On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries
| العنوان: | On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries |
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| المؤلفون: | Weiwei Lu, Xin Wen, Xiaojie Lu, Jiaxiang Liu, Zhiqiang Duan |
| المصدر: | Organic Letters. 22:5721-5725 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Molecular Structure, Nitromethane, 010405 organic chemistry, Tetrahydroisoquinoline, Organic Chemistry, DNA, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, Coupling reaction, Chemical space, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Nucleophile, Alkynes, Tetrahydroisoquinolines, Molecule, Physical and Theoretical Chemistry, Gene Library |
| الوصف: | To expand the chemical space of DNA-encoded library (DEL) technology, we have developed the DNA-compatible cross-dehydrogenative coupling reaction between tetrahydroisoquinolines (THIQs) and a series of nucleophiles such as nitromethane, terminal alkynes, and so on. Both photo- and metal-promoted conditions have been successfully established for this C-1 derivation of THIQs, as exemplified by the addition of nitromethane. All of these new DNA-compatible transformations have paved the way for the divergent oriented synthesis of THIQ-focused DELs. |
| تدمد: | 1523-7052 1523-7060 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd424a18229fa7ad21512fedc8f4318aTest https://doi.org/10.1021/acs.orglett.0c01565Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cd424a18229fa7ad21512fedc8f4318a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
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