يعرض 1 - 2 نتائج من 2 نتيجة بحث عن '"Katsumi Higaki"', وقت الاستعلام: 1.23s تنقيح النتائج
  1. 1
    Efficient stereoselective synthesis of 2-acetamido-1,2- dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme

    المؤلفون: Xavier Verdaguer, José M. García Fernández, Katsumi Higaki, Eiji Nanba, Alex de la Fuente, Antoni Riera, Carmen Ortiz Mellet, Rocío Rísquez-Cuadro

    المساهمون: Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Economía y Competitividad (MINECO). España, Junta de Andalucía, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), European Commission. Fondo Social Europeo (FSO), Universidad de Sevilla

    المصدر: Digital.CSIC. Repositorio Institucional del CSIC
    instname
    idUS. Depósito de Investigación de la Universidad de Sevilla

    مصطلحات موضوعية: Models, Molecular, 1-Deoxynojirimycin, Stereochemistry, Hexosaminidase inhibitors, Mutant, Molecular Conformation, Iminosugar, Chemistry Techniques, Synthetic, Tay-Sachs disease, 010402 general chemistry, 01 natural sciences, Drug Discovery, Humans, Hexosaminidase, Glycoside hydrolase, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, Stereoselective synthesis, Stereoisomerism, General Medicine, Pharmacological chaperones, Imino Sugars, 0104 chemical sciences, Hexosaminidases, Kinetics, Enzyme, chemistry, Biochemistry, sp2-iminosugars, Stereoselectivity

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5cdb2c357f4536852ffe09288c201aTest
    http://hdl.handle.net/10261/137497Test


    أضف إلى المفضلة
  2. 2
    Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts

    المؤلفون: José M. García Fernández, Katsumi Higaki, Alda Lisa Concia, Pere Clapés, M. Isabel García-Moreno, Teresa Mena-Barragán, Carmen Ortiz Mellet, Eiji Nanba

    المصدر: European journal of medicinal chemistry. 121

    مصطلحات موضوعية: Glycoside Hydrolases, Stereochemistry, Iminosugar, 010402 general chemistry, 01 natural sciences, Pyrrolidine, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Moiety, Humans, Enzyme Inhibitors, Pharmacology, Gaucher Disease, biology, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, General Medicine, Fibroblasts, 0104 chemical sciences, Imino Sugars, Pharmacological chaperone, chemistry, Biochemistry, Chaperone (protein), biology.protein, Triol, medicine.drug, Imino Pyranoses

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ff26fc321962d3a0dce4a4e17f3d25Test
    https://pubmed.ncbi.nlm.nih.gov/26361824Test


    أضف إلى المفضلة
أدوات البحث: أحصل على تغذية RSS — أرسل هذا البحث بالبريد الإلكتروني — حفظ البحث