المؤلفون: Min-Sik Park, Byung Gon Kim, Cheol Ho Lee, Jeong-Hee Choi, Jae Yup Jung, Sang-Min Lee, Asif Raza

المصدر: ACS Applied Materials & Interfaces. 13:7161-7170

مصطلحات موضوعية: Materials science, Composite number, 02 engineering and technology, Electrolyte, 010402 general chemistry, 021001 nanoscience & nanotechnology, Microstructure, 01 natural sciences, Lithium-ion battery, 0104 chemical sciences, Anode, Chemical engineering, Metal powder, General Materials Science, 0210 nano-technology, Capacity loss, Faraday efficiency

الوصف: Si-based anode materials are considered as potential materials for high-energy lithium-ion batteries (LIBs) with the advantages of high specific capacities and low operating voltages. However, significant initial capacity loss and large volume variations during cycles are the primary restrictions for the practical application of Si-based anodes. Herein, we propose an affordable and scalable synthesis of double-layered SiOx/Mg2SiO4/SiOx composites through the magnesiothermic reduction of micro-sized SiO with Mg metal powder at 750 °C for 2 h. The distinctive morphology and microstructure of the double-layered SiOx/Mg2SiO4/SiOx composite are beneficial as they remarkably improve the reversibility in the first cycle and completely suppress the volume variations during cycling. In our material design, the outermost layer with a highly porous SiOx structure provides abundant active sites by securing a pathway for efficient access to electrons and electrolytes. The inner layer of Mg2SiO4 can constrain the large volume expansion to increase the initial Coulombic efficiency (ICE). Owing to these promising structural features, the composite prepared with a 2:1 molar ratio of SiO to Mg exhibited initial charge and discharge capacities of 1826 and 1381 mA h g-1, respectively, with an ICE of 75.6%. Moreover, it showed a stable cycle performance, maintaining high capacity retention of up to >86.0% even after 300 cycles. The proposed approach provides practical insight into the mass production of advanced anode materials for high-energy LIBs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c7999e239964143bcc0f5b4538506ac1Test
https://doi.org/10.1021/acsami.0c19975Test

المؤلفون: Sadia Tabassam Arif, Fawad Ali Shah, Arooj Mohsin Alvi, Jeong-Sook Park, Cheol Ho Lee, Alam Zeb, Ok-Nam Bae, Ho-Ik Choi, Chang-Wan Lim, Najam us Sahar, Jin-Ki Kim, Namrah Khan, Isra Rana, Seong-Woong Baek, Fakhar ud Din

المصدر: Pharmaceutics
Pharmaceutics, Vol 12, Iss 1184, p 1184 (2020)

مصطلحات موضوعية: Drug, media_common.quotation_subject, enzymes, lcsh:RS1-441, Pharmaceutical Science, 02 engineering and technology, Review, 010402 general chemistry, Bioinformatics, 01 natural sciences, lcsh:Pharmacy and materia medica, recombinant DNA technology, Medicine, Intrinsic instability, media_common, nanocarriers, hormones, business.industry, biopharmaceuticals, vaccines, 021001 nanoscience & nanotechnology, proteins, cytokines, 0104 chemical sciences, Biopharmaceutical, delivery and formulation challenges, monoclonal antibodies, Nanocarriers, 0210 nano-technology, business, Retention time

الوصف: During the past two decades, the clinical use of biopharmaceutical products has markedly increased because of their obvious advantages over conventional small-molecule drug products. These advantages include better specificity, potency, targeting abilities, and reduced side effects. Despite the substantial clinical and commercial success, the macromolecular structure and intrinsic instability of biopharmaceuticals make their formulation and administration challenging and render parenteral delivery as the only viable option in most cases. The use of nanocarriers for efficient delivery of biopharmaceuticals is essential due to their practical benefits such as protecting from degradation in a hostile physiological environment, enhancing plasma half-life and retention time, facilitating absorption through the epithelium, providing site-specific delivery, and improving access to intracellular targets. In the current review, we highlight the clinical and commercial success of biopharmaceuticals and the overall applications and potential of nanocarriers in biopharmaceuticals delivery. Effective applications of nanocarriers for biopharmaceuticals delivery via invasive and noninvasive routes (oral, pulmonary, nasal, and skin) are presented here. The presented data undoubtedly demonstrate the great potential of combining nanocarriers with biopharmaceuticals to improve healthcare products in the future clinical landscape. In conclusion, nanocarriers are promising delivery tool for the hormones, cytokines, nucleic acids, vaccines, antibodies, enzymes, and gene- and cell-based therapeutics for the treatment of multiple pathological conditions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d276eb94e9eb99daa54e306ba6bba79eTest
https://pubmed.ncbi.nlm.nih.gov/33291312Test

