francois, Harrison, Stephen, Neubauer, Stefan, Pavlides, Michael, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Gallego-Durán, Rocío, Fernández, Isabel, Karsdal, Morten, Leeming, Diana, Fisker, Mette Juul, Erhardtsen, Elisabeth, Rasmussen, Daniel, Qvist, Per, Sinisi, Antonia, Sandt, Estelle, Tonini, Maria Manuela, Parola, Maurizio, Rosso, Chiara, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Miele, Luca, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Wenn, David, Pereira Rodrigues, Cecília Maria, Hanf, Rémy, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Ortiz, Pablo, Duffin, Kevin, Yunis, Carla

المصدر: JHEP Reports, 4(2):100409. Elsevier
JHEP Reports
JHEP Reports, Vol 4, Iss 2, Pp 100409-(2022)
JHEP reports 4(2), 100409 (2022). doi:10.1016/j.jhepr.2021.100409

مصطلحات موضوعية: SCORING SYSTEM, CPM, counts per million, AUROC, area under the receiver operating characteristic, RC799-869, AST, aspartate aminotransferase, MicroRNA, Non-alcoholic fatty liver disease, Biomarker, Sequencing, TGF-β, transforming growth factor-beta, Gastroenterology, STEATOHEPATITIS, Liver disease, 0302 clinical medicine, Fibrosis, miRNA, microRNA, logFC, log2 fold change, FIBROSIS, Immunology and Allergy, 0303 health sciences, education.field_of_study, NAS, NAFLD activity score, medicine.diagnostic_test, Fatty liver, GTEx, Genotype-Tissue Expression, Diseases of the digestive system. Gastroenterology, 3. Good health, Real-time polymerase chain reaction, Biomarker, MicroRNA, Non-alcoholic fatty liver disease, Sequencing, Liver biopsy, ACID, Biomarker (medicine), 030211 gastroenterology & hepatology, Life Sciences & Biomedicine, Research Article, EXPRESSION, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, NASH, non-alcoholic steatohepatitis, Population, Gastroenterology and Hepatology, SAF, steatosis–activity–fibrosis, VALIDATION, ER, endoplasmic reticulum, 03 medical and health sciences, cDNA, complementary DNA, Internal medicine, ALT, alanine aminotransferase, Gastroenterologi, Internal Medicine, medicine, NAFL, non-alcoholic fatty liver, ALGORITHM, FIB-4, fibrosis-4, education, 030304 developmental biology, PCA, principal component analysis, Science & Technology, Gastroenterology & Hepatology, Hepatology, business.industry, FC, fold change, medicine.disease, digestive system diseases, FLIP, fatty liver inhibition of progression, Ct, cycle threshold, Steatosis, qPCR, quantitative PCR, business

وصف الملف: application/pdf; Electronic-eCollection

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c39a3a5921e0d464a7b2b93c40ef52cTest
https://pure.amc.nl/en/publications/increased-serum-mir193a5p-during-nonalcoholic-fatty-liver-disease-progressionTest(bd6dd66c-d686-4b4d-be46-956a848f1f3b).html

المؤلفون: N. Thao N. Galvan, Mercedes Barzi, John A. Goss, William R. Lagor, David D. Moore, Adam Dean, Neil J. McKenna, Pavel Sumazin, Barry Zorman, Diane Yang, Beatrice Bissig-Choisat, Karl-Dimiter Bissig, Xavier Legras, David E. Cohen, Robert Brian York, Malgorzata Borowiak, Michele Alves-Bezerra, Scott A. Ochsner

المصدر: JHEP reports : innovation in hepatology, vol 3, iss 3
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100281-(2021)

