المؤلفون: Alice P. Sowton, Andrew J. Murray, Simon James Tunster, Erica D. Watson, Ben D. McNally, Nisha Padmanabhan, Julian L. Griffin, Antonio Murgia, Aisha Yusuf

المساهمون: Medical Research Council, Medical Research Council (MRC), Sowton, Alice [0000-0002-3718-7783], Tunster, Simon [0000-0002-2242-9452], Murray, Andrew [0000-0002-0929-9315], Watson, Erica [0000-0003-4496-2271], Apollo - University of Cambridge Repository, Watson, Erica D [0000-0003-4496-2271]

المصدر: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 23, Iss, Pp-(2020)

مصطلحات موضوعية: CE, cholesteryl-ester, LC-MS, liquid chromatography-mass spectrometry, 5-methyl-THF, 5-methyltetrahydofolate, OXPHOS, oxidative phosphorylation, G6pc, glucose 6-phophastase gene, PG, phosphatidylglycerol, 0601 Biochemistry and Cell Biology, Gyg, glycogenin gene, PIP, phosphatidylinositol phosphate(s), Cebpa, CCAAT/enhancer binding protein (C/EBP), alpha gene, chemistry.chemical_compound, Isca1, iron‑sulfur cluster assembly 1 gene, PC, phosphatidylcholine, 0302 clinical medicine, Endocrinology, Nonalcoholic fatty liver disease, One‑carbon metabolism, PA, phosphatidic acid, lcsh:QH301-705.5, 0303 health sciences, lcsh:R5-920, biology, Glycogen, FCCP, p-trifluoromethoxyphenyl hydrazine, 030305 genetics & heredity, SAM, S-adenosylmethionine, Mthfr, methylenetetrahydrofolate reductase gene, Mtr, methionine synthase gene (also MS), PS, phosphatidylserine, 3. Good health, PL, phospholipid, Gsk3, glycogen synthase kinase gene, RIPA, Radioimmunoprecipitation assay, Agl, amylo-alpha-1,6-glucosidase,4-alpha-glucanotransferase gene, Ndufs, NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene, Liver metabolism, Bhmt, betaine-homocysteine S-methyltransferase gene, Hepatic fuel storage, lcsh:Medicine (General), Gbe1, glycogen branching enzyme 1 gene, Research Paper, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, TAG, triacylglycerol, NASH, non-alcoholic steatohepatitis, Cer, ceramide, PE, phosphatidylethanolamine, PI, phosphatidylinositol, 03 medical and health sciences, Internal medicine, FFA, free fatty acid, Genetics, medicine, JO2, oxygen flux, Glycogen synthase, GSK3A, Molecular Biology, Myc, myelocytomatosis oncogene, 0604 Genetics, Methionine, LPC, lysophosphatidylcholine, SM, sphingomyelin, Ddit3, DNA damage inducible transcript 3 gene, SAH, S-adenosylhomocysteine, Lipid metabolism, (Methionine synthase) reductase, Gys2, glycogen synthase 2 gene, Ugp2, UDP-glucose pyrophophorylase 2 gene, medicine.disease, MTRR, HOAD, 3-hydoxyacyl-CoA dehydrogenase, BCA, bicinchoninic acid, Mtrr, methionine synthase reductase gene (also MSR), chemistry, lcsh:Biology (General), gt, gene-trap, Lipidomics, biology.protein, Mitochondrial function, PAS, periodic acid Schiff, DAG, diacylglycerol, 030217 neurology & neurosurgery, ETS, electron transport system

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5de79e1f7ef67cef5ce425b58d812c6Test
http://hdl.handle.net/10044/1/82233Test

المؤلفون: Xuemei Wang, Wei Kong, Yuanyuan Pang, Lulu Sun, Huiying Liu, Bo Liu, Min Ye, Qing Wu, George Liu, Changtao Jiang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 4, Pp 702-710 (2019)