المؤلفون: Ho-Ik Choi, Isra Rana, Muhammad Mohsin Ansari, Cheol Ho Lee, Jin-Ki Kim, Muhammad Imran, Fawad Ali Shah, Alam Zeb, Namrah Khan, Fakhar ud Din, Omer Salman Qureshi, Sadia Sarwar

المصدر: Colloids and surfaces. B, Biointerfaces. 194

مصطلحات موضوعية: Lipopolysaccharides, Lipopolysaccharide, 02 engineering and technology, Pharmacology, Duloxetine Hydrochloride, 01 natural sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, In vivo, 0103 physical sciences, Solid lipid nanoparticle, Zeta potential, Animals, Physical and Theoretical Chemistry, Particle Size, Drug Carriers, 010304 chemical physics, biology, Surfaces and Interfaces, General Medicine, 021001 nanoscience & nanotechnology, In vitro, Antidepressive Agents, Rats, body regions, chemistry, biology.protein, Antidepressant, Nanoparticles, Tumor necrosis factor alpha, Cyclooxygenase, 0210 nano-technology, Biotechnology

الوصف: The potential of duloxetine-loaded solid lipid nanoparticles (DLX-SLNs) for enhanced antidepressant activity was investigated in the current study. Nano-template engineering technology was successfully employed for the preparation of DLX-SLNs. In vivo forced swim and tail suspension tests were used to evaluate behavioral changes of rats in lipopolysaccharide-induced depression. The determination of brain-derived neurotropic factor (BDNF) in brain and plasma was carried out using enzyme-linked immunosorbent assay. The incorporation efficiency of optimized DLX-SLNs formulation was found to be 80 % with particle size of 114.5 nm, PDI of 0.29 and zeta potential of -18.2 mV. Powder X-ray diffractometry and differential scanning calorimetry demonstrated sufficient incorporation into lipid matrix and amorphous behavior of DLX. In vitro release profile of DLX-SLNs showed a sustained release achieving a cumulative amount of 52.97 % for 24 h. DLX-SLNs showed a significant decrease in immobility time in forced swim and tail suspension tests. DLX-SLNs increased BDNF levels in plasma and brain after 2 weeks. Immunohistochemistry results demonstrated significant reduction in the expression of tumor necrosis factor-α and cyclooxygenase enzyme-2 in brain. In conclusion, solid lipid nanoparticles can be utilized as a potential carrier for the delivery of antidepressant drugs into the brain.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee556ad053108b942ea3dda4c65cde3Test
https://pubmed.ncbi.nlm.nih.gov/32599505Test

المؤلفون: Yong-Il Ko, Doh C. Lee, Sungho Lee, Yong Chae Jung, Youn-Ki Lee, Han-Ik Joh, Cheol-Ho Lee

المصدر: ACS Catalysis. 8:5221-5227

مصطلحات موضوعية: Tafel equation, biology, Active site, chemistry.chemical_element, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, Sulfur, Catalysis, 0104 chemical sciences, Amorphous solid, Crystallography, chemistry, biology.protein, Cluster (physics), 0210 nano-technology, Hydrogen production

الوصف: [Mo3S13]2– clusters have become known as one of the most efficient catalysts for the hydrogen evolution reaction (HER) because most of the sulfur (S) atoms in the cluster are exposed, resulting in many active sites. However, the origin of the cluster formation and active S sites in the cluster is unknown, hindering the development of efficient catalysts. Herein, the mechanism of the transition from amorphous MoS3 to [Mo3S13]2– clusters is systematically investigated. In addition, the active S sites have been identified by the selective removal of S atoms via low-temperature heat treatment. In summary, we believe that the clusters grow from amorphous MoS3 with apical S atoms, and bridging S atoms are the active HER sites in the [Mo3S13]2– clusters. The clusters deposited on carbon nanotubes exhibited good electrochemical HER activity with a low onset potential of −96 mV, a Tafel slope of 40 mV/decade, and stability for 1000 cycles.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d5721c7ffc0bbae0d9abb3073a8e6a7cTest
https://doi.org/10.1021/acscatal.8b01034Test

المؤلفون: Gil-Seong Kang, Han-Ik Joh, Cheol-Ho Lee, Jun-Seok Yeo, Doh C. Lee, Yong-Jin Noh, Sungho Lee, Seok-In Na, Sae-Mi Park

المصدر: Journal of Industrial and Engineering Chemistry. 61:106-111

مصطلحات موضوعية: Materials science, Organic solar cell, Graphene, General Chemical Engineering, Energy conversion efficiency, Oxide, chemistry.chemical_element, 02 engineering and technology, Manganese, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, law.invention, chemistry.chemical_compound, chemistry, Chemical engineering, law, Work function, Graphite, 0210 nano-technology, Hybrid material