مصطلحات موضوعية: phosphatidylinositol, Cirrhosis, Steatosis, ALT, hexosylceramide, Humanised mice, SREBP, sterol regulatory element-binding protein, PI, RC799-869, CMHs, chimeric mouse hepatocytes, 0302 clinical medicine, GGT, gamma-glutamyl transpeptidase, aspartate aminotransferase, HCC, gamma-glutamyl transpeptidase, chemistry.chemical_classification, 0303 health sciences, education.field_of_study, Western-type diet, Gastroenterology, NASH, CHHs, Diseases of the digestive system. Gastroenterology, 3. Good health, confidence transcript, HCT, cholesteryl ester, human albumin, DCER, dihydroceramide, 030211 gastroenterology & hepatology, PC, non-alcoholic steatohepatitis, PE, transgene-free Il2rg-/-/Rag2-/-/Fah, free fatty acid, LPE, lysophosphatidylethanolamine, DCER, NASH, non-alcoholic steatohepatitis, HCER, hexosylceramide, NC, normal chow, TIRF, PE, phosphatidylethanolamine, nitisinone, lysophosphatidylethanolamine, 03 medical and health sciences, dihydroceramide, Human disease modelling, NAFLD, FFA, free fatty acid, LCER, DEG, MUFA, education, phosphatidylcholine, chimeric mouse hepatocytes, FAH, SM, sphingomyelin, ALP, alkaline phosphatase, FA, fatty acid, NTBC, Fatty acid, medicine.disease, differentially expressed gene, lactosylceramide, PNPLA3, patatin-like-phospholipase domain-containing protein 3, Lipid metabolism, chemistry, fatty acid, PUFA, hALB, human albumin, TIRF, transgene-free Il2rg-/-/Rag2-/-/Fah, AST, aspartate aminotransferase, CT, confidence transcript, PC, phosphatidylcholine, monounsaturated fatty acid, DEG, differentially expressed gene, MUFA, monounsaturated fatty acid, Immunology and Allergy, MAG, monoacylglycerol, PUFA, polyunsaturated free FA, CE, cholesteryl ester, CER, diacylglycerol, FAH, fumarylacetoacetate hydrolase, Fatty liver, SM, chimeric human hepatocytes, hepatocellular carcinoma, CBPEGs, cholesterol biosynthesis pathway enzyme genes, CE, MAG, LPC, patatin-like-phospholipase domain-containing protein 3, triacylglycerol, LPE, alkaline phosphatase, sterol regulatory element-binding protein, Polyunsaturated fatty acid, Research Article, CT, NAFLD, non-alcoholic fatty liver disease, FA, HCER, TAG, triacylglycerol, fumarylacetoacetate hydrolase, monoacylglycerol, alanine aminotransferase, Population, cholesterol biosynthesis pathway enzyme genes, Biology, SREBP, PI, phosphatidylinositol, sphingomyelin, lysophosphatidylcholine, WD, ALT, alanine aminotransferase, high confidence transcriptional target, Internal Medicine, medicine, CBPEGs, ceramide, hALB, LCER, lactosylceramide, normal chow, AST, polyunsaturated free FA, WD, Western-type diet, PNPLA3, 030304 developmental biology, Hepatitis, LPC, lysophosphatidylcholine, Hepatology, DAG, non-alcoholic fatty liver disease, NTBC, nitisinone, CMHs, GGT, HCT, high confidence transcriptional target, phosphatidylethanolamine, TAG, Cancer research, CHHs, chimeric human hepatocytes, ALP, Liver function, NC, CER, ceramide, HCC, hepatocellular carcinoma, FFA, DAG, diacylglycerol, Non-alcoholic fatty liver disease

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b0393a5555874a5526c491b8421dfdTest
https://escholarship.org/uc/item/2hg8h2x9Test

المؤلفون: Irene Locatelli, Francesco Vizzutti, N. Navari, Emanuele Albano, Alessandra Caligiuri, Erica Novo, Maurizio Parola, Massimo Pinzani, W. Delogu, E. Zamara, Fabio Marra, Salvatore Sutti, S. Galastri, E. Vivoli, A. Provenzano, Stefano Milani