مصطلحات موضوعية: eWAT, epididymal white adipose tissue, Metabolic disorders, White adipose tissue, Gut flora, UPLC–MS/MS, ultra performance liquid chromatography–tandem mass spectrometry, 0302 clinical medicine, HFD, high fat diet, AST, aspartate transaminase, GCA, glycocholic acid, VLDL, very low-density lipoprotein, TβMCA, General Pharmacology, Toxicology and Pharmaceutics, LCA, lithocholic acid, CAPE, caffeic acid phenethyl ester, TβMCA, tauro-β-muricholic acid, 0303 health sciences, CA, cholic acid, GCDCA, glycochenodeoxycholic acid, CYP7B1, biology, Bile acid, Chemistry, sWAT, subcutaneous white adipose tissue, FGF15/19, fibroblast growth factor 15/19, TG, triglycerides, CETP, cholesterol ester transfer protein, CYP7A1, cytochrome P450 family 7 subfamily A member 1, FXR, 030220 oncology & carcinogenesis, GTT, glucose tolerance test, BSH, bile acid hydrolase, CYP7B1, cytochrome P450 family 7 subfamily B member 1, medicine.medical_specialty, Original article, NAFLD, non-alcoholic fatty liver disease, PBA/SBA, primary bile acids to secondary bile acids, medicine.drug_class, NASH, non-alcoholic steatohepatitis, TCA, taurocholic acid, Hamster, ALT, alanine amino-transferase, CYP8B1, cytochrome P450 family 8 subfamily B member 1, T2D, type 2 diabetes, Gut microbiota, AUC, area under curve, digestive system, CYP27A1, cytochrome P450 family 27 subfamily A member 1, UDCA, ursodeoxycholic acid, CDCA, chenodeoxycholic acid, 03 medical and health sciences, Insulin resistance, FXR, farnesoid X receptor, Internal medicine, medicine, ApoB, apolipoprotein B, 030304 developmental biology, ITT, insulin tolerance test, BAs, bile acids, lcsh:RM1-950, medicine.disease, biology.organism_classification, TC, total cholesterol, lcsh:Therapeutics. Pharmacology, Endocrinology, DCA, deoxycholic acid, H&E, hematoxylin and eosin, Farnesoid X receptor, Steatosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc312ddccc0b191b5f0414f6cd3240aTest
https://pubmed.ncbi.nlm.nih.gov/31384531Test

المؤلفون: Alexandra K. Leamy, Jamey D. Young, Robert A. Egnatchik, Masakazu Shiota, David A. Jacobson

المصدر: Molecular Metabolism

مصطلحات موضوعية: NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, SERCA, NASH, non-alcoholic steatohepatitis, SFA, saturated fatty acid, chemistry.chemical_element, Biology, Calcium, Mitochondrion, medicine.disease_cause, PA, palmitate, Calcium in biology, PI, propidium iodide, 03 medical and health sciences, chemistry.chemical_compound, H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate, ROS, reactive oxygen species, 0302 clinical medicine, BAPTA, Fatty liver, Internal medicine, CAC, citric acid cycle, FFA, free fatty acid, MUFA, monounsaturated fatty acid, medicine, Molecular Biology, MFA, metabolic flux analysis, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, APE, atom percent enrichment, Metabolic flux analysis, Cell Biology, SERCA, sarcoplasmic-endoplasmic reticulum calcium ATPase, 3. Good health, Endocrinology, chemistry, Lipotoxicity, Oxidative stress, OA, oleate, 030220 oncology & carcinogenesis, Original Article, BSA, bovine serum albumin, GC–MS, gas chromatography–mass spectrometry, ER stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8abb056af369ca34e6c97f53de9251Test

المؤلفون: Montserrat Marí, José C. Fernández-Checa, Anna Colell, Albert Morales, Carmen García-Ruiz