الوصف: Mn3O4 on reduced graphene oxide (r-GO) was easily synthesized by upcycling process of wasting manganese ions which were generated during oxidation reaction from graphite to GO. The yellow-brown GO suspension under acid media before neutralization immediately became black precipitates when the suspension was titrated into the concentrated NaOH solution. The method could convert the wasting manganese ions up to ∼91 wt% to Mn3O4 to optimize work function in a hole transport layer (HTL) for organic solar cells. The hybrid materials exhibited an ideal electronic structure suitable for HTL, leading to the excellent power conversion efficiency of ∼3.23%.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ef97a438e78776234668d1350f59b086Test
https://doi.org/10.1016/j.jiec.2017.12.006Test

المؤلفون: Youn-Ki Lee, Cheol-Ho Lee, Han-Ik Joh, Doh C. Lee, Geun Seok Chai, Sungho Lee, Gil-Seong Kang

المصدر: Macromolecular Research. 25:1158-1162

مصطلحات موضوعية: inorganic chemicals, Materials science, Polymers and Plastics, General Chemical Engineering, Catalyst support, chemistry.chemical_element, Nanochemistry, 02 engineering and technology, 010402 general chemistry, Platinum nanoparticles, 01 natural sciences, Catalysis, Crystallinity, Materials Chemistry, medicine, Composite material, organic chemicals, Organic Chemistry, 021001 nanoscience & nanotechnology, Durability, 0104 chemical sciences, Chemical engineering, chemistry, 0210 nano-technology, Platinum, Activated carbon, medicine.drug

الوصف: Highly durable platinum (Pt) catalysts for oxygen reduction reaction (ORR) were fabricated using pulverized isotropic pitch based activated carbon fibers as catalyst supports. We controlled the textural and structural properties of catalyst support by heat-treatment with various temperatures of 900, 1200, 1500, and 2000 °C. Crystallinity of the catalyst supports increased with increasing heat-treatment temperature, leading to an increase of conductivity. In addition, the catalytic activity and durability increased and the catalyst using carbon supports heat-treated at 1200 °C showed a comparable performance and superior durability to those of a commercial catalyst. It is suggested that an increase in crystallinity was attributed to prevent elimination of Pt and carbon support, which led to less degradation of catalytic activity and durability for ORR. This work showed the possibility of pitch based activated carbon fibers as a highly durable catalyst support.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::dd107a5dfccb6df46b1de7e4560dc2a8Test
https://doi.org/10.1007/s13233-017-5159-9Test

المؤلفون: Han-Ik Joh, Doh C. Lee, Cheol-Ho Lee, Il-Doo Kim, Seokwon Lee, Jun Young Cheong, Kangha Lee

المصدر: Korean Journal of Chemical Engineering. 34:3214-3219

مصطلحات موضوعية: Photocurrent, business.industry, Chemistry, General Chemical Engineering, Inorganic chemistry, Doping, Heterojunction, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, Photocathode, 0104 chemical sciences, Ion, Depletion region, Optoelectronics, Water splitting, 0210 nano-technology, business

الوصف: We report photoelectrochemical hydrogen evolution reaction using a Cu2O-based photocathode with a layer doped with Zn ions. The doping results in the shift of the onset flat-band potential of the photocathode, likely a consequence of maximized band-bending in the Cu2O/Zn : Cu2O heterojunction. Systematic electrochemical analysis reveals that expansion of depletion region is responsible for the enhanced photoelectrochemical performance, e.g., the increase of photocurrent and reduced internal resistance.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d139d9695fbf34b1bcb2a3cf178f5dd2Test
https://doi.org/10.1007/s11814-017-0225-8Test

المؤلفون: Jin-Ki Kim, Isra Rana, Komal Naeem, Ho-Ik Choi, Namrah Khan, Maryam Afridi, Abir Abdullah Alamro, Fawad Ali Shah, Alam Zeb, Cheol Ho Lee, Chang-Wan Lim, Izhar Ullah, Sadia Sarwar, Fakhar ud Din, Sana Rubab

المصدر: International Journal of Pharmaceutics. 603:120670

مصطلحات موضوعية: Lipopolysaccharides, Elevated plus maze, Curcumin, Lipopolysaccharide, Pharmaceutical Science, 02 engineering and technology, Anxiety, Pharmacology, 030226 pharmacology & pharmacy, Neuroprotection, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Animals, Particle Size, Drug Carriers, Depression, Poloxamer, 021001 nanoscience & nanotechnology, Antidepressive Agents, Nanostructures, Rats, Oleic acid, chemistry, Antidepressant, 0210 nano-technology

