代谢危险因素是导致心脑血管病的重要原因。目前代谢性心血管病已有明确的概念和综合管理体系，而在我国发病率高、异质性强的脑血管病领域，尚未形成统一的代谢性脑血管病的定义和概念。本文综述脑血管病的代谢危险因素，提出代谢性脑血管病的概念和分类，阐述基于多组学技术的多学科、多器官水平的研究方法，介绍近年来涌现的具有心血管获益的代谢药物的特点及未来面临的挑战和研究方向，为代谢性脑血管病的综合管理提供理论依据。 Abstract: Metabolic risk factors are important causes of cardiovascular and cerebrovascular diseases. There is already a definite concept and comprehensive management system for cardio-metabolic disease. While the incidence rate of stroke is higher and exhibit greater heterogeneity in China, and lacks a concept of cerebro-metabolic disease currently. Therefore, we reviewed the metabolic risk factors of stroke, proposed the concept and classification of cerebro-metabolic disease, elucidated the interdisciplinary and multi-organ level research methods based on multi-omics technology, introduced the characteristics of recently emerged metabolic drugs with cardiovascular benefits and the challenges and future directions. We aimed to provide a theoretical basis for the comprehensive management of cerebro-metabolic disease.
