المؤلفون: Esther Wong, Stephen D Raj, David Y. Fann, Brian K. Kennedy

المصدر: Medicinal research reviewsREFERENCES. 41(6)

مصطلحات موضوعية: Aging, Longevity, Computational biology, Resveratrol, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Senotherapeutics, Drug Discovery, Autophagy, Humans, Repurposing, 030304 developmental biology, Pharmacology, 0303 health sciences, Biological Products, Geroscience, Drug discovery, Trehalose, Urolithin, Spermidine, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine

الوصف: Over the past decade, significant attention has been given to repurposing Food and Drug Administration approved drugs to treat age-related diseases. In contrast, less consideration has been given to natural bioactive compounds. Consequently, there have been limited attempts to translate these compounds. Autophagy is a fundamental biological pathway linked to aging, and numerous strategies to enhance autophagy have been shown to extend lifespan. Interestingly, there are a number of natural products that are reported to modulate autophagy, and here we describe a number of them that activate autophagy through diverse molecular and cellular mechanisms. Among these, Urolithin A, Spermidine, Resveratrol, Fatty Acids and Phospholipids, Trehalose and Lithium are featured in detail. Finally, we outline possible strategies to optimise and increase the translatability of natural products, with the overall aim of delaying the ageing process and improving human healthspan.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2ba10246597bd3bc75520bd21a89c3Test
https://pubmed.ncbi.nlm.nih.gov/33973253Test

المؤلفون: Melissa A. Simon, Laura S. Tom, Ivy Leung, Shaneah Taylor, Esther Wong, Dan P. Vicencio, XinQi Dong

المصدر: Health Equity, Vol 2, Iss 1, Pp 182-192 (2018)
Health Equity

مصطلحات موضوعية: Gerontology, Health (social science), Chinatown, elderly, 03 medical and health sciences, Social support, 0302 clinical medicine, 5. Gender equality, Health Information Management, Health care, 030212 general & internal medicine, Chinese americans, family health, business.industry, lcsh:Public aspects of medicine, Health Policy, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Focus group, 3. Good health, Spouse, 030220 oncology & carcinogenesis, Community health, Original Article, business, Psychology, immigrant health, qualitative research, Qualitative research

الوصف: Purpose: Healthcare utilization and health-seeking behaviors of Chinese American immigrant women may be influenced by longstanding cultural perspectives of family roles and relationships. An understanding of Chinese immigrant women's perceptions of family social support in health and how these beliefs manifest in healthcare utilization and help-seeking behaviors is critical to the development of culturally appropriate health interventions. Focusing on a sample of Chinese women in Chicago's Chinatown, this qualitative study seeks to describe women's attitudes and beliefs about spouse and adult children's involvement in women's health and healthcare. Methods: We conducted six focus groups among 56 Chinese-speaking adult women in Chicago's Chinatown between July and August 2014. Focus groups were transcribed, coded, and analyzed for emergent themes. Results: Women reported that their adult children supported their health and healthcare utilization by helping them overcome language and transportation barriers, making and supporting decisions, and providing informational and instrumental support related to diet and nutrition. Women viewed these supports with mixed expectations of filial piety, alongside preferences to limit dependency and help-seeking because of concern and emotional distress regarding burdening adult children. Women's expectations of the spouse involvement in their healthcare were low and were shaped by avoidance of family conflict. Conclusion: Findings inform opportunities for the development of culturally appropriate interventions to enhance Chinese immigrant women's health and healthcare. These include patient navigation/community health worker programs to promote self-management of healthcare and family-centered strategies for enhancing family social support structures and reducing family conflict.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab7513a4f417b034f299bd793868e03Test
https://doi.org/10.1089/heq.2017.0062Test

المؤلفون: Valerie Chun Ling Lin, Natasa Bajalovic, Esther Wong, Sijie Tan

المساهمون: School of Biological Sciences, Yong Loo Lin School of Medicine, National University of Singapore

