دورية أكاديمية
Endometrial hyperplasia features in conditions of organic solvents exposure ; Особенности гиперплазии эндометрия в условиях воздействия органических растворителей
| العنوان: | Endometrial hyperplasia features in conditions of organic solvents exposure ; Особенности гиперплазии эндометрия в условиях воздействия органических растворителей |
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| المؤلفون: | I. O. Marinkin, L. A. Shpagina, E. S. Lisova, I. S. Shpagin, O. S. Kotova, G. V. Kuznetsova, E. M. Loktin, S. A. Karmanovskaya, И. О. Маринкин, Л. А. Шпагина, Е. С. Лисова, И. С. Шпагин, О. С. Котова, Г. В. Кузнецова, Е. М. Локтин, С. А. Кармановская |
| المصدر: | Medical Herald of the South of Russia; Том 13, № 4 (2022); 28-38 ; Медицинский вестник Юга России; Том 13, № 4 (2022); 28-38 ; 2618-7876 ; 2219-8075 ; 10.21886/2219-8075-2022-13-4 |
| بيانات النشر: | The Rostov State Medical University |
| سنة النشر: | 2023 |
| المجموعة: | Medical Herald of the South of Russia / Медицинский вестник Юга России |
| مصطلحات موضوعية: | гиперплазия эндометрия, organic solvents, endometrial hyperplasia, органические растворители |
| الوصف: | Objective: to establish clinical and molecular features of endometrial hyperplasia in conditions of organic solvents exposure in patients with obesity. Materials and methods: postmenopausal women with endometrial hyperplasia (morphological criteria) were included to observational cross-sectional study. The main group included 140 subjects with occupational organic solvents exposure, aged 57,5 (46;64) years, of whom 70 had obesity and 70 had normal weight. Comparison group — 140 women without of occupational health risks, aged 56,5 (46;65) years, 68 with and 72 without obesity. Investigated workers were painters in machine building industry with length of service above 10 years, in post-contact period lasted for 1-5 years were 29 (20.7%) of participants. Organic solvents concentrations at the workplace’s areas were 1.5-5.5 times above occupational exposure limits. Linear and logistic regression were used to explore relationships. Level of significance p<0.05. Results: workers exposed to organic solvents had maximal percent of atypical endometrial hyperplasia: 34.3% in obesity subjects and 18.6% in those without obesity, in the comparison group 10.3% in subjects with and 6.9% in those without obesity, p=0.004. Subgroup with toxicant exposure with obesity characterized by maximal expression of Ki-67 (55,9±2,51, 51,4±4,95, 41,5±3,29 and 30,1±2,18 scores respectively), higher rate of uterine bleeding, M-echo thickness, blood interleukin 1β concentration. Atypical endometrial hyperplasia was associated with length of service (OR 1.80), maximal short-term exposure concentration of toluene (OR 2.51), waist circumference (OR 1.68), Ki-67 (OR 2,01), estrogen receptors on epithelium (OR 1.92). Conclusions: organic solvents exposure in postmenopausal women with endometrial hyperplasia contributes to development of atypical hyperplasia, systemic inflammation, Ki-67 expression, higher grades in subjects with obesity. ; Цель: установить клинические и молекулярные особенности гиперплазии эндометрия (ГЭ) в условиях ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
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| DOI: | 10.21886/2219-8075-2022-13-4-28-38 |
| الإتاحة: | https://doi.org/10.21886/2219-8075-2022-13-4-28-38Test https://doi.org/10.21886/2219-8075-2022-13-4Test https://doi.org/10.1016/j.envres.2020.110694Test https://doi.org/10.3390/ijerph18105353Test https://doi.org/10.1016/j.ecoenv.2020.111520Test https://doi.org/10.21668/health.risk/2017.3.11Test https://doi.org/10.3892/ol.2020.12145Test https://doi.org/10.1002/cncr.32822Test https://doi.org/10.1111/aogs.13733Test https://doi.org/10.1016/j.ajog.2009.02.032Test |
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| رقم الانضمام: | edsbas.21E4A119 |
| قاعدة البيانات: | BASE |
| DOI: | 10.21886/2219-8075-2022-13-4-28-38 |
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