A perspective on the diagnostics, prognostics, and therapeutics of microRNAs of triple-negative breast cancer
| العنوان: | A perspective on the diagnostics, prognostics, and therapeutics of microRNAs of triple-negative breast cancer |
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| المؤلفون: | Anil Kumar Badana, Seema Kumari, Rama Rao Malla, Prasuja Rokkam, Murali Mohan Gavara, Shailender Gugalavath, Deepak Kakara Gift Kumar |
| المصدر: | Biophysical Reviews. 11:227-234 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Angiogenesis, medicine.medical_treatment, Biophysics, Review, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Targeted therapy, 03 medical and health sciences, Breast cancer, Structural Biology, Internal medicine, microRNA, medicine, Molecular Biology, Triple-negative breast cancer, 030304 developmental biology, 0303 health sciences, business.industry, medicine.disease, 0104 chemical sciences, Prognostics, Cancer biomarkers, business, Carcinogenesis |
| الوصف: | Triple-negative breast cancer (TNBC) is the most aggressive and prevalent subtype of breast cancer in women worldwide. Currently, chemotherapy remains the main modality for the treatment at an early stage, as there is no approved targeted therapy for early TNBC. In this review, we investigate the use of microRNAs (miRNAs), which play a key role in the post-transcriptional regulation of genes involved in the key biological processes, namely proliferation, differentiation, angiogenesis, migration, apoptosis, and carcinogenesis. Here, we emphasize the importance of the recent advances related to miRNAs, involving diagnosis, prognosis, and treatment of TNBC. We focus on the development, optimization, and stabilization of miRNA-based drugs; improvement of miRNA delivery; and control of the off-target effects of miRNA therapeutics. We speculate as to which features may present themselves as promising approaches in the treatment of TNBC. |
| تدمد: | 1867-2469 1867-2450 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02347ec63825c17a7f8fdd35c2d511b2Test https://doi.org/10.1007/s12551-019-00503-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....02347ec63825c17a7f8fdd35c2d511b2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18672469 18672450 |
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