المصدر: Experimental Cell Research. 382:111433

مصطلحات موضوعية: Transcriptional Activation, 0301 basic medicine, Progesterone receptor B, Breast Neoplasms, Adenocarcinoma, Biology, Promegestone, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Protein Interaction Mapping, Breast Cancer, Progesterone receptor, Gene expression, Autophagy, Humans, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Autophagosomes, Biological sciences [Science], Cell Biology, Recombinant Proteins, Neoplasm Proteins, Cell biology, Gene Expression Regulation, Neoplastic, Protein Transport, 030104 developmental biology, MCF-7, 030220 oncology & carcinogenesis, Cancer cell, MCF-7 Cells, TFEB, Female, Lysosomes, Receptors, Progesterone, Microtubule-Associated Proteins, Nuclear localization sequence, Signal Transduction

الوصف: Autophagy is an evolutionary conserved, self-eating process that targets cellular constituents for lysosomal degradation. Transcription factor EB (TFEB) is a master regulator of autophagy by inducing the expression of genes involved in autophagic and lysosomal degradation. In breast cancer, ligand-activated progesterone receptor has been reported to influence cancer development by manipulating the autophagy pathway. However, understanding of the mechanism that underlies this autophagic response remains limited. Herein, we report that prolonged treatment with progestin R5020 upregulates autophagy in MCF-7 human breast cancer cells via a novel interplay between progesterone receptor B (PRB) and TFEB. R5020 upregulates TFEB gene expression and protein levels in a PRB-dependent manner. Additionally, R5020 enhances the co-recruitment of PRB and TFEB to each other to facilitate TFEB nuclear localization. Once in the nucleus, TFEB induces the expression of autophagy and lysosomal genes to potentiate autophagy. Together, our findings highlight a novel functional connection between ligand-activated PRB and TFEB to modulate autophagy in MCF-7 breast cancer cells. As breast cancer development is controlled by autophagy, the progestin-PRB-TFEB transduction pathway warrants future attention as a potential therapeutic target in cancer therapy. Ministry of Education (MOE) This work is supported by Singapore Ministry of Education Academic Research Fund Tier 2, MOE2014-T2-2-125.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90eabe0174364bac54ba7cda6c1f101fTest
https://doi.org/10.1016/j.yexcr.2019.05.014Test

المؤلفون: Laura S. Tom, Melissa A. Simon, Ivy Leung, Eileen Knightly, XinQi Dong, Daniel P. Vicencio, Karen Ortigara, Ann Yau, Esther Wong

المصدر: Health Services Insights, Vol 12 (2019)
Health Services Insights

مصطلحات موضوعية: Asian American, cervical cancer, Chinatown, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, Nursing, Asian americans, Health care, medicine, Program adaptation, In patient, 030212 general & internal medicine, Original Research, Cervical cancer, implementation science, lcsh:R5-920, Chinese, business.industry, lcsh:Public aspects of medicine, Health Policy, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, medicine.disease, 3. Good health, patient navigation, 030220 oncology & carcinogenesis, Health care reform, lcsh:Medicine (General), Psychology, business

الوصف: Background: As health care reform continues within the United States, navigators may play increasingly diverse and vital roles across the health care continuum. The growing interest in patient navigation programs for underserved populations calls for detailed descriptions of intervention components to facilitate implementation and dissemination efforts. Methods: In Chicago’s Chinatown, Chinese immigrant women face language, cultural, and access barriers in obtaining breast and cervical cancer screening and follow-up. These barriers spurred the research partnership between Northwestern University, the Chinese American Service League, Mercy Hospital & Medical Center, and Rush University Medical Center to formalize the Chinatown Patient Navigation Collaborative for adapting and implementing previously developed patient navigation models. Results: In this report, we describe the adaptation of patient navigation to build the Chinatown Patient Navigation Collaborative’s community-based patient navigation program for breast and cervical cancer. We offer insights into the roles of community patient navigators in safety net hospital and underserved Chinese immigrant communities, and describe implications for patient navigation initiatives to maximize community benefits by improving access to health care for vulnerable populations. Conclusions: Our adaptation and implementation of a patient navigation intervention in Chicago’s Chinatown illustrates promising approaches for future navigator research.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eb09d7a27fc81b2c7b0a84ef0e12ffTest
https://doi.org/10.1177/1178632919841376Test