Application of Thiol-Modified Dual-Pore Silica Beads as a Practical Scavenger of Leached Palladium Catalyst in C–C Coupling Reactions
| العنوان: | Application of Thiol-Modified Dual-Pore Silica Beads as a Practical Scavenger of Leached Palladium Catalyst in C–C Coupling Reactions |
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| المؤلفون: | Hironao Sajiki, Yasunari Monguchi, Tomohiro Ichikawa, Hayato Masuda, Yoshinari Sawama, Kanji Meguro, Riichi Miyamoto, Tomohiro Matsuo, Hongzhi Bai, Aya Ogawa, Yutaka Kobayashi, Tsuyoshi Yamada |
| المصدر: | Organic Process Research & Development. 23:462-469 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | inorganic chemicals, 010405 organic chemistry, Organic Chemistry, Ethyl acetate, Sonogashira coupling, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Coupling reaction, Scavenger (chemistry), 0104 chemical sciences, Catalysis, chemistry.chemical_compound, chemistry, Palladium on carbon, Methanol, Physical and Theoretical Chemistry, Nuclear chemistry, Palladium |
| الوصف: | A practical and efficient method for scavenging palladium leached into the reaction mixture using thiol-modified dual-pore silica beads has been developed. Reducing the level of metal contamination, especially palladium, in pharmaceutical and bioactive compounds and fine chemicals to below the regulatory value is quite important for the quality assurance of industrial products. We have evaluated the performance of dual-pore silica beads as a palladium scavenger by investigating their ability to eliminate the divalent palladium ions in dilute palladium(II) acetate in methanol (5 and 50 ppm) and ethyl acetate (5 ppm) solutions. The ability of the dual-pore silica beads to eliminate the palladium species leached from a 10% palladium on carbon (Pd/C) catalyst during the ligand- and copper-free 10% Pd/C-catalyzed Sonogashira-type coupling reaction was also investigated. The thiol-modified dual-pore silica beads exhibit a more rapid and effective elimination ability toward leached palladium species in the react... |
| تدمد: | 1520-586X 1083-6160 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::63f60e6579f41615afe57ae78b584059Test https://doi.org/10.1021/acs.oprd.8b00291Test |
| رقم الانضمام: | edsair.doi...........63f60e6579f41615afe57ae78b584059 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1520586X 10836160 |
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