المصدر: Clinical Science (London, England : 1979)
Clinical Science
Clinical Science; Vol 123

مصطلحات موضوعية: Liver Cirrhosis, HNE, 4-hydroxynonenal, IFN-γ, interferon-γ, Adipose tissue, AST, aspartate aminotransferase, iNOS, inducible NO synthase, chemistry.chemical_compound, Mice, 0302 clinical medicine, CC chemokine ligand 2, Fibrosis, Transforming Growth Factor beta, cytokine, Chemokine CCL2, liver fibrosis, Mice, Knockout, 0303 health sciences, TIMP-1, tissue inhibitor of metalloproteinases-1, Mice, Inbred BALB C, Fatty liver, CCL2, CC chemokine ligand 2, General Medicine, MGL1, macrophage galactose-type C-type lectin 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, TNFα, tumour necrosis factor α, 030211 gastroenterology & hepatology, non-alcoholic steatohepatitis, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, Biology, S2, Collagen Type I, 03 medical and health sciences, ROS, reactive oxygen species, Species Specificity, Internal medicine, TGF-β, transforming growth factor-β, medicine, Hepatic Stellate Cells, Animals, Sirius Red, 030304 developmental biology, KO, knockout, Tissue Inhibitor of Metalloproteinase-1, Macrophages, chemokine, medicine.disease, WT, wild-type, Dietary Fats, IL, interleukin, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Alanine transaminase, Immunology, CCR2, CC chemokine receptor 2, Hepatic stellate cell, biology.protein, Steatosis, Steatohepatitis, RT, real-time, FAM, 6-carboxyfluorescein, MCD diet, methionine/choline-deficient diet

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6301da5ba54f78553e0c47b589df9625Test
http://europepmc.org/articles/PMC3369401Test

المؤلفون: Shannon M. Bailey, Heather B. Eccleston, David W. Kraus, Victor M. Darley-Usmar, Sudheer K. Mantena, Jeannette E. Doeller, Kelly K. Andringa, Adrienne L. King, Denty Paul Vaughn, Gary A. Abrams

المصدر: Biochemical Journal

مصطلحات موضوعية: Male, Bioenergetics, Nitric Oxide Synthase Type II, Mitochondria, Liver, Mitochondrion, medicine.disease_cause, Biochemistry, JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol carbo-cyanine iodide, chemistry.chemical_compound, Mice, 0302 clinical medicine, HFD, high fat diet, cytochrome c oxidase, 3-NT, 3-nitrotyrosine, Hypoxia, Membrane Potential, Mitochondrial, 0303 health sciences, Fatty liver, CYP2E1, cytochrome P450 2E1, Cytochrome P-450 CYP2E1, 3. Good health, mitochondria, FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone, 030220 oncology & carcinogenesis, iNOS, inducible nitric oxide synthase, non-alcoholic steatohepatitis, RCR, respiratory control ratio, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, Cellular respiration, NASH, non-alcoholic steatohepatitis, Cell Respiration, Biology, liver, Nitric Oxide, Nitric oxide, PAPA NONOate, 1-propanamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazino), DAB, diaminobenzidine, RNS, reactive nitrogen species, Mitochondrial Proteins, 03 medical and health sciences, ROS, reactive oxygen species, Internal medicine, medicine, Animals, Molecular Biology, Reactive nitrogen species, 030304 developmental biology, nutritional and metabolic diseases, Cell Biology, medicine.disease, Dietary Fats, Fatty Liver, Mice, Inbred C57BL, Oxidative Stress, Endocrinology, chemistry, Tyrosine, Steatohepatitis, Oxidative stress, DAPI, 4′,6-diamidino-2-phenylindole

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8ad50b2a6a6f4a72113fc86354941bTest
http://europepmc.org/articles/PMC2637578Test

