A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle
| العنوان: | A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle |
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| المؤلفون: | Junzhi Lin, Xue Han, Run-Chun Xu, Chaomei Fu, Ding-Kun Zhang, Li Han, Xi Xiong, Hong Jiang, Ya-Nan He, Ming Yang |
| المصدر: | Acta Pharmaceutica Sinica B, Vol 8, Iss 2, Pp 209-217 (2018) Acta Pharmaceutica Sinica. B |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Taste, Electronic tongue, 02 engineering and technology, 030226 pharmacology & pharmacy, Sensory analysis, 03 medical and health sciences, 0302 clinical medicine, Quantification, Evaluation methods, Medicine, Human sensory evaluation, General Pharmacology, Toxicology and Pharmaceutics, Animal ethology, Quinine, business.industry, lcsh:RM1-950, Bitter, Pattern recognition, Chinese herbs, Two-bottle preference test, 021001 nanoscience & nanotechnology, lcsh:Therapeutics. Pharmacology, Assessment methods, Original Article, Disease prevention, Artificial intelligence, 0210 nano-technology, business |
| الوصف: | Traditional Chinese herbs (TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major challenge to establish a quantitative detection technique that is objective, authentic and sensitive. Based on the two-bottle preference test (TBP), we proposed a novel quantitative strategy using a standardized animal test and a unified quantitative benchmark. To reduce the difference of results, the methodology of TBP was optimized. The relationship between the concentration of quinine and animal preference index (PI) was obtained. Then the PI of TCH was measured through TBP, and bitterness results were converted into a unified numerical system using the relationship of concentration and PI. To verify the authenticity and sensitivity of quantified results, human sensory testing and electronic tongue testing were applied. The quantified results showed a good discrimination ability. For example, the bitterness of Coptidis Rhizoma was equal to 0.0579 mg/mL quinine, and Nelumbinis Folium was equal to 0.0001 mg/mL. The validation results proved that the new assessment method for TCH was objective and reliable. In conclusion, this study provides an option for the quantification of bitterness and the evaluation of taste masking effects. Graphical abstract A quantitative strategy for bitterness of traditional Chinese herbs was developed using a standardized animal test and a unified quantitative benchmark in this study. It provides an option for the quantification of bitterness and the evaluation of taste masking effects.fx1 |
| اللغة: | English |
| تدمد: | 2211-3835 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0caf36259d0e7296c12284be10ee4aeTest http://www.sciencedirect.com/science/article/pii/S2211383517302563Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e0caf36259d0e7296c12284be10ee4ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22113835 |
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