المؤلفون: Yang Tang, Jian-Neng Yao, Zheng-Hui Li, Ji-Kai Liu, He-Ping Chen, Tao Feng, Zhen-Zhu Zhao

المصدر: Journal of Natural Products. 81:2163-2168

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, Irpex lacteus, Pharmaceutical Science, Fungus, Nitric Oxide, 010402 general chemistry, Cleavage (embryo), Ring (chemistry), 01 natural sciences, Lanostane, Analytical Chemistry, Mice, chemistry.chemical_compound, Ascomycota, Drug Discovery, Animals, RAW 264.7 Cells, Pharmacology, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Nuclear magnetic resonance spectroscopy, biology.organism_classification, Triterpenes, 0104 chemical sciences, Complementary and alternative medicine, chemistry, Molecular Medicine, Polyporales

الوصف: Five new triterpenoids, irpeksins A-E (1-5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well as absolute configurations of the new compounds were established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1-4 are featured by a scaffold of 1,10- seco- and ring B aromatic eburicane (24-methyllanostane), and compound 5 is characterized by a scaffold of 1,10-9,11- diseco- and ring B aromatic eburicane, which represents unprecedented cleavage patterns in the lanostane family. Compounds 1-5 showed significant inhibitory activity against NO production in LPS-activated RAW 264.7 macrophage cells with IC50 values varying from 2.2 to 19.6 μM.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32031a6ca6e9f480eb5b01ac69da5b5eTest
https://doi.org/10.1021/acs.jnatprod.7b00845Test

المؤلفون: Tao Feng, Zheng-Hui Li, Ji-Kai Liu, Marc Stadler, Ying Huang, Shuai-Bing Zhang, He-Ping Chen, Xiao-Qing Gan

المصدر: Phytochemistry. 152:105-112

مصطلحات موضوعية: Lipopolysaccharides, Stereochemistry, Antineoplastic Agents, Plant Science, Horticulture, Nitric Oxide, 010402 general chemistry, 01 natural sciences, Biochemistry, Lanostane, Tricholomataceae, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Triterpenoid, Cell Line, Tumor, Animals, Humans, Cytotoxic T cell, Fruiting Bodies, Fungal, No production, Molecular Biology, IC50, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Macrophages, Tricholoma, General Medicine, Tricholoma pardinum, biology.organism_classification, Triterpenes, 0104 chemical sciences, RAW 264.7 Cells, Drug Screening Assays, Antitumor, Human cancer

الوصف: Eight undescribed lanostane triterpenoids, pardinols A‒H, along with one previously reported lanostane triterpenoid, namely saponaceol B, were isolated from the fruiting bodies of Tricholoma pardinum. Their structures and stereoconfigurations were established via combination of extensive spectroscopic analyses, alkaline methanolysis method and TDDFT/ECD calculations. Pardinols B and E-H exhibited certain inhibition activities of nitric oxide (NO) production with IC50 value ranging from 5.3 to 14.7 μM, as well as cytotoxicities against human cancer cell-lines.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa453980ad8c8f0b00bbccf807bced07Test
https://doi.org/10.1016/j.phytochem.2018.05.002Test

المؤلفون: Bin Wu, He-Ping Chen, Jianping Zuo, Zheng-Hui Li, Ji-Kai Liu, Shuai-Bing Zhang, Ying Huang, Shanyong Li, Zhen-Zhu Zhao, Tao Feng, Xian Wang, Shijun He

المصدر: The Journal of Organic Chemistry. 83:10158-10165

مصطلحات موضوعية: Lipopolysaccharides, Stereochemistry, Lymphocyte, Stereoisomerism, 010402 general chemistry, 01 natural sciences, Mice, Heterocyclic Compounds, medicine, Albatrellus confluens, Ic50 values, Animals, Cell Proliferation, B-Lymphocytes, Mice, Inbred BALB C, Mushroom, biology, 010405 organic chemistry, Chemistry, Cell growth, Basidiomycota, Organic Chemistry, Total synthesis, biology.organism_classification, 0104 chemical sciences, medicine.anatomical_structure, Female

