Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment
| العنوان: | Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment |
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| المؤلفون: | Jingjing Wang, Zuan Ma, Maciej S. Lesniak, Liqun Huang, Peng Ning, Jiaojiao Wu, Zhongmin Liu, Yajing Shen, Chang Xu, Yu Cheng, Mengwei Chen, Yu Han, Gustavo R. Plaza |
| المصدر: | Small. 16:1905424 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cell, 02 engineering and technology, Mitochondrion, 010402 general chemistry, 01 natural sciences, Biomaterials, Magnetics, In vivo, Cell Line, Tumor, Neoplasms, medicine, Humans, Nanotechnology, Cell Lineage, General Materials Science, Mechanical Phenomena, Chemistry, Cancer, General Chemistry, Adhesion, 021001 nanoscience & nanotechnology, medicine.disease, In vitro, Mitochondria, 0104 chemical sciences, medicine.anatomical_structure, Apoptosis, Cancer cell, Biophysics, 0210 nano-technology, Biotechnology |
| الوصف: | In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep-seated tumors in a spatiotemporal fashion. |
| تدمد: | 1613-6829 1613-6810 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e10932c598aa46089168d7e1f5dbe1Test https://doi.org/10.1002/smll.201905424Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e3e10932c598aa46089168d7e1f5dbe1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16136829 16136810 |
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