Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum
| العنوان: | Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum |
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| المؤلفون: | Juan He, Ji-Kai Liu, Zheng-Hui Li, Yue-Ling Peng, Tao Feng, Chen Shi |
| المصدر: | Natural Products and Bioprospecting |
| بيانات النشر: | Springer Singapore, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Wild mushroom, Stereochemistry, Cytotoxicity, Plant Science, Toxicology, 01 natural sciences, Biochemistry, Chemical conversion, Analytical Chemistry, HeLa, 03 medical and health sciences, Triterpenoid, Bioorganic chemistry, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Tricholoma, Tricholoma pardinum, biology.organism_classification, 0104 chemical sciences, Cell culture, Original Article, Tricholoma triterpenoids, Food Science |
| الوصف: | Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC50 values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly. Graphical Abstract |
| اللغة: | English |
| تدمد: | 2192-2209 2192-2195 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904344f1faeb6f11d9f2049e4284175cTest http://europepmc.org/articles/PMC7981340Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....904344f1faeb6f11d9f2049e4284175c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21922209 21922195 |
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