المصدر: Redox Biology, Vol 3, Iss C, Pp 100-108 (2014)
Redox Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Alcoholic liver disease, OXPHOS, oxidative phosphorylation, Clinical Biochemistry, Mitochondria, Liver, Mitochondrial GSH, Mitochondrion, medicine.disease_cause, Biochemistry, AH, alcoholic hepatitis, 0302 clinical medicine, GSH, glutathione, FFA, free fatty acids, Acid sphingomyelinase, TNF, tumor necrosis factor, lcsh:QH301-705.5, 0303 health sciences, lcsh:R5-920, CYP2E1, cytochrome P450 2E1, ASMase, acid sphingomyelinase, TG, triglycerides, Endoplasmic Reticulum Stress, Glutathione, 3. Good health, Cell biology, MRC, mitochondrial respiratory chain, Mitochondrial cholesterol, Cholesterol, Sphingomyelin Phosphodiesterase, Mitochondrial respiratory chain, ASH, alcoholic steatohepatitis, Lipotoxicity, 030211 gastroenterology & hepatology, ER stress, lcsh:Medicine (General), Research Paper, medicine.medical_specialty, ALD, alcoholic liver disease, mGSH, mitochondrial GSH, SH, steatohepatitis, NASH, non-alcoholic steatohepatitis, Oxidative phosphorylation, Biology, ER, endoplasmic reticulum, 03 medical and health sciences, ROS, reactive oxygen species, SOD, superoxide dismutase, Internal medicine, medicine, Animals, Humans, Liver Diseases, Alcoholic, 030304 developmental biology, Endoplasmic reticulum, Organic Chemistry, medicine.disease, Endocrinology, lcsh:Biology (General), Unfolded protein response, NAFLD, nonalcoholic fatty liver disease, Reactive Oxygen Species, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef38e86f50b5350b0acad0cb4e609e11Test
http://www.sciencedirect.com/science/article/pii/S2213231714001049Test

المؤلفون: Maelle Morgan, Barbara Sigalla, J Soeda, Chad McKee, Tania Roskams, Esra Asilmaz, Jude A. Oben, Nicoletta Sinelli

المصدر: Biochemical and Biophysical Research Communications

مصطلحات موضوعية: Male, Cirrhosis, Apoptosis, HPC, hepatic progenitor cell, Biochemistry, Choline, Mice, chemistry.chemical_compound, 0302 clinical medicine, Ethionine, Liver injury, 0303 health sciences, Stem Cells, Alanine Transaminase, Fas receptor, Propranolol, 3. Good health, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Hepatocyte, PRZ, prazosin, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, Fas Ligand Protein, NASH, non-alcoholic steatohepatitis, Adrenergic beta-Antagonists, Biophysics, Biology, Article, 03 medical and health sciences, Internal medicine, Receptors, Adrenergic, beta, medicine, Animals, Molecular Biology, 030304 developmental biology, L-Lactate Dehydrogenase, Tumor Necrosis Factor-alpha, PRL, propranolol, OC, oval cell, Antagonist, Cell Biology, medicine.disease, Culture Media, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, Endocrinology, chemistry, Sympathetic nervous system, Hepatocytes, Hepatic stellate cell, Steatohepatitis, Non-alcoholic fatty liver disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f003a82453155f5ae4f332cad7b55123Test
https://doi.org/10.1016/j.bbrc.2013.07.005Test

المؤلفون: Irene Locatelli, Francesco Vizzutti, N. Navari, Emanuele Albano, Alessandra Caligiuri, Erica Novo, Maurizio Parola, Massimo Pinzani, W. Delogu, E. Zamara, Fabio Marra, Salvatore Sutti, S. Galastri, E. Vivoli, A. Provenzano, Stefano Milani

المصدر: Clinical Science (London, England : 1979)
Clinical Science
Clinical Science; Vol 123

مصطلحات موضوعية: Liver Cirrhosis, HNE, 4-hydroxynonenal, IFN-γ, interferon-γ, Adipose tissue, AST, aspartate aminotransferase, iNOS, inducible NO synthase, chemistry.chemical_compound, Mice, 0302 clinical medicine, CC chemokine ligand 2, Fibrosis, Transforming Growth Factor beta, cytokine, Chemokine CCL2, liver fibrosis, Mice, Knockout, 0303 health sciences, TIMP-1, tissue inhibitor of metalloproteinases-1, Mice, Inbred BALB C, Fatty liver, CCL2, CC chemokine ligand 2, General Medicine, MGL1, macrophage galactose-type C-type lectin 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, TNFα, tumour necrosis factor α, 030211 gastroenterology & hepatology, non-alcoholic steatohepatitis, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, Biology, S2, Collagen Type I, 03 medical and health sciences, ROS, reactive oxygen species, Species Specificity, Internal medicine, TGF-β, transforming growth factor-β, medicine, Hepatic Stellate Cells, Animals, Sirius Red, 030304 developmental biology, KO, knockout, Tissue Inhibitor of Metalloproteinase-1, Macrophages, chemokine, medicine.disease, WT, wild-type, Dietary Fats, IL, interleukin, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Alanine transaminase, Immunology, CCR2, CC chemokine receptor 2, Hepatic stellate cell, biology.protein, Steatosis, Steatohepatitis, RT, real-time, FAM, 6-carboxyfluorescein, MCD diet, methionine/choline-deficient diet