الوصف: The present study aims to develop curcumin-loaded nanostructured lipid carriers (CUR-NLCs) and investigate their neuroprotective effects in lipopolysaccharide (LPS)-induced depression and anxiety model. Nanotemplate engineering technique was used to prepare CUR-NLCs with Compritol 888 ATO and oleic acid as solid and liquid lipid, respectively. Poloxamer 188, Tween 80 and Span 80 were used as stabilizing agents for solid–liquid lipid core. The physicochemical parameters of CUR-NLCs were determined followed by in vitro drug release and in vivo neuroprotective activity in rats. The optimized CUR-NLCs demonstrated nanometric particle size of 147.8 nm, surface charge of –32.8 mV and incorporation efficiency of 91.0%. CUR-NLCs showed initial rapid followed by a sustained drug release reaching up to 73% after 24 h. CUR-NLCs significantly elevated struggling time and decreased immobility time in forced swim and tail suspension tests. A substantial increase in time spent and number of entries into the light and open compartments was observed in light–dark box and elevated plus maze models. CUR-NLCs improved the tissue architecture and suppressed the expression of p-NF-κB, TNF-α and COX-2 in brain tissues from histological and immunohistochemical analysis. CUR-NLCs improved the neuroprotective effect of curcumin and can be used as a potential therapeutics for depression and anxiety.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44df10f1eb56de28ec736144b7c119d6Test
https://doi.org/10.1016/j.ijpharm.2021.120670Test

المؤلفون: Sang Youp Hwang, Han-Ik Joh, Hae Ri Lee, Cheol-Ho Lee, Sungho Lee, Su-Young Son

المصدر: Chemical Engineering Science. 231:116301

مصطلحات موضوعية: Materials science, Graphene, Applied Mathematics, General Chemical Engineering, chemistry.chemical_element, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, Capacitance, Redox, Environmentally friendly, Oxygen, Industrial and Manufacturing Engineering, law.invention, 020401 chemical engineering, Chemical engineering, chemistry, law, Electrical resistivity and conductivity, 0204 chemical engineering, 0210 nano-technology, Porosity

الوصف: In this study, reduced graphene oxides (rGOs) with a porous structure were synthesized through a facile sequential low-temperature treatment at 150 and 250 °C in air and nitrogen atmosphere, respectively, without toxic chemicals. For the first treatment under oxygen-rich conditions, competitive oxidation and reduction reactions between various kinds of oxygen functional groups were observed, leading to the formation of preferential pore-forming groups such as carboxyl. Weakly bound groups on the GO surface (such as hydroxyl and carboxyl groups) were removed in the second step, leading to the formation of pores and improving electrical conductivity. The rGO suitable for use as an electrode material had a surface area of 636.6 m2/g and a capacitance of 191.3 F/g. Therefore, we believe that this mild treatment could be a potentially cost-effective, efficient, and environmentally friendly strategy to synthesize electrode materials.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d2450211794fd81c9bdf4b7f466c236fTest
https://doi.org/10.1016/j.ces.2020.116301Test

المؤلفون: Seok-In Na, Jun-Seok Yeo, Han-Ik Joh, Jae-Hun Yu, Cheol-Ho Lee

المصدر: Nanoscale. 9:17167-17173

مصطلحات موضوعية: Materials science, Graphene, Graphene derivatives, Composite number, Energy conversion efficiency, Oxide, chemistry.chemical_element, Nanotechnology, 02 engineering and technology, Penetration (firestop), 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Oxygen, 0104 chemical sciences, law.invention, chemistry.chemical_compound, chemistry, PEDOT:PSS, Chemical engineering, law, General Materials Science, 0210 nano-technology

الوصف: We demonstrate that a bi-interlayer consisting of water-free poly(3,4-ethylenedioxythiophene) (PEDOT) and fluorinated reduced graphene oxide (FrGO) noticeably enhances the efficiency and the stability of the normal-structure perovskite solar cells (PeSCs). With simple and low temperature solution-processing, the PeSC employing the PEDOT + FrGO interlayer exhibits a significantly improved power conversion efficiency (PCE) of 14.9%. Comprehensive investigations indicate that the enhanced PCE is mostly attributed to the retarded recombination in the devices. The minimized recombination phenomena are related to the interfacial dipoles at the PEDOT/FrGO interface, which facilitates the electron-blocking and the higher built-in potential in the devices. Furthermore, the PEDOT + FrGO device shows a better stability by maintaining 70% of the initial PCE over the 30 days exposure to ambient conditions. This is because the more hydrophobic graphitic sheets of the FrGO on the PEDOT further protect the perovskite films from oxygen/water penetration. Consequently, the introduction of composite interfacial layers including graphene derivatives can be an effective and versatile strategy for high-performing, stable, and cost-effective PeSCs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fce25e4edb0ba7f3dea53ae226e1bbTest
https://doi.org/10.1039/c7nr03963hTest