المؤلفون: Felix Stickel, Maria L. Balmer, Jeannine Joneli, Wolfgang Thormann, Alain M. Schoepfer, Jean-François Dufour

المصدر: Clinical Science (London, England : 1979)
Clinical science (London England : 1979)

مصطلحات موضوعية: Liver Cirrhosis, Male, Cirrhosis, BMI, body mass index, AST, aspartate aminotransferase, Serum Hyaluronic Acid, Chronic liver disease, Body Mass Index, Liver disease, 0302 clinical medicine, Blood serum, hepatic fibrosis, AdipoR, adiponectin receptor, Prospective Studies, Hyaluronic Acid, 2. Zero hunger, 0303 health sciences, Anthropometry, Liver Diseases, Fatty liver, General Medicine, Middle Aged, 3. Good health, TG, triacylglycerol, HOMA, homoeostasis model assessment, Elasticity Imaging Techniques, 030211 gastroenterology & hepatology, Female, non-alcoholic fatty liver disease (NAFLD), Research Article, Adult, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ANCOVA, analysis of covariance, NASH, non-alcoholic steatohepatitis, S7, S3, metabolic syndrome, Bile Acids and Salts, Diagnosis, Differential, 03 medical and health sciences, Sex Factors, Internal medicine, ALT, alanine aminotransferase, medicine, Humans, 030304 developmental biology, Adiponectin, adiponectin, business.industry, cirrhosis, nutritional and metabolic diseases, chronic liver disease, medicine.disease, Fatty Liver, Endocrinology, Chronic Disease, Steatohepatitis, business, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57760eaf2f7c8755862836a259985d38Test
https://pubmed.ncbi.nlm.nih.gov/20524936Test

المؤلفون: Mariuca Vasa-Nicotera, Elsa Solà, Juan José Lozano, Pau Sancho-Bru, Sara Fernández, Jonel Trebicka, Elisa Pose, Pere Ginès, Pedro Castro, Delia Blaya, Julia Sidorova, Robert Schierwagen, Joan Caballería, Mar Coll, Christian Jansen, Isabel Graupera

المصدر: JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100233-(2021)
Blaya, D, Pose, E, Coll, M, Lozano, J J, Graupera, I, Schierwagen, R, Jansen, C, Castro, P, Fernandez, S, Sidorova, J, Vasa-Nicotera, M, Solà, E, Caballería, J, Trebicka, J, Ginès, P & Sancho-Bru, P 2021, ' Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure ', JHEP Reports, vol. 3, no. 2, 100233 . https://doi.org/10.1016/j.jhepr.2021.100233Test

مصطلحات موضوعية: medicine.medical_specialty, Cirrhosis, NASH, non-alcoholic steatohepatitis, Encephalopathy, AST, aspartate aminotransferase, Disease, FoxO, forkhead box O, Chronic liver disease, Gastroenterology, Non-coding RNAs, CXCL10, C-X-C motif chemokine ligand 10, MELD, model for end-stage liver disease, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Model for End-Stage Liver Disease, ALT, alanine aminotransferase, TIPS, transjugular intrahepatic portosystemic shunt, Internal medicine, Internal Medicine, medicine, Immunology and Allergy, Decompensation, lcsh:RC799-869, EF CLIF, European Foundation for the Study of Chronic Liver Failure, INR, International Normalised Ratio, TGF, transforming growth factor, 030304 developmental biology, PBMCs, peripheral blood mononuclear cells, PCA, principal component analysis, 0303 health sciences, LDH, lactate dehydrogenase, Hepatology, business.industry, medicine.disease, 3. Good health, Circulating MicroRNA, ACLF, acute-on-chronic liver failure, 030220 oncology & carcinogenesis, lcsh:Diseases of the digestive system. Gastroenterology, qPCR, quantitative PCR, business, Liver decompensation, Biomarkers, MAPK, mitogen-activated protein kinase, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d4e48212cb48cff68c240ced3c4227Test