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6301da5ba54f78553e0c47b589df9625Test
http://europepmc.org/articles/PMC3369401Test

المؤلفون: Shannon M. Bailey, Heather B. Eccleston, David W. Kraus, Victor M. Darley-Usmar, Sudheer K. Mantena, Jeannette E. Doeller, Kelly K. Andringa, Adrienne L. King, Denty Paul Vaughn, Gary A. Abrams

المصدر: Biochemical Journal

مصطلحات موضوعية: Male, Bioenergetics, Nitric Oxide Synthase Type II, Mitochondria, Liver, Mitochondrion, medicine.disease_cause, Biochemistry, JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol carbo-cyanine iodide, chemistry.chemical_compound, Mice, 0302 clinical medicine, HFD, high fat diet, cytochrome c oxidase, 3-NT, 3-nitrotyrosine, Hypoxia, Membrane Potential, Mitochondrial, 0303 health sciences, Fatty liver, CYP2E1, cytochrome P450 2E1, Cytochrome P-450 CYP2E1, 3. Good health, mitochondria, FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone, 030220 oncology & carcinogenesis, iNOS, inducible nitric oxide synthase, non-alcoholic steatohepatitis, RCR, respiratory control ratio, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, Cellular respiration, NASH, non-alcoholic steatohepatitis, Cell Respiration, Biology, liver, Nitric Oxide, Nitric oxide, PAPA NONOate, 1-propanamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazino), DAB, diaminobenzidine, RNS, reactive nitrogen species, Mitochondrial Proteins, 03 medical and health sciences, ROS, reactive oxygen species, Internal medicine, medicine, Animals, Molecular Biology, Reactive nitrogen species, 030304 developmental biology, nutritional and metabolic diseases, Cell Biology, medicine.disease, Dietary Fats, Fatty Liver, Mice, Inbred C57BL, Oxidative Stress, Endocrinology, chemistry, Tyrosine, Steatohepatitis, Oxidative stress, DAPI, 4′,6-diamidino-2-phenylindole

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8ad50b2a6a6f4a72113fc86354941bTest
http://europepmc.org/articles/PMC2637578Test

المؤلفون: Felix Stickel, Maria L. Balmer, Jeannine Joneli, Wolfgang Thormann, Alain M. Schoepfer, Jean-François Dufour

المصدر: Clinical Science (London, England : 1979)
Clinical science (London England : 1979)

مصطلحات موضوعية: Liver Cirrhosis, Male, Cirrhosis, BMI, body mass index, AST, aspartate aminotransferase, Serum Hyaluronic Acid, Chronic liver disease, Body Mass Index, Liver disease, 0302 clinical medicine, Blood serum, hepatic fibrosis, AdipoR, adiponectin receptor, Prospective Studies, Hyaluronic Acid, 2. Zero hunger, 0303 health sciences, Anthropometry, Liver Diseases, Fatty liver, General Medicine, Middle Aged, 3. Good health, TG, triacylglycerol, HOMA, homoeostasis model assessment, Elasticity Imaging Techniques, 030211 gastroenterology & hepatology, Female, non-alcoholic fatty liver disease (NAFLD), Research Article, Adult, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ANCOVA, analysis of covariance, NASH, non-alcoholic steatohepatitis, S7, S3, metabolic syndrome, Bile Acids and Salts, Diagnosis, Differential, 03 medical and health sciences, Sex Factors, Internal medicine, ALT, alanine aminotransferase, medicine, Humans, 030304 developmental biology, Adiponectin, adiponectin, business.industry, cirrhosis, nutritional and metabolic diseases, chronic liver disease, medicine.disease, Fatty Liver, Endocrinology, Chronic Disease, Steatohepatitis, business, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57760eaf2f7c8755862836a259985d38Test
https://pubmed.ncbi.nlm.nih.gov/20524936Test