Vibralactone Biogenesis-Associated Analogues from Submerged Cultures of the Fungus Boreostereum vibrans
| العنوان: | Vibralactone Biogenesis-Associated Analogues from Submerged Cultures of the Fungus Boreostereum vibrans |
|---|---|
| المؤلفون: | Zhen-Zhu Zhao, Ji-Kai Liu, Meng-Yuan Jiang, Zheng-Hui Li, He-Ping Chen, Tao Feng |
| المصدر: | Natural Products and Bioprospecting Natural Products and Bioprospecting, Vol 8, Iss 1, Pp 37-45 (2017) |
| بيانات النشر: | Springer Singapore, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Stereochemistry, Structural diversity, Plant Science, Fungus, 010402 general chemistry, Toxicology, 01 natural sciences, Biochemistry, Analytical Chemistry, Vibralactone, chemistry.chemical_compound, Biosynthesis, lcsh:Botany, Bioorganic chemistry, Pharmacology, Boreostereum vibrans, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Absolute configuration, Snatzke’s method, biology.organism_classification, 0104 chemical sciences, lcsh:QK1-989, Structure revision, Basidiomycete, Original Article, Biogenesis, Food Science |
| الوصف: | A scale-up fermentation of the fungus Boreostereum vibrans facilitated the isolation of six new vibralactone biogenesis-associated analogues, namely vibralactamide A (1), vibralactone T (2), 13-O-lactyl vibralactone (3), 10-O-acetyl vibralactone G (4), (11R,12R)- and (11S,12R)-vibradiol (5, 6). Their structures were established via extensive spectroscopic analyses, specific optical rotation comparison, and Snatzke’s method. The biosynthetic pathway for vibralactamide A was postulated. The absolute configuration of vibralactone B was revised by single crystal X-ray diffraction analysis. This work puts the divergent vibralactone biosynthesis pathway one step further and expands the structural diversity of vibralactone-associated compounds. Graphical Abstract Electronic supplementary material The online version of this article (10.1007/s13659-017-0147-5) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 2192-2209 2192-2195 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b04eff81601e7302293e63e2fc11e5Test http://europepmc.org/articles/PMC5803143Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....33b04eff81601e7302293e63e2fc11e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21922209 21922195 |
|---|