الوصف: Eight hetereocyclic compounds conflamides B–I with an unprecedented skeleton and their precursor conflamide A were isolated from the mushroom Albatrellus confluens. Their structures and absolute configurations were determined by use of NMR studies, total synthesis, and calculated ECD spectra. Conflamides D and E were found to exhibit potent inhibition against LPS-induced B lymphocyte cell proliferation with IC50 values 1.48 and 5.71 μM, respectively.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667d1d5fe2b6f4c528cc641eb45ef196Test
https://doi.org/10.1021/acs.joc.8b01420Test

المؤلفون: Jing Li, Tao Feng, Zheng-Hui Li, Gui-Guang Cheng, Hong-Lian Ai, Ji-Kai Liu, Wen-Xuan Wang, Juan He

المصدر: Organicbiomolecular chemistry. 17(34)

مصطلحات موضوعية: Male, Lipopolysaccharide, Lymphocyte, T-Lymphocytes, Xylaria, 010402 general chemistry, 01 natural sciences, Biochemistry, Microbiology, chemistry.chemical_compound, medicine, Animals, Physical and Theoretical Chemistry, Cytotoxicity, IC50, Cell Proliferation, B-Lymphocytes, Mice, Inbred BALB C, biology, Molecular Structure, Xylariales, 010405 organic chemistry, Cell growth, Organic Chemistry, T lymphocyte, biology.organism_classification, Cytochalasins, 0104 chemical sciences, medicine.anatomical_structure, chemistry, Concanavalin A, biology.protein, Immunosuppressive Agents

الوصف: Eleven new cytochalasins, curtachalasins F-P (1-11), were isolated from the rice fermentation of endophytic fungus Xylaria cf. curta. Their structures were identified by extensive spectroscopic methods, X-ray diffraction, and quantum chemistry calculations. Curtachalasin P possesses a unique 5/6/6/7 fused ring system. In the bioactivity screening for curtachalasins F-P, A-C, and E (1-15), compounds 1, 3-6, 8-13, and 15 did not show obvious cytotoxicity against primary mouse splenocytes. Furthermore, the immunosuppressive assay against concanavalin A (ConA) induced T lymphocyte cell proliferation and lipopolysaccharide (LPS) induced B lymphocyte cell proliferation showed that compound 1 results in significant selective inhibition on B-cell proliferation (IC50 value of 2.42 μM) and compound 10 has selective inhibition on T-cell proliferation (IC50 value of 12.15 μM). These interesting immunosuppressive properties of this class of compounds provide new clues to fulfill the urgent demand for new immunosuppressive drugs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98dc66cfef647819025b0f5abdb230dTest
https://pubmed.ncbi.nlm.nih.gov/31408074Test

المؤلفون: Wen-Zhe Xie, Tao Feng, Hui-Xiang Yang, Zheng-Hui Li, Ji-Kai Liu

المصدر: Fitoterapia. 148:104777

مصطلحات موضوعية: China, Circular dichroism, Stereochemistry, T-Lymphocytes, T cell, Phytochemicals, Rubiaceae, 01 natural sciences, B-cell proliferation, Indole Alkaloids, Drug Discovery, medicine, Animals, IC50, Cells, Cultured, Cell Proliferation, Pharmacology, Indole test, B-Lymphocytes, Mice, Inbred BALB C, Molecular Structure, biology, 010405 organic chemistry, Chemistry, General Medicine, biology.organism_classification, Ophiorrhiza, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Female, Immunosuppressive Agents, Spleen

الوصف: Three new indole alkaloids, ophiorrhines C–D (1–3), together with one known analogue, have been isolated from the plant of Ophiorrhiza cantoniensis Hace. The structures of the new alkaloids with the absolute configurations were elucidated by means of spectroscopic methods, electronic circular dichroism (ECD) and calculated nuclear magnetic resonance (NMR) with DP4+ analysis. Compounds 1 and 2 exhibited certain activity to Con-A induced T cell proliferation, and 1 exhibited good inhibition on LPS-induced B cell proliferation with an IC50 value of 8.7 μM.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae68c6ce3a91deb0206aead97b9d0791Test
https://doi.org/10.1016/j.fitote.2020.104777Test

المؤلفون: Ji-Kai Liu, Xue-Mei Li, Zhong-Yu Zhou, Zheng-Hui Li, Jin-Long Cai, Tao Feng

المصدر: Journal of Agricultural and Food Chemistry. 64:1945-1949

مصطلحات موضوعية: China, Antineoplastic Agents, Biology, Nitric Oxide, 01 natural sciences, Lanostane, Mice, chemistry.chemical_compound, Triterpenoid, Cell Line, Tumor, Ergosterol, Animals, Humans, Fruiting Bodies, Fungal, Medicine, Chinese Traditional, Mushroom, Phellinus rhabarbarinus, Molecular Structure, Traditional medicine, 010405 organic chemistry, Basidiomycota, Macrophages, General Chemistry, Triterpenes, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, RAW 264.7 Cells, chemistry, Chemical constituents, General Agricultural and Biological Sciences, Human cancer

الوصف: Phellinus rhabarbarinus soaked in wine has folk usages by local residents of Ailao mountain of Yunnan province, China, which were to daub the wound to prevent infection and to drink to enhance immunity and treat other diseases such as cough, gastritis, and cancer. Systemic investigation on the chemical constituents of fruiting bodies of P. rhabarbarinus resulted in the isolation of 11 lanostane triterpenoids (1-10) including three new ones, namely, phellibarins A-C (1-3), together with five ergosterols (11-15). This is the first time reporting secondary metabolites of P. rhabarbarinus. Compounds 2, 3, 7, and 8 showed inhibitory activities against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages, whereas compounds 2-4, 6, 7, and 10 exhibited cytotoxicities against human cancer cell lines. The results of this assessment suggested that the lanostane triterpenoids in fruiting bodies of P. rhabarbarinus played key roles in its folk usages.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba5306426ffd58f0ace54c0bf984714Test
https://doi.org/10.1021/acs.jafc.6b00176Test

المؤلفون: Li-Tang Sun, Hui-Xiang Yang, Zheng-Hui Li, Hong-Lian Ai, Ji-Kai Liu, Guo-Kai Wang, Tao Feng, Yao Chen

المصدر: Fitoterapia. 141:104483

مصطلحات موضوعية: Lipopolysaccharides, Boeremia exigua, Circular dichroism, Stereochemistry, Anti-Inflammatory Agents, Depsides, 01 natural sciences, Mice, Ascomycota, Drug Discovery, Endophytes, Ic50 values, Animals, Solanum tuberosum, Inflammation, Pharmacology, Molecular Structure, 010405 organic chemistry, Chemistry, General Medicine, Endophytic fungus, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, RAW 264.7 Cells, Cancer cell lines, Human breast

الوصف: Three depsidones boremexins A–C (1–3), two diaryl ethers boremexins D (4) and E (5), together with four known compounds were obtained from cultures of potato endophytic fungus Boeremia exigua. Their structures with absolute configurations were established by extensive spectroscopic methods and electronic circular dichroism (ECD) calculations. Compounds 1–4, 6, and 9 displayed anti-inflammatory properties on nitric oxide production in LPS-induced RAW264.7 macrophages with an IC50 range of 19.4–34.4 μM. Compounds 2 and 5 exhibited cytotoxicities to human breast cancer cell line (MCF–7) with IC50 values of 33.1 and 4.0 μM, respectively.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23a6fa3fd30d73b9b31c267b0003517Test
https://doi.org/10.1016/j.fitote.2020.104483Test

المؤلفون: Zheng-Hui Li, Ji-Kai Liu, Tao Feng, Xia Yin

المصدر: Chemistry (Weinheim an der Bergstrasse, Germany). 22(16)

مصطلحات موضوعية: 0301 basic medicine, Male, Mushroom, biology, 010405 organic chemistry, Tricholoma terreum, Chemistry, Organic Chemistry, Tricholoma, Environmental ethics, General Chemistry, biology.organism_classification, 01 natural sciences, Catalysis, 0104 chemical sciences, Toxicology, 03 medical and health sciences, 030104 developmental biology, Animals, Female, Dose conversion

الوصف: Recently, Dr. Paolo Davoli and his colleagues stated that the conclusions drawn by us were misleading from a mycotoxicological perspective, as they cast doubts on the edibility of a mushroom species (Tricholoma terreum) that has been always recognized as safe. Unfortunately, they made a mistake, and seriously misinterpreted our data, which resulted in scepticism of our research. Saponaceolides B and M were tested for their stabilities heating directly on and boiling in water. It is undoubted that both saponaceolides B and M are capable of withstanding prolonged heating during cooking.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3458f9391db8590770eb360700d47efbTest
https://pubmed.ncbi.nlm.nih.gov